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Q8NEB9 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

3D structures mapped by conservation among orthologs

[ Domain: "ARM repeat" // PI3Ka ]

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[ Domain: "Protein kinase" // PI3_PI4_kinase ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -107400.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804466 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -15000.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804466 cell-based format
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -13200.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804466 cell-based format
CHEMBL3622372 OBDepict Cl N N N N H F F F N O H CH 3 O IC50 = 1.2 nM 443.86 C[C@@H]1COCCN1c1cc(=O)n2c(n1)N(Cc1cncc(Cl)c1)[C@H](C(F)(F)F)CC2 Homo sapiens CHEMBL3626567 single protein format
CHEMBL4517404 OBDepict O N N N N H O F F F OH H IC50 = 2.0 nM 424.42 O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2C[C@@H](O)c1ccccc1 Homo sapiens CHEMBL4308983 single protein format
CHEMBL1914726 OBDepict F S HN O O Cl N N N IC50 = 2.9 nM 490.95 O=S(=O)(Nc1cc(-c2ccc3nccc(-c4cccnc4)c3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL1919868 single protein format
CHEMBL4536755 OBDepict O N N N N H O F F F OH H IC50 = 3.0 nM 424.42 O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2C[C@H](O)c1ccccc1 Homo sapiens CHEMBL4308983 single protein format
CHEMBL4862803 OBDepict H N O N N H H H O Ki = 4.0 nM 351.45 O=c1cc(N2CCOCC2)cc(N2C[C@@H]3C[C@@H]3[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4857803 OBDepict H N O N N N H H H O Ki = 5.0 nM 352.44 O=c1cc(N2CCOCC2)nc(N2C[C@@H]3C[C@@H]3[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL1914743 OBDepict F S HN O O Cl N N N N O IC50 = 5.0 nM 499.96 O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL1919868 single protein format
CHEMBL1914727 OBDepict F S HN O O Cl N N N IC50 = 5.3 nM 490.95 O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL1919868 single protein format
CHEMBL4852400 OBDepict O N H N N N H O H H 3 C Ki = 6.0 nM 354.45 C[C@@H]1CCN(c2nc(N3CCOCC3)cc(=O)[nH]2)[C@H]1Cc1ccccc1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4470174 OBDepict CH 3 O H 3 C N N N H F F F N O O IC50 = 7.0 nM 390.41 CC(C)OCCN1c2nc(N3CCOCC3)cc(=O)n2CC[C@H]1C(F)(F)F Homo sapiens CHEMBL4308983 single protein format
CHEMBL4536855 OBDepict F F N N N H F F F N O O IC50 = 7.0 nM 416.35 O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2c1cc(F)cc(F)c1 Homo sapiens CHEMBL4308983 single protein format
CHEMBL4850755 OBDepict H N O N N N H O Ki = 8.0 nM 368.48 O=c1cc(N2CCOCC2)nc(N2CCCCC[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL1765602 OBDepict NH 2 N N N O F F F IC50 = 8.58 nM 432.41 Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 Homo sapiens CHEMBL1768756 single protein format
CHEMBL4873212 OBDepict O N H N N H O Ki = 9.0 nM 339.44 O=c1cc(N2CCOCC2)cc(N2CCC[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL1738719 OBDepict F S HN O O Cl N N N O IC50 = 11.0 nM 498.97 O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCOCC4)c3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL1919868 single protein format
