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Q92633 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPAR1)

3D structures mapped by conservation among orthologs

[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_3 ]

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[ Domain: "Cytochromes" // Cytochrom_B562_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3966526 OBDepict H 3 C O O N O O HO F IC50 = 0.3 nM 513.57 COc1ccccc1Oc1ccc(C(=O)N(CCCc2cccc(F)c2)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3943133 OBDepict F N O O O HO F IC50 = 0.4 nM 501.53 O=C(O)c1ccc(CN(CCCc2cccc(F)c2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3980736 OBDepict O N O O OH F IC50 = 1.0 nM 495.55 O=C(O)c1ccc(CN(CC2CC2c2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3936755 OBDepict H 3 C O O N O O HO IC50 = 2.0 nM 495.58 COc1ccccc1Oc1ccc(C(=O)N(CCCc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3911605 OBDepict H 3 C O N O O O HO F IC50 = 2.0 nM 485.51 COc1ccc(CN(Cc2ccc(C(=O)O)cc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3901720 OBDepict H 3 C O O N O F F F O OH IC50 = 4.0 nM 459.42 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(F)(F)F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3945517 OBDepict CH 3 O O N O O OH IC50 = 4.0 nM 431.49 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3900559 OBDepict CH 3 O N O O O HO F IC50 = 4.0 nM 485.51 COc1cccc(CN(Cc2ccc(C(=O)O)cc2)C(=O)c2ccc(Oc3ccccc3F)cc2)c1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3920849 OBDepict CH 3 N O O O O CH 3 O H 3 C IC50 = 5.0 nM 447.53 CCCCN(Cc1ccc(C(=O)OC)cc1)C(=O)c1ccc(Oc2ccccc2OC)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3961765 OBDepict CH 3 N O O O OH O H 3 C IC50 = 5.0 nM 419.48 CCCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2OC)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3891550 OBDepict O N O F O OH IC50 = 6.0 nM 455.49 O=C(O)c1ccc(CN(Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3955284 OBDepict O N HO H O O OH F IC50 = 7.0 nM 499.54 O=C(O)c1ccc(CN(C[C@@H](O)Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3980174 OBDepict CH 3 O O F N O O OH IC50 = 7.0 nM 449.48 COc1cccc(F)c1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3892760 OBDepict H 3 C O O N O F F CH 3 O OH IC50 = 7.0 nM 455.46 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(C)(F)F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3910049 OBDepict CH 3 O O F N O O OH IC50 = 7.0 nM 449.48 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)c(F)c1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3987061 OBDepict H 3 C O O N O F F F O OH IC50 = 9.0 nM 473.45 COc1ccccc1Oc1ccc(C(=O)N(CCC(F)(F)F)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3942894 OBDepict O N O CH 3 O HO IC50 = 11.0 nM 451.52 Cc1ccccc1Oc1ccc(C(=O)N(Cc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL4113366 OBDepict O N HO H O O OH F IC50 = 12.0 nM 499.54 O=C(O)c1ccc(CN(C[C@H](O)Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3985179 OBDepict CH 3 O O N N O O OH IC50 = 12.0 nM 432.48 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)nc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3942192 OBDepict CH 3 O O N O CH 3 H 3 C O OH IC50 = 12.0 nM 433.5 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(C)C)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3918970 OBDepict CH 3 O O F N O O OH IC50 = 13.0 nM 449.48 COc1cc(F)ccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3971670 OBDepict O N O O OH CH 3 IC50 = 14.0 nM 465.55 Cc1ccccc1Oc1ccc(C(=O)N(CCc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3908908 OBDepict CH 3 O O H H N O O OH F IC50 = 17.0 nM 