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Q8TDV5 | GP119_HUMAN | Glucose-dependent insulinotropic receptor (GPR119)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2382410 OBDepict N N O N N N N O O H 3 C CH 3 H 3 C IC50 = 1.0 nM 422.49 CC(C)(C)OC(=O)N1C2CCC1CN(c1ncc(OCc3ccncc3C#N)cn1)C2 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2086684 OBDepict N N O N N N H CH 3 N O O H 3 C H 3 C CH 3 IC50 = 1.0 nM 410.48 C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccncc2C#N)cn1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2086690 OBDepict N N O N N N H H 3 C N N N O CH 3 CH 3 IC50 = 3.0 nM 420.48 CC(C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)no1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2382409 OBDepict O N O CH 3 CH 3 CH 3 N N N O S O O CH 3 IC50 = 3.0 nM 474.58 CC(C)(C)OC(=O)N1C2CCC1CN(c1ncc(OCc3ccc(S(C)(=O)=O)cc3)cn1)C2 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2382417 OBDepict N N O N N N N N N O CH 3 H 3 C IC50 = 4.0 nM 432.49 CC(C)c1nc(N2C3CCC2CN(c2ncc(OCc4ccncc4C#N)cn2)C3)no1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2382412 OBDepict N N O N N N H CH 3 N O O F F F F IC50 = 6.0 nM 480.42 C[C@@H]1CN(C(=O)OC2CC(F)(F)C2(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2312159 OBDepict O N O H 3 C H 3 C CH 3 N N CH 3 N O F N N N N Ki = 7.0 nM 508.56 Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2382415 OBDepict N N O N N N N O O F F F IC50 = 8.0 nM 448.41 N#Cc1cnccc1COc1cnc(N2CC3CCC(C2)N3C(=O)OCC(F)(F)F)nc1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2382413 OBDepict N N O N N N N O O F F F F IC50 = 9.0 nM 492.43 N#Cc1cnccc1COc1cnc(N2CC3CCC(C2)N3C(=O)OC2CC(F)(F)C2(F)F)nc1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2204985 OBDepict N N N O N F N N N CH 3 Ki = 9.25 nM 431.48 CCc1cnc(N2CCC(n3ncc(COc4ccc(C#N)cc4F)c3C#N)CC2)nc1 Homo sapiens CHEMBL2208916 single protein format
CHEMBL2086680 OBDepict N N O N N N N O O CH 3 CH 3 CH 3 IC50 = 10.0 nM 396.45 CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccncc3C#N)cn2)CC1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2382416 OBDepict N N O N N N N N N O CH 3 H 3 C IC50 = 12.0 nM 406.45 CC(C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)CC2)no1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2204984 OBDepict N N N O N N N N N N N CH 3 Ki = 14.9 nM 456.51 CCc1cnc(N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)nc1 Homo sapiens CHEMBL2208916 single protein format
CHEMBL2312158 OBDepict O N O CH 3 N N H 3 C N O F N N N N Ki = 15.0 nM 506.54 Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2086660 OBDepict O N O CH 3 CH 3 CH 3 N H CH 3 N N O S O O CH 3 IC50 = 17.0 nM 462.57 C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2382414 OBDepict N N O N N N N O O F F F IC50 = 18.0 nM 422.37 N#Cc1cnccc1COc1cnc(N2CCN(C(=O)OCC(F)(F)F)CC2)nc1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2312506 OBDepict H 3 C N N N O H 3 C N N O O H 3 C CH 3 H 3 C Ki = 18.0 nM 451.57 CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312157 OBDepict H 3 C O H 3 C N O N N CH 3 N O F N N N N Ki = 18.0 nM 494.53 Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312156 OBDepict O N O CH 3 CH 3 H 3 C N N CH 3 N O N N N N Ki = 21.0 nM 490.57 Cc1c(Oc2ccc(-n3cnnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL1766081 OBDepict CH 3 O CH 3 N O O N CH 3 N O CH 3 N Ki = 23.0 nM 386.45 Cc1ncccc1Oc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C Homo sapiens CHEMBL1769549 cell-based format
CHEMBL2382411 OBDepict N N O N N N N O O F F F F IC50 = 25.0 nM 466.4 N#Cc1cnccc1COc1cnc(N2CCN(C(=O)OC3CC(F)(F)C3(F)F)CC2)nc1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2204983 OBDepict N N N O N O O N N CH 3 N N Ki = 29.8 nM 448.49 CC1(OC(=O)N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)CC1 Homo sapiens CHEMBL2208916 single protein format
CHEMBL2086687 OBDepict N N O N N N H H 3 C N O O F F F IC50 = 31.0 nM 436.39 C[C@@H]1CN(C(=O)OCC(F)(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2312161 OBDepict O N O H 3 C H 3 C CH 3 N N CH 3 N O F N N N Ki = 33.0 nM 507.57 Cc1c(Oc2ccc(-n3cncn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL1766082 OBDepict CH 3 O H 3 C N O O O N CH 3 N O CH 3 N Ki = 33.0 nM 428.49 Cc1ncccc1Oc1ncnc(OC2C3COCC2CN(C(=O)OC(C)C)C3)c1C Homo sapiens CHEMBL1769549 cell-based format
