Q92743 | HTRA1_HUMAN | Serine protease HTRA1 (HTRA1)

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_2 ]

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[ Domain: "Kazal-type serine protease inhibitors" // Kazal_1_1 ]

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[ Domain: "Growth factor receptor domain" // IGFBP ]

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[ Domain: "PDZ domain" // PDZ_2 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4520468		IC50	=	4.0	nM	597.57	CC(C)[C@H](NC(=O)[C@@H]1C[C@H](c2ccccc2)CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O	Homo sapiens	CHEMBL4418436	single protein format
CHEMBL4466195		IC50	=	8.95	nM	575.41	CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](OCc2ccccc2)CN1C(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F	Homo sapiens	CHEMBL4418458	cell-based format
CHEMBL4446596		IC50	=	10.0	nM	595.55	CC(C)[C@H](NC(=O)C1C=C(c2ccccc2)CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O	Homo sapiens	CHEMBL4418436	single protein format
CHEMBL4570179		IC50	=	16.0	nM	561.53	CC(C)[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O	Homo sapiens	CHEMBL4418436	single protein format
CHEMBL4444523		IC50	=	19.6	nM	573.44	CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](OCc2ccccc2)CN1C(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F	Homo sapiens	CHEMBL4418458	cell-based format
CHEMBL4474054		IC50	=	60.0	nM	555.91	CC(C)[C@H](NC(=O)[C@@H]1C[C@H](Cl)CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O	Homo sapiens	CHEMBL4418436	single protein format