CHEMBL4745255 OBDepict O O N S O O H 3 C H N O IC50 = 14.0 nM 520.65 C[C@H](CN1CCOCC1)Oc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)o3)c1S2 Homo sapiens CHEMBL4682233 single protein format
CHEMBL3781466 OBDepict CH 3 OH H 3 C NH N N N N N H N IC50 = 15.0 nM 391.48 CC(C)(O)CNc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4792737 OBDepict CH 3 O S O O N O Ki = 15.0 nM 407.49 COc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)o3)c1S2 Homo sapiens CHEMBL4823701 assay format
CHEMBL4878312 OBDepict OH N N N N H O Ki = 16.0 nM 340.43 Oc1cc(N2CCOCC2)nc(N2CCC[C@@H]2Cc2ccccc2)n1 Homo sapiens CHEMBL4823701 assay format
CHEMBL2140173 OBDepict O N H N H H 3 C O H H 3 C S O O N O IC50 = 17.0 nM 547.68 C[C@H]1CN(CC(=O)Nc2ccc3c(c2)Cc2cccc(-c4cc(=O)cc(N5CCOCC5)o4)c2S3)C[C@@H](C)O1 Homo sapiens CHEMBL4682233 single protein format
CHEMBL3781415 OBDepict NH 2 N N N N N H N IC50 = 18.0 nM 319.37 Nc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4447963 OBDepict NH 2 N H O N S H 3 C N N H Cl S O O H 3 C H 3 C CH 3 IC50 = 19.0 nM 494.04 Cc1nc(NC(=O)CN)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 Homo sapiens CHEMBL4308988 single protein format
CHEMBL4760480 OBDepict O O N S O O O IC50 = 20.0 nM 449.53 O=c1cc(-c2cccc3c2Sc2ccc(OC4COC4)cc2C3)oc(N2CCOCC2)c1 Homo sapiens CHEMBL4682233 single protein format
CHEMBL4858310 OBDepict H N O N N N H H H O Ki = 21.0 nM 352.44 O=c1cc(N2CCOCC2)nc(N2C[C@H]3C[C@H]3[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4794132 OBDepict O O N S O O CH 3 H N H CH 3 O H CH 3 IC50 = 24.0 nM 548.71 C[C@H]1CN(C[C@@H](C)Oc2ccc3c(c2)Cc2cccc(-c4cc(=O)cc(N5CCOCC5)o4)c2S3)C[C@@H](C)O1 Homo sapiens CHEMBL4682233 single protein format
CHEMBL1499544 OBDepict Cl N O S N H O Cl O CH 3 IC50 = 25.0 nM 477.41 COc1ccc(N(C(=O)CCl)C(C(=O)NCCc2ccccc2)c2cccs2)cc1Cl Homo sapiens CHEMBL4623300 single protein format
CHEMBL4792737 OBDepict CH 3 O S O O N O IC50 = 29.0 nM 407.49 COc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)o3)c1S2 Homo sapiens CHEMBL4682233 single protein format
CHEMBL1615189 OBDepict H 3 C NH O N S N N H Cl S O O F Ki = 31.0 nM 476.94 CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 Homo sapiens CHEMBL1775871 single protein format
CHEMBL3787013 OBDepict H 3 C HN O N S CH 3 S Cl NH O O HO IC50 = 32.0 nM 437.93 CC(=O)Nc1nc(C)c(-c2ccc(Cl)c(S(=O)(=O)Nc3ccc(O)cc3)c2)s1 Homo sapiens CHEMBL3789431 assay format
CHEMBL3781926 OBDepict H 3 C NH H 3 C CH 3 N N N N N H N IC50 = 35.0 nM 375.48 CC(C)(C)Nc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4874992 OBDepict CH 3 O S N OH N N O Ki = 35.0 nM 407.5 COc1ccc2c(c1)Cc1cccc(-c3cc(O)nc(N4CCOCC4)n3)c1S2 Homo sapiens CHEMBL4823701 assay format
CHEMBL3780029 OBDepict CH 3 N H N N N N N H N IC50 = 37.0 nM 333.4 CNc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4858974 OBDepict O N H N N H O F F Ki = 39.0 nM 375.42 O=c1cc(N2CCOCC2)cc(N2CCC(F)(F)[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4639853 OBDepict Cl N O N N H N N CH 3 H + N O _ O IC50 = 40.0 nM 346.73 Cc1cc(Nc2cc(Cl)nc(Oc3ccc([N+](=O)[O-])cc3)n2)n[nH]1 Homo sapiens CHEMBL4623302 cell-based format
