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Q96L34 | MARK4_HUMAN | MAP/microtubule affinity-regulating kinase 4 (MARK4)

3D structures mapped by conservation among orthologs

[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_MELK ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -1100.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804428 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -500.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804428 cell-based format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 0.114 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328486 single protein format
CHEMBL3884319 OBDepict HO H N N O CH 3 H 3 C N NH IC50 = 21.0 nM 386.45 CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876024 cell-based format
CHEMBL3884344 OBDepict O N H 3 C H 3 C N H N NH N H S O O CH 3 IC50 = 180.0 nM 463.56 CC1(C)C(=O)N([C@H]2CCc3c(NS(C)(=O)=O)cccc32)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876024 cell-based format
CHEMBL3884318 OBDepict HO N CH 3 H N O CH 3 H 3 C N NH N IC50 = 270.0 nM 375.43 C[C@@H](c1cccc(O)c1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876024 cell-based format
CHEMBL3883979 OBDepict H 2 N H N N O CH 3 H 3 C N NH IC50 = 450.0 nM 385.47 CC1(C)C(=O)N([C@H]2CCc3c(N)cccc32)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876024 cell-based format
CHEMBL3883433 OBDepict O N CH 3 H 3 C N H N NH N IC50 = 520.0 nM 371.44 CC1(C)C(=O)N([C@H]2CCc3ccccc32)c2nc(Nc3cccnc3)ncc21 Homo sapiens CHEMBL3876024 cell-based format
CHEMBL3884535 OBDepict O N H 3 C H 3 C N N HN N NH IC50 = 920.0 nM 420.56 CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccc(N4CCNCC4)c3)ncc21 Homo sapiens CHEMBL3876024 cell-based format