519.61 COc1ccccc1O[C@H]1CC[C@H](C(=O)N(CCCc2cccc(F)c2)Cc2ccc(C(=O)O)cc2)CC1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3920547 OBDepict O N O CH 3 H 3 C O HO IC50 = 19.0 nM 465.55 Cc1cccc(C)c1Oc1ccc(C(=O)N(Cc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3911962 OBDepict O N O O OH CH 3 CH 3 IC50 = 22.0 nM 479.58 Cc1cccc(C)c1Oc1ccc(C(=O)N(CCc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3979729 OBDepict O N O O OH Cl IC50 = 24.0 nM 485.97 O=C(O)c1ccc(CN(CCc2ccccc2)C(=O)c2ccc(Oc3ccccc3Cl)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3909531 OBDepict O N O O OH F F IC50 = 25.0 nM 437.44 O=C(O)c1ccc(CN(CC2CC2)C(=O)c2ccc(Oc3c(F)cccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3900867 OBDepict F O N O F O OH IC50 = 27.0 nM 437.44 O=C(O)c1ccc(CN(CC2CC2)C(=O)c2ccc(Oc3ccccc3F)cc2F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3933337 OBDepict O N F F F O O OH Cl IC50 = 29.0 nM 463.84 O=C(O)c1ccc(CN(CC(F)(F)F)C(=O)c2ccc(Oc3ccccc3Cl)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3967394 OBDepict O N O O OH CH 3 IC50 = 30.0 nM 415.49 Cc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3915509 OBDepict CH 3 N O O O OH F IC50 = 31.0 nM 421.47 CCCCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3975980 OBDepict CH 3 N O O O OH F IC50 = 33.0 nM 407.44 CCCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3963944 OBDepict CH 3 O O N O F F O OH IC50 = 34.0 nM 441.43 COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(F)F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3959098 OBDepict O N F F F O O OH F IC50 = 35.0 nM 447.38 O=C(O)c1ccc(CN(CC(F)(F)F)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3893992 OBDepict O N O O HO F F IC50 = 36.0 nM 451.47 O=C(O)c1ccc(CN(CCC2CC2)C(=O)c2ccc(Oc3c(F)cccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3943469 OBDepict O N F F CH 3 O O OH F IC50 = 40.0 nM 443.42 CC(F)(F)CN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3923068 OBDepict CH 3 N O O O OH O CH 3 IC50 = 46.0 nM 405.45 CCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2OC)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3986752 OBDepict O N O O OH F IC50 = 46.0 nM 419.45 O=C(O)c1ccc(CN(CC2CC2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3890476 OBDepict CH 3 CH 3 N O O O OH F IC50 = 46.0 nM 435.5 CC(C)CCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3924401 OBDepict O N F F F O O HO CH 3 IC50 = 47.0 nM 443.42 Cc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(F)(F)F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL604677 OBDepict OH O O N O O + N O _ O Ki = 48.0 nM 404.33 O=C(O)c1ccc2c(c1)C(=O)N(c1cccc(Oc3ccc([N+](=O)[O-])cc3)c1)C2=O Homo sapiens CHEMBL1064669 single protein format
CHEMBL3948456 OBDepict CH 3 H 3 C N O O O OH F IC50 = 49.0 nM 421.47 CC(C)CN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2F)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL4871014 OBDepict HO O N H 3 C H O F F F H H F F F IC50 = 53.0 nM 543.55 C[C@@H](c1ccc2ccc(O[C@H]3CC[C@@H](C(F)(F)F)CC3)c(C(F)(F)F)c2c1)N1C2CCC1CC(C(=O)O)C2 Homo sapiens CHEMBL4827706 cell-free format
CHEMBL3896384 OBDepict O N F F F O O OH F IC50 = 59.0 nM 461.41 O=C(O)c1ccc(CN(CCC(F)(F)F)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3942946 OBDepict CH 3 H 3 C N O O O HO CH 3 H 3 C IC50 = 75.0 nM 445.56 Cc1cccc(C)c1Oc1ccc(C(=O)N(CCC(C)C)Cc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3972525 OBDepict O N N O O OH F IC50 = 86.0 nM 420.44 O=C(O)c1ccc(CN(CC2CC2)C(=O)c2ccc(Oc3ccccc3F)cn2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3921376 OBDepict CH 3 O O F N O O OH IC50 = 94.0 nM 449.48 COc1ccc(F)cc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3985727 