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Q92800 | EZH1_HUMAN | Histone-lysine N-methyltransferase EZH1 (EZH1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3360855 OBDepict O N H N N H 3 C O N H CH 3 N O IC50 = 45.0 nM 539.68 Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CN4CCOCC4)cc3)cc3c2cnn3C2CCCC2)c(=O)[nH]1 Homo sapiens CHEMBL4735337 single protein format
CHEMBL4297463 OBDepict CH 3 O CH 3 N NH O H O CH 3 N CH 3 H N F F F IC50 = 52.0 nM 518.58 COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2ccccc12 Homo sapiens CHEMBL4766109 single protein format
CHEMBL4594174 OBDepict CH 3 CH 3 N HN O H O N N N CH 3 H 3 C N HN IC50 = 60.0 nM 527.67 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCNCC3)nc2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL3414619 OBDepict CH 3 CH 3 N HN O H O N N N CH 3 H 3 C N N H 3 C CH 3 IC50 = 69.0 nM 569.75 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4080228 OBDepict CH 3 O H 3 C N N O H O Cl Cl O H CH 3 O Ki = 70.0 nM 467.35 COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@H](OC)C3COC3)c(Cl)c2C1=O Homo sapiens CHEMBL4027425 single protein format
CHEMBL4567859 OBDepict CH 3 N H 3 C N N N HN O N H 3 C CH 3 O N H CH 3 IC50 = 86.0 nM 595.79 Cc1cc(C2CCCC2)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1 Homo sapiens CHEMBL4479463 single protein format
CHEMBL4557033 OBDepict CH 3 CH 3 N HN O H O N N N CH 3 H 3 C N N H 3 C IC50 = 88.0 nM 555.73 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(CC)CC3)nc2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4559875 OBDepict H 3 C H 3 C N N H O H O N N N N N CH 3 H 3 C IC50 = 108.0 nM 595.79 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C1CCCC1 Homo sapiens CHEMBL4479463 single protein format
CHEMBL4545986 OBDepict CH 3 CH 3 N HN O H O N N N CH 3 H 3 C N N H 3 C CH 3 IC50 = 126.0 nM 597.81 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(CC)CC Homo sapiens CHEMBL4479463 single protein format
CHEMBL4539055 OBDepict CH 3 CH 3 N HN O H O N N N H 3 C H 3 C CH 3 N N H 3 C CH 3 IC50 = 127.0 nM 583.78 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4554286 OBDepict H 3 C CH 3 N HN O H O N N N CH 3 H 3 C N N H 3 C CH 3 IC50 = 160.0 nM 583.78 CCCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4551319 OBDepict CH 3 CH 3 CH 3 N HN O H O N N N CH 3 H 3 C N N H 3 C CH 3 IC50 = 211.0 nM 583.78 Cc1cc(CC(C)C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1 Homo sapiens CHEMBL4479463 single protein format
CHEMBL4559801 OBDepict CH 3 N H 3 C N N N NH O N H 3 C CH 3 O N CH 3 H 3 C H CH 3 IC50 = 320.0 nM 569.75 Cc1cc(C(C)C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1 Homo sapiens CHEMBL4479463 single protein format
CHEMBL4569399 OBDepict CH 3 CH 3 N N H O H O N N H 3 C H 3 C N H IC50 = 613.0 nM 449.6 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(C2CCNCC2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4542135 OBDepict CH 3 CH 3 N N H O H O N N N H 3 C H 3 C IC50 = 681.0 nM 443.55 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccccn2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4593352 OBDepict CH 3 CH 3 N N H O H O N N N H 3 C H 3 C F IC50 = 773.0 nM 461.54 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(F)cn2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4544978 OBDepict CH 3 CH 3 N NH O H O N N N H 3 C CH 3 N N CH 3 CH 3 IC50 = 810.0 nM 555.73 CCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format
CHEMBL4575460 OBDepict CH 3 CH 3 N N H O H O N N N H 3 C H 3 C N H IC50 = 880.0 nM 450.59 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(N2CCNCC2)cc2c1cnn2C(C)C Homo sapiens CHEMBL4479463 single protein format