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Q86U44 | MTA70_HUMAN | N6-adenosine-methyltransferase catalytic subunit (METTL3)

3D structures mapped by conservation among orthologs

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // MT-A70 ]

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[ Domain: "CCCH zinc finger" // UNK_F_TYPE ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4854665 OBDepict CH 3 N H N O H O H HO H N H HO N N N H 2 N N H 3 C IC50 < 10.0 nM 502.54 CNc1ccc2ccc(OC[C@H]3O[C@@H](n4cc(-c5ccn(C)n5)c5c(N)ncnc54)[C@H](O)[C@@H]3O)cc2n1 Homo sapiens CHEMBL4827621 single protein format
CHEMBL4850503 OBDepict CH 3 N H N O H O H HO H N H HO N N H 2 N IC50 < 10.0 nM 504.59 CCNc1ccc2ccc(OC[C@H]3O[C@@H](n4cc(C5CCCC5)c5c(N)ncnc54)[C@H](O)[C@@H]3O)cc2n1 Homo sapiens CHEMBL4827621 single protein format
CHEMBL4872977 OBDepict CH 3 N H N O H O H HO H N H F N O N H 2 N H 3 C IC50 < 10.0 nM 504.52 CNc1ccc2ccc(OC[C@H]3O[C@@H](n4cc(-c5ccc(C)o5)c5c(N)ncnc54)[C@@H](F)[C@@H]3O)cc2n1 Homo sapiens CHEMBL4827621 single protein format
CHEMBL4856985 OBDepict CH 3 N O N NH 2 N N H O H F H H HO O N N IC50 < 10.0 nM 531.55 Cc1coc(-c2cn([C@@H]3O[C@H](COc4ccc5ccc(N6CCC6)nc5c4)[C@@H](O)[C@@H]3F)c3ncnc(N)c23)n1 Homo sapiens CHEMBL4827621 single protein format
CHEMBL4861007 OBDepict NH 2 N N N N N H O H F H H HO O N N IC50 < 10.0 nM 516.54 Nc1ncnc2c1c(-n1cccn1)cn2[C@@H]1O[C@H](COc2ccc3ccc(N4CCC4)nc3c2)[C@@H](O)[C@@H]1F Homo sapiens CHEMBL4827621 single protein format
CHEMBL4852677 OBDepict NH 2 N N N H O H O H F H H HO O N N IC50 < 10.0 nM 520.57 Nc1ncnc2c1c([C@@H]1CCCO1)cn2[C@@H]1O[C@H](COc2ccc3ccc(N4CCC4)nc3c2)[C@@H](O)[C@@H]1F Homo sapiens CHEMBL4827621 single protein format