CHEMBL4752634 OBDepict H 3 C O O H 3 C H S O O N O IC50 = 41.0 nM 465.57 COC[C@@H](C)Oc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)o3)c1S2 Homo sapiens CHEMBL4682233 single protein format
CHEMBL4873551 OBDepict O N H N N O Ki = 49.0 nM 339.44 O=c1cc(N2CCOCC2)cc(N2CCCC2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4872830 OBDepict H N O N N H O Ki = 50.0 nM 367.49 O=c1cc(N2CCOCC2)cc(N2CCCCC[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4783168 OBDepict F F N H O S O O N O IC50 = 67.0 nM 526.61 O=c1cc(-c2cccc3c2Sc2ccc(O[C@@H]4CCN(CC(F)F)C4)cc2C3)oc(N2CCOCC2)c1 Homo sapiens CHEMBL4682233 single protein format
CHEMBL3781615 OBDepict NH N N N N HN N IC50 = 76.0 nM 409.5 c1ccc(CNc2ncc(-c3ccnc(Nc4ccncc4)n3)c(CC3CC3)n2)cc1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL3913746 OBDepict Cl N N H N N N N N H OH CH 3 H 3 C IC50 = 76.0 nM 425.92 CC(C)(O)CNc1ncc(-c2ccnc(Nc3ccnc(Cl)c3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3861252 single protein format
CHEMBL4586628 OBDepict O CH 3 CH 3 N N N H F F F N O H H 3 C O IC50 = 82.0 nM 402.42 CC(C)C(=O)CN1c2nc(N3CCOC[C@H]3C)cc(=O)n2CC[C@H]1C(F)(F)F Homo sapiens CHEMBL4308986 cell-based format
CHEMBL3780339 OBDepict CH 3 H 3 C CH 3 NH N N N N N H N IC50 = 85.0 nM 389.51 CC(C)(C)CNc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL3781634 OBDepict CH 3 O N N N N N H N IC50 = 91.0 nM 334.38 COc1ncc(-c2ccnc(Nc3ccncc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4874640 OBDepict H N O N N H H H O Ki = 98.0 nM 351.45 O=c1cc(N2CCOCC2)cc(N2C[C@H]3C[C@H]3[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4866506 OBDepict O N H N N H O H F Ki = 110.0 nM 357.43 O=c1cc(N2CCOCC2)cc(N2CC[C@@H](F)[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL3781916 OBDepict CH 3 N H N N N N N H H H HO IC50 = 110.0 nM 354.46 CNc1ncc(-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL3781236 OBDepict CH 3 NH N N N N N H O CH 3 IC50 = 120.0 nM 362.44 CNc1ncc(-c2ccnc(Nc3ccc(OC)cc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4879094 OBDepict CH 3 O S N H N O O Ki = 130.0 nM 406.51 COc1ccc2c(c1)Cc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2 Homo sapiens CHEMBL4823701 assay format
CHEMBL3782016 OBDepict CH 3 N H N N N N N H N IC50 = 130.0 nM 383.46 CNc1ncc(-c2ccnc(Nc3cnc4ccccc4c3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL3787634 OBDepict HO N H S O O Br S CH 3 N N H O CH 3 IC50 = 146.0 nM 434.34 CC(=O)Nc1nc(C)c(-c2ccc(Br)c(S(=O)(=O)NCCO)c2)s1 Homo sapiens CHEMBL3789431 assay format
CHEMBL4846084 OBDepict O N H N N H O Ki = 170.0 nM 353.47 O=c1cc(N2CCOCC2)cc(N2CCCC[C@@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL3112866 OBDepict O N H H 3 C N N H N O O IC50 = 183.0 nM 354.41 C[C@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 Homo sapiens CHEMBL3119544 single protein format
CHEMBL3781020 OBDepict N N H N N N N IC50 = 210.0 nM 304.36 c1cc(Nc2nccc(-c3cncnc3CC3CC3)n2)ccn1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL3780762 OBDepict O N H N N N N N H N IC50 = 240.0 nM 403.49 c1cc(Nc2nccc(-c3cnc(NC4CCOCC4)nc3CC3CC3)n2)ccn1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL3787054 OBDepict H 3 C HN O N S CH 3 S Cl NH O O F IC50 = 245.4 nM 439.92 CC(=O)Nc1nc(C)c(-c2ccc(Cl)c(S(=O)(=O)Nc3ccc(F)cc3)c2)s1 Homo sapiens CHEMBL3789431 assay format
