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Q8TCT8 | SPP2A_HUMAN | Signal peptide peptidase-like 2A (SPPL2A)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4059711 OBDepict O NH H 3 C H N H O F F H O N N IC50 = 5.0 nM 442.47 C[C@H](CC(=O)Nc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4762492 OBDepict H OH H 2 N H N S O O CH 3 CH 3 CH 3 IC50 = 7.0 nM 416.59 CC(C)(C)c1cccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccccc2)C2CCC2)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4759048 OBDepict F O F F NH 2 H OH H N S O O CH 3 CH 3 CH 3 IC50 = 9.0 nM 500.58 CC(C)(C)c1ccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccc(OC(F)(F)F)cc2)C2CCC2)cc1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL392068 OBDepict F F HO H NH O H 3 C H N H O H O N CH 3 IC50 = 10.0 nM 479.48 C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N(C)c2ccccc2-c2ccccc21 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4753654 OBDepict H HO H 2 N H N S O O CH 3 H 3 C CH 3 CH 3 IC50 = 13.0 nM 470.68 CC1(C)CCC(C)(C)c2cc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c3ccccc3)C3CCC3)ccc21 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4792187 OBDepict Cl Cl S N O O OH H H 2 N H IC50 = 15.0 nM 471.45 N[C@@H](c1ccccc1)[C@@H](O)CN(C1CCCCCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4759943 OBDepict H HO H 2 N H N S O O CH 3 CH 3 CH 3 IC50 = 25.0 nM 416.59 CC(C)(C)c1ccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccccc2)C2CCC2)cc1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4077007 OBDepict O NH CH 3 H N H O CH 3 H O N N IC50 = 35.0 nM 420.51 Cc1ccccc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4076827 OBDepict O NH CH 3 H N H O CH 3 N F H O N N IC50 = 44.0 nM 439.49 Cc1ncc(F)cc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4064631 OBDepict O NH CH 3 H N H O CH 3 H O N N IC50 = 70.0 nM 420.51 Cc1cccc(NC(=O)C[C@@H](C)C(=O)N[C@@H]2C(=O)N3CCCN3Cc3ccccc32)c1 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4100749 OBDepict O N H H 3 C H N H O CH 3 N F H O N N F IC50 = 76.0 nM 457.48 Cc1ncc(F)cc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2c(F)cccc21 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4069936 OBDepict O HN H N H O H 3 C N F H O N N O IC50 = 77.0 nM 505.55 Cc1ncc(F)cc1NC(=O)C[C@H](C(=O)N[C@@H]1C(=O)N2CC3(CC3)CN2C(=O)c2ccccc21)C1CC1 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4740837 OBDepict Cl Cl S N O O OH H NH 2 H IC50 = 88.0 nM 429.37 N[C@@H](c1ccccc1)[C@@H](O)CN(C1CCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4762370 OBDepict CH 3 H 3 C N S O O Cl Cl HO H H 2 N H IC50 = 200.0 nM 431.39 CC(C)CN(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4077336 OBDepict O N H H N H O CH 3 N F H O N N O IC50 = 225.0 nM 479.51 Cc1ncc(F)cc1NC(=O)C[C@H](C(=O)N[C@@H]1C(=O)N2CCCN2C(=O)c2ccccc21)C1CC1 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4747630 OBDepict CH 3 O H 3 C N S O O Cl Cl HO H H 2 N H IC50 = 350.0 nM 433.36 CC(C)ON(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4789381 OBDepict Cl Cl S N O O OH H H 2 N H IC50 = 620.0 nM 465.4 N[C@@H](c1ccccc1)[C@@H](O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4785324 OBDepict H OH NH 2 H N S O O N S IC50 = 840.0 nM 417.56 N[C@@H](c1ccccc1)[C@@H](O)CN(C1CCC1)S(=O)(=O)c1ccc2scnc2c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4743609 OBDepict H 3 C CH 3 N S O O Cl Cl OH H NH 2 H IC50 = 860.0 nM 445.41 CC(C)CN(C[C@H](O)[C@@H](N)Cc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4074838 OBDepict O N H H 3 C H N H O CH 3 N F H O N N O IC50 = 870.0 nM 453.47 Cc1ncc(F)cc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2C(=O)c2ccccc21 Homo sapiens CHEMBL4048263 cell-based format
CHEMBL4753079 OBDepict Cl Cl S N O O H 3 C OH H NH 2 H IC50 = 900.0 nM 443.4 CC1(N(C[C@H](O)[C@@H](N)c2ccccc2)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CCC1 Homo sapiens CHEMBL4667901 cell-based format
CHEMBL4798232 OBDepict Cl Cl S N O O OH H HO H 3 C CH 3 NH 2 H IC50 = 910.0 nM 447.38 CC(C)(O)CN(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL4667901 cell-based format