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Q86W56 | PARG_HUMAN | Poly(ADP-ribose) glycohydrolase (PARG)

3D structures mapped by conservation among orthologs

[ Domain: "Poly(ADP-ribose) glycohydrolase helical domain" // PARG_cat_N ]

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[ Domain: "Macro domain-like" // PARG_cat_C ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4459166 OBDepict H 3 C N N N O O N S N HN O O D D D N H 3 C IC50 = 70.0 nM 486.57 [2H]C([2H])([2H])C1(NS(=O)(=O)c2ccc3c(c2)c(=O)n(Cc2cnn(C)c2)c(=O)n3Cc2ccn(C)n2)CC1 Homo sapiens CHEMBL4333012 cell-based format
CHEMBL4438105 OBDepict H 3 C N O N O S HN O O F N N H 3 C IC50 = 80.0 nM 435.48 CCn1c(=O)n(Cc2cnn(C)c2)c(=O)c2cc(S(=O)(=O)NC3(CF)CC3)ccc21 Homo sapiens CHEMBL4333012 cell-based format
CHEMBL4282082 OBDepict H 3 C N O N O S HN O O H 3 C N N H 3 C IC50 = 80.0 nM 417.49 CCn1c(=O)n(Cc2cnn(C)c2)c(=O)c2cc(S(=O)(=O)NC3(C)CC3)ccc21 Homo sapiens CHEMBL4333012 cell-based format
CHEMBL4518815 OBDepict CH 3 N N N O O N S N HN O O CH 3 N H 3 C IC50 = 90.0 nM 483.55 Cn1cc(Cn2c(=O)c3cc(S(=O)(=O)NC4(C)CC4)ccc3n(Cc3ccn(C)n3)c2=O)cn1 Homo sapiens CHEMBL4333012 cell-based format
CHEMBL1230692 OBDepict H 2 N N N N N H O H HO H H OH O P O O OH P O O OH H N H H OH H HO IC50 = 120.0 nM 542.34 Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL1814966 single protein format
CHEMBL4459798 OBDepict F N H S O O N O N O N N N N H 3 C CH 3 IC50 = 170.0 nM 501.54 Cn1cc(Cn2c(=O)c3cc(S(=O)(=O)NC4(CF)CC4)ccc3n(Cc3ccn(C)n3)c2=O)cn1 Homo sapiens CHEMBL4333012 cell-based format
CHEMBL4452307 OBDepict F HN S O O N O N H 3 C O N N H 3 C IC50 = 290.0 nM 421.45 Cn1cc(Cn2c(=O)c3cc(S(=O)(=O)NC4(CF)CC4)ccc3n(C)c2=O)cn1 Homo sapiens CHEMBL4333012 cell-based format
CHEMBL4456850 OBDepict CH 3 N N N O O N S N HN O O F F N H 3 C IC50 = 320.0 nM 519.53 Cn1cc(Cn2c(=O)c3cc(S(=O)(=O)NC4(C(F)F)CC4)ccc3n(Cc3ccn(C)n3)c2=O)cn1 Homo sapiens CHEMBL4333011 cell-based format
CHEMBL4283111 OBDepict H 3 C N N N O O N H 3 C S HN O O H 3 C IC50 = 330.0 nM 403.46 Cn1cc(Cn2c(=O)c3cc(S(=O)(=O)NC4(C)CC4)ccc3n(C)c2=O)cn1 Homo sapiens CHEMBL4333012 cell-based format