CHEMBL2204986 OBDepict N N N O N F O O N CH 3 Ki = 36.5 nM 423.45 CC1(OC(=O)N2CCC(n3ncc(COc4ccc(C#N)cc4F)c3C#N)CC2)CC1 Homo sapiens CHEMBL2208916 single protein format
CHEMBL2312517 OBDepict O N O CH 3 H 3 C CH 3 N N CH 3 N O F S O O CH 3 Ki = 41.0 nM 518.61 Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312516 OBDepict O N O CH 3 N N H 3 C N O N N N N Ki = 48.0 nM 488.55 Cc1c(Oc2ccc(-n3cnnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 Homo sapiens CHEMBL2320533 cell-based format
CHEMBL1951011 OBDepict H 3 C O CH 3 N O O N CH 3 N O F S O O CH 3 Ki = 53.0 nM 467.52 Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(C(=O)OC(C)C)CC1 Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2382408 OBDepict O N O H 3 C H 3 C CH 3 N N N O S O O CH 3 IC50 = 92.0 nM 474.58 CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2312515 OBDepict CH 3 O CH 3 N O N N CH 3 N O N N N N Ki = 94.0 nM 476.54 Cc1c(Oc2ccc(-n3cnnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2204982 OBDepict N N N O N F O O N N CH 3 N H 3 C N Ki = 99.0 nM 480.5 Cn1nnnc1-c1ccc(OCc2cnn(C3CCN(C(=O)OC4(C)CC4)CC3)c2C#N)c(F)c1 Homo sapiens CHEMBL2208916 single protein format
CHEMBL2312505 OBDepict CH 3 N N N O H 3 C N N O O H 3 C Ki = 123.0 nM 449.56 CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2311545 OBDepict O N O CH 3 CH 3 H 3 C N N CH 3 N O N N N Ki = 125.0 nM 489.58 Cc1c(Oc2ccc(-n3cncn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312519 OBDepict O N O H 3 C N N CH 3 N O F S O O CH 3 Ki = 131.0 nM 516.6 Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312513 OBDepict N F O N CH 3 N N N O O H 3 C H 3 C CH 3 Ki = 133.0 nM 465.53 Cc1c(Oc2ccc(C#N)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312528 OBDepict O N O CH 3 N N H 3 C N O H 3 C N Ki = 136.0 nM 449.56 Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CCC2)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312518 OBDepict H 3 C O CH 3 N O N N CH 3 N O F S O O CH 3 Ki = 141.0 nM 504.58 Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312511 OBDepict H 3 C O N N N O H 3 C N N O O H 3 C CH 3 H 3 C Ki = 163.0 nM 453.54 COc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312504 OBDepict CH 3 N N N O CH 3 N N O O CH 3 H 3 C Ki = 197.0 nM 437.54 CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312525 OBDepict H 3 C H 3 C O N O N N CH 3 N O CH 3 N Ki = 231.0 nM 437.54 Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OCC(C)C)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312526 OBDepict CH 3 O H 3 C H N O N N CH 3 N O CH 3 N Ki = 290.0 nM 437.54 CC[C@@H](C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312514 OBDepict CH 3 O CH 3 N O N N CH 3 N O N N N Ki = 294.0 nM 475.55 Cc1c(Oc2ccc(-n3ccnn3)cc2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2086650 OBDepict O N O CH 3 CH 3 CH 3 N N N O S O O CH 3 IC50 = 351.0 nM 448.55 CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccc(S(C)(=O)=O)cc3)cn2)CC1 Homo sapiens CHEMBL2382543 cell-based format
CHEMBL2312524 OBDepict O N O H 3 C CH 3 H 3 C N N CH 3 N O CH 3 N Ki = 486.0 nM 437.54 Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC(C)(C)C)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312527 OBDepict CH 3 O H 3 C H N O N N CH 3 N O CH 3 N Ki = 493.0 nM 437.54 CC[C@H](C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312501 OBDepict H 3 C N N N F O N CH 3 N N N O O CH 3 H 3 C CH 3 Ki = 507.0 nM 521.6 Cc1ncn(-c2ccc(Oc3ncnc(N4C5CC6CC4CC(C5)N6C(=O)OC(C)(C)C)c3C)c(F)c2)n1 Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312522 OBDepict O N O CH 3 N N H 3 C N O CH 3 N Ki = 586.0 nM 435.53 Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CC2)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312523 OBDepict O N O N N CH 3 N O CH 3 N Ki = 682.0 nM 435.53 Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2CCC2)c1C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312508 OBDepict O N O H 3 C CH 3 H 3 C N N F N O CH 3 N Ki = 814.0 nM 441.51 Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC(C)(C)C)c1F Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312512 OBDepict N F O N CH 3 N N N O O CH 3 H 3 C Ki = 912.0 nM 451.5 Cc1c(Oc2ccc(C#N)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C Homo sapiens CHEMBL2320533 cell-based format
CHEMBL2312162 OBDepict CH 3 N N N O N CH 3 N N N O O H 3 C H 3 C H 3 C Ki = 948.0 nM 503.61 Cc1ncn(-c2ccc(Oc3ncnc(N4C5CC6CC4CC(C5)N6C(=O)OC(C)(C)C)c3C)cc2)n1 Homo sapiens CHEMBL2320533 cell-based format