OBDepict CH 3 N O O O OH O H 3 C F IC50 = 110.0 nM 437.47 CCCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccc(F)cc2OC)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3908939 OBDepict CH 3 N O O O OH CH 3 IC50 = 120.0 nM 389.45 CCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2C)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3942927 OBDepict CH 3 N O O O OH Cl IC50 = 130.0 nM 409.87 CCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2Cl)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL427017 OBDepict CH 3 O O H O P S OH OH H 3 C Ki = 139.0 nM 412.57 CCCCCCCCOC[C@@H](COP(O)(O)=S)OCCCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL440396 OBDepict CH 3 N H O NH H O O P S HO OH H 3 C Ki = 152.0 nM 438.57 CCCCCCCCNC(=O)[C@H](COP(O)(O)=S)NC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL3966386 OBDepict O N O CH 3 F O OH IC50 = 160.0 nM 433.48 Cc1cccc(F)c1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3897650 OBDepict CH 3 O O N N N O O OH IC50 = 170.0 nM 433.46 COc1ccccc1Oc1cnc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)nc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL3935056 OBDepict CH 3 N O N N O O OH O H 3 C IC50 = 180.0 nM 421.45 CCCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ncc(Oc2ccccc2OC)cn1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL383095 OBDepict H 3 C O O O H O O P O OH OH CH 3 Ki = 221.0 nM 424.47 CCCCCCCC(=O)OC[C@@H](COP(=O)(O)O)OC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL607806 OBDepict HO O N O O O CH 3 Ki = 311.0 nM 311.29 Cc1ccc(Oc2ccc3c(c2)C(=O)N(CC(=O)O)C3=O)cc1 Homo sapiens CHEMBL1064669 single protein format
CHEMBL427017 OBDepict CH 3 O O H O P S OH OH H 3 C IC50 = 328.0 nM 412.57 CCCCCCCCOC[C@@H](COP(O)(O)=S)OCCCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL202361 OBDepict CH 3 O O O H O O P S HO OH H 3 C Ki = 360.0 nM 440.54 CCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL3948271 OBDepict F F N O O O OH Cl IC50 = 390.0 nM 445.85 O=C(O)c1ccc(CN(CC(F)F)C(=O)c2ccc(Oc3ccccc3Cl)cc2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL202185 OBDepict H 3 C O O O H O O P O OH OH CH 3 Ki = 407.0 nM 424.47 CCCCCCCC(=O)OC[C@H](COP(=O)(O)O)OC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL361501 OBDepict HO O S O N N H CH 3 O O CH 3 Cl Ki = 425.0 nM 474.97 Cc1noc(-c2ccc(CSCCC(=O)O)cc2)c1NC(=O)OC(C)c1ccccc1Cl Homo sapiens CHEMBL829831 cell-based format
CHEMBL383095 OBDepict H 3 C O O O H O O P O OH OH CH 3 IC50 = 433.0 nM 424.47 CCCCCCCC(=O)OC[C@@H](COP(=O)(O)O)OC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL188591 OBDepict CH 3 O P O OH OH Ki = 457.0 nM 292.36 CC/C=C/CCCCCCCCCCOP(=O)(O)O Homo sapiens CHEMBL829831 cell-based format
CHEMBL440396 OBDepict CH 3 N H O NH H O O P S HO OH H 3 C IC50 = 476.0 nM 438.57 CCCCCCCCNC(=O)[C@H](COP(O)(O)=S)NC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL203986 OBDepict H 3 C O O H O P O OH HO CH 3 Ki = 486.0 nM 396.51 CCCCCCCCOC[C@@H](COP(=O)(O)O)OCCCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL3907299 OBDepict O N N N O O OH F IC50 = 540.0 nM 421.43 O=C(O)c1ccc(CN(CC2CC2)C(=O)c2ncc(Oc3ccccc3F)cn2)cc1 Homo sapiens CHEMBL3889172 cell-based format
CHEMBL202361 OBDepict CH 3 O O O H O O P S HO OH H 3 C IC50 = 686.0 nM 440.54 CCCCCCCC(=O)OC[C@H](COP(O)(O)=S)OC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL202185 OBDepict H 3 C O O O H O O P O OH OH CH 3 IC50 = 692.0 nM 424.47 CCCCCCCC(=O)OC[C@H](COP(=O)(O)O)OC(=O)CCCCCCC Homo sapiens CHEMBL864091 cell-based format
CHEMBL188859 OBDepict CH 3 P F F O OH HO Ki = 788.0 nM 328.38 CCCCCCCCCCCCCCC(F)(F)P(=O)(O)O Homo sapiens CHEMBL829831 cell-based format