CHEMBL4852165 OBDepict OH N N N N H O Ki = 270.0 nM 340.43 Oc1cc(N2CCC[C@@H]2Cc2ccccc2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL4823701 assay format
CHEMBL3780896 OBDepict CH 3 N H N N N N N H IC50 = 290.0 nM 332.41 CNc1ncc(-c2ccnc(Nc3ccccc3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL1229535 OBDepict HO N H S O O Cl S CH 3 N N H O CH 3 IC50 = 307.0 nM 389.89 CC(=O)/N=c1/[nH]c(C)c(-c2ccc(Cl)c(S(=O)(=O)NCCO)c2)s1 Homo sapiens CHEMBL3789431 assay format
CHEMBL2387080 OBDepict CH 3 N N N CH 3 H 3 C N N O N N H 3 C H 3 C O H 2 N IC50 = 374.0 nM 460.54 Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 Homo sapiens CHEMBL2388240 single protein format
CHEMBL3781964 OBDepict CH 3 N H N N N N N H O IC50 = 400.0 nM 340.43 CNc1ncc(-c2ccnc(NC3CCOCC3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL4164334 OBDepict CH 3 H 3 C H 2 N H N H O N S CH 3 N N H Cl S O O CH 3 IC50 = 405.0 nM 494.04 Cc1ccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)cc1 Homo sapiens CHEMBL4156823 assay format
CHEMBL3780864 OBDepict CH 3 N H N N N N N H H H H 2 N IC50 = 410.0 nM 353.47 CNc1ncc(-c2ccnc(N[C@H]3CC[C@H](N)CC3)n2)c(CC2CC2)n1 Homo sapiens CHEMBL3784185 single protein format
CHEMBL1879463 OBDepict N H 3 C CH 3 N O N H 3 C N N IC50 = 450.0 nM 469.55 Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 Homo sapiens CHEMBL3861271 single protein format
CHEMBL2206921 OBDepict Cl N N H N N CH 3 N H 2 N N N H Cl S N O O H 3 C CH 3 IC50 = 606.0 nM 470.35 Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 Homo sapiens CHEMBL2211628 single protein format
CHEMBL4851518 OBDepict O N H N N H O Ki = 630.0 nM 339.44 O=c1cc(N2CCOCC2)cc(N2CCC[C@H]2Cc2ccccc2)[nH]1 Homo sapiens CHEMBL4823701 assay format
CHEMBL2391504 OBDepict F HN N N F IC50 = 740.0 nM 271.27 Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1 Homo sapiens CHEMBL4308983 single protein format
CHEMBL4856420 OBDepict H N O N N H H H O H H 3 C Ki = 750.0 nM 365.48 C[C@@H]1CN(c2cc(N3C[C@@H]4C[C@@H]4[C@@H]3Cc3ccccc3)[nH]c(=O)c2)CCO1 Homo sapiens CHEMBL4823701 assay format
CHEMBL1241857 OBDepict CH 3 O O N CH 3 HN N N O N IC50 = 830.0 nM 351.37 COc1ccc2c(c1OC)N=C(NC(=O)c1cccnc1)N1CCN=C21 Homo sapiens CHEMBL3861265 assay format
CHEMBL4161766 OBDepict CH 3 H 3 C H 2 N H N H O N S CH 3 N N H Cl S O O CH 3 IC50 = 834.0 nM 494.04 Cc1ccccc1S(=O)(=O)Nc1cc(-c2sc(NC(=O)[C@@H](N)C(C)C)nc2C)cnc1Cl Homo sapiens CHEMBL4156823 assay format
CHEMBL4852763 OBDepict H N O N N N H O H CH 3 Ki = 840.0 nM 382.51 C[C@@H]1CN(c2cc(=O)[nH]c(N3CCCCC[C@@H]3Cc3ccccc3)n2)CCO1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4867495 OBDepict H N O N N N H H H O H H 3 C Ki = 880.0 nM 366.46 C[C@@H]1CN(c2cc(=O)[nH]c(N3C[C@H]4C[C@H]4[C@@H]3Cc3ccccc3)n2)CCO1 Homo sapiens CHEMBL4823701 assay format
CHEMBL4872413 OBDepict CH 3 O S N H 3 C N O O Ki = 910.0 nM 420.53 COc1ccc2c(c1)Cc1cccc(-c3cc(N4CCOCC4)cc(=O)n3C)c1S2 Homo sapiens CHEMBL4823701 assay format
CHEMBL2216870 OBDepict CH 3 N H H N N N O N N N F H IC50 = 980.0 nM 415.43 CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 Homo sapiens CHEMBL4351101 single protein format