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Q8NI77 | KI18A_HUMAN | Kinesin-like protein KIF18A (KIF18A)

3D structures mapped by conservation among orthologs

[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Kinesin ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4776977 OBDepict OH S N H O O N N H O N F F IC50 = 12.0 nM 548.66 O=C(Nc1cccc(N2CCC(F)(F)CC2)c1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2 Homo sapiens CHEMBL4714848 assay format
CHEMBL4784192 OBDepict OH S N H O O N N H O N N CH 3 O IC50 = 12.0 nM 529.66 Cc1ccc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc1N1CCOCC1 Homo sapiens CHEMBL4731348 assay format
CHEMBL4755023 OBDepict HO NH S O O N N H O N O F F F IC50 = 12.0 nM 542.58 O=C(Nc1cccc(OCCC(F)(F)F)n1)c1ccc(S(=O)(=O)NCCO)cc1N1CCC2(CC1)CC2 Homo sapiens CHEMBL4731348 assay format
CHEMBL4777623 OBDepict CH 3 N HN N O F F N HN S O O H 3 C IC50 = 14.0 nM 505.59 Cc1cc(NC(=O)c2ccc(NS(C)(=O)=O)cc2N2CCC3(CC2)CC3)nc(N2CC(F)(F)C2)c1 Homo sapiens CHEMBL4731348 assay format
CHEMBL4752657 OBDepict OH S H 3 C H N H O O N N H O N O F F F IC50 = 14.0 nM 556.61 C[C@@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2cccc(OCCC(F)(F)F)n2)c(N2CCC3(CC2)CC3)c1 Homo sapiens CHEMBL4731348 assay format
CHEMBL4746340 OBDepict OH S H 3 C H N H O O N N H O N O F F F IC50 = 16.0 nM 556.61 C[C@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2cccc(OCCC(F)(F)F)n2)c(N2CCC3(CC2)CC3)c1 Homo sapiens CHEMBL4731348 assay format
CHEMBL4777759 OBDepict HO NH S O O N N H O N N O H H 3 C IC50 = 16.0 nM 529.66 C[C@@H]1CN(c2cccc(NC(=O)c3ccc(S(=O)(=O)NCCO)cc3N3CCC4(CC3)CC4)n2)CCO1 Homo sapiens CHEMBL4731348 assay format
CHEMBL4750775 OBDepict OH S N H O O N N H O N N F F IC50 = 17.0 nM 549.64 O=C(Nc1ccnc(N2CCC(F)(F)CC2)c1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2 Homo sapiens CHEMBL4731848 assay format
CHEMBL4779888 OBDepict OH S N H O O N N H O N H 3 C N F F IC50 = 17.0 nM 563.67 Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(C2CCC(F)(F)CC2)n1 Homo sapiens CHEMBL4731848 assay format
CHEMBL4751673 OBDepict OH S H 3 C H N H O O N N H O N N N O H H 3 C IC50 = 17.4 nM 544.68 C[C@@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2ccnc(N3CCO[C@H](C)C3)n2)c(N2CCC3(CC2)CC3)c1 Homo sapiens CHEMBL4731848 assay format
CHEMBL4776120 OBDepict OH S N H O O N N H O N H 3 C N N IC50 = 17.6 nM 540.69 Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(N2CCC3(CC3)C2)n1 Homo sapiens CHEMBL4731848 assay format
CHEMBL4743241 OBDepict OH S N H O O N N H O N H 3 C N O IC50 = 18.0 nM 515.64 Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(OC2CCC2)n1 Homo sapiens CHEMBL4731848 assay format
CHEMBL4740783 OBDepict OH S N H O O N N H O N H 3 C N N H CH 3 CH 3 OH IC50 = 18.0 nM 532.67 Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(NC(C)(C)CO)n1 Homo sapiens CHEMBL4731848 assay format
CHEMBL4759372 OBDepict OH S N H O O N NH O N IC50 = 26.0 nM 512.68 O=C(Nc1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2)c1cccc(N2CCCCC2)c1 Homo sapiens CHEMBL4714848 assay format
CHEMBL4757053 OBDepict O N H N HN S S HN O O CH 3 CH 3 CH 3 O O H 3 C CH 3 IC50 = 26.0 nM 562.76 CC(C)S(=O)(=O)Nc1ccc(C(=O)Nc2cccc(S(=O)(=O)NC(C)(C)C)c2)c(N2CCC3(CC2)CC3)c1 Homo sapiens CHEMBL4714848 assay format
CHEMBL4743666 OBDepict O N H N N H S S N H O O CH 3 CH 3 H 3 C O O CH 3 IC50 = 27.0 nM 534.7 CC(C)(C)NS(=O)(=O)c1cccc(NC(=O)c2ccc(NS(C)(=O)=O)cc2N2CCC3(CC2)CC3)c1 Homo sapiens CHEMBL4714848 assay format
CHEMBL4786845 OBDepict CH 3 HN S O O N N H O S NH O O H 3 C H 3 C CH 3 IC50 = 29.0 nM 534.7 CNS(=O)(=O)c1ccc(C(=O)Nc2cccc(S(=O)(=O)NC(C)(C)C)c2)c(N2CCC3(CC2)CC3)c1 Homo sapiens CHEMBL4714848 assay format
CHEMBL4765048 OBDepict OH S N H O O N N H O F N F F IC50 = 29.0 nM 566.65 O=C(Nc1cccc(N2CCC(F)(F)CC2)c1F)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2 Homo sapiens CHEMBL4714848 assay format