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Q96LA8 | ANM6_HUMAN | Protein arginine N-methyltransferase 6 (PRMT6)

3D structures mapped by conservation among orthologs

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]

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[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4094513 OBDepict NH 2 N CH 3 S Cl IC50 = 1.2 nM 306.86 CN(CCN)Cc1ccccc1Sc1ccccc1Cl Homo sapiens CHEMBL4026504 single protein format
CHEMBL3589043 OBDepict H 3 C NH N H 3 C N N H O N O H 3 C CH 3 IC50 = 2.0 nM 407.52 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589029 OBDepict NH 2 N H 3 C N N H O IC50 = 2.0 nM 322.41 CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589042 OBDepict H 3 C NH N H 3 C N N H O N O H 3 C CH 3 IC50 = 3.0 nM 407.52 CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3901808 OBDepict NH 2 N CH 3 N H O H 3 C CH 3 IC50 = 4.0 nM 287.41 CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 Homo sapiens CHEMBL3859040 single protein format
CHEMBL3590417 OBDepict CH 3 HN N CH 3 N N H O N H O CH 3 IC50 = 5.0 nM 393.49 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589026 OBDepict NH 2 N CH 3 N N H O CH 3 H 3 C IC50 = 7.0 nM 288.4 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589030 OBDepict NH 2 N CH 3 N N H Cl O CH 3 H 3 C IC50 = 8.0 nM 322.84 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1Cl Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589031 OBDepict CH 3 HN N CH 3 N N H Cl O CH 3 H 3 C IC50 = 10.0 nM 336.87 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589028 OBDepict NH 2 N CH 3 N N H CH 3 H 3 C IC50 = 10.0 nM 286.42 CC(C)Cc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589039 OBDepict CH 3 NH N H 3 C N N H O H H O O IC50 = 10.0 nM 442.6 CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@H](OCCC3CCOCC3)C2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589027 OBDepict CH 3 HN N CH 3 N N H O H 3 C CH 3 IC50 = 11.0 nM 302.42 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589912 OBDepict H 2 N N CH 3 N N H F IC50 = 11.0 nM 248.31 CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589040 OBDepict H 2 N N CH 3 N N H O N O IC50 = 13.0 nM 373.5 CN(CCN)Cc1c[nH]nc1-c1ccc(OCCCN2CCOCC2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL4463793 OBDepict NH 2 N CH 3 N H NH O H 2 C Ki = 16.0 nM 298.39 C=CC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346579 single protein format
CHEMBL4463793 OBDepict NH 2 N CH 3 N H NH O H 2 C IC50 = 18.0 nM 298.39 C=CC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346578 single protein format
CHEMBL3589041 OBDepict H 2 N N CH 3 N N H N N O IC50 = 20.0 nM 432.57 CN(CCN)Cc1c[nH]nc1-c1ccc(N2CCN(C(=O)Cc3ccccc3)CC2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589032 OBDepict CH 3 HN N CH 3 N N CH 3 Cl O CH 3 H 3 C IC50 = 23.0 nM 350.89 CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3906680 OBDepict CH 3 HN N O Br IC50 = 25.0 nM 327.27 CNCCN1CCC(OCc2ccccc2Br)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3956007 OBDepict H 3 C NH N O N N H 3 C H 3 C IC50 = 25.0 nM 342.49 CNCCN1CCC(OCc2ccc(-n3nc(C)cc3C)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3589913 OBDepict H 3 C NH N H 3 C N N H O CH 3 IC50 = 25.0 nM 288.4 CCOc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589033 OBDepict H 3 C NH N H 3 C N N H O OH CH 3 IC50 = 25.0 nM 332.45 CCC(CO)Oc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3984626 OBDepict CH 3 NH N O O Cl Cl IC50 = 26.0 nM 409.36 CNCCN1CCC(OCc2ccc(Oc3cccc(Cl)c3Cl)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3957029 OBDepict CH 3 NH N O IC50 = 27.0 nM 324.47 CNCCN1CCC(OCc2ccc(-c3ccccc3)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL4544587 OBDepict NH 2 N CH 3 N H NH O H 3 C IC50 = 28.0 nM 300.41 CCC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346578 single protein format
CHEMBL3939593 OBDepict CH 3 NH N O IC50 = 28.0 nM 330.52 CNCCN1CCC(OCc2ccc(C3CCCCC3)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3970878 OBDepict CH 3 N H N O IC50 = 30.0 nM 324.47 CNCCN1CCC(OCc2cccc(-c3ccccc3)c2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3952337 OBDepict CH 3 HN N O Cl IC50 = 30.0 nM 282.82 CNCCN1CCC(OCc2ccccc2Cl)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3589034 OBDepict CH 3 HN N CH 3 N N H O CH 3 H 3 C HO IC50 = 32.0 nM 346.48 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(CO)C(C)C)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3924657 OBDepict CH 3 NH N O F IC50 = 38.0 nM 266.36 CNCCN1CCC(OCc2ccc(F)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3943629 OBDepict CH 3 NH N O Cl IC50 = 40.0 nM 282.82 CNCCN1CCC(OCc2ccc(Cl)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3938938 OBDepict CH 3 NH N O Br IC50 = 44.0 nM 327.27 CNCCN1CCC(OCc2ccc(Br)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3929454 OBDepict CH 3 NH N O O F F F IC50 = 46.0 nM 332.37 CNCCN1CCC(OCc2ccc(OC(F)(F)F)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3928539 OBDepict CH 3 HN N O F IC50 = 47.0 nM 266.36 CNCCN1CCC(OCc2ccccc2F)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3930600 OBDepict CH 3 NH N O O F F F IC50 = 48.0 nM 346.39 CNCCN1CCC(OCc2ccc(OCC(F)(F)F)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3948358 OBDepict CH 3 NH N O IC50 = 48.0 nM 324.47 CNCCN1CCC(OCc2ccccc2-c2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3983725 OBDepict CH 3 HN N O Br IC50 = 53.0 nM 327.27 CNCCN1CCC(OCc2cccc(Br)c2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3955728 OBDepict CH 3 HN N O F IC50 = 56.0 nM 266.36 CNCCN1CCC(OCc2cccc(F)c2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3892699 OBDepict CH 3 NH N IC50 = 56.0 nM 246.4 CNCCN1CCC(CCc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3925764 OBDepict CH 3 HN N O F F F IC50 = 64.0 nM 316.37 CNCCN1CCC(OCc2ccccc2C(F)(F)F)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL4068717 OBDepict H 3 C N H N NH IC50 = 67.0 nM 295.43 CNCCN1CC(NCc2cccc(-c3ccccc3)c2)C1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3911620 OBDepict CH 3 HN N O CH 3 CH 3 CH 3 IC50 = 67.0 nM 318.51 CCC(C)(C)c1ccc(COC2CCN(CCNC)CC2)cc1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3969797 OBDepict CH 3 N H N IC50 = 70.0 nM 218.34 CNCCN1CCC(Cc2ccccc2)C1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3902609 OBDepict CH 3 NH N O H 3 C CH 3 IC50 = 72.0 nM 304.48 CNCCN1CCC(OCc2ccc(CC(C)C)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3915667 OBDepict CH 3 HN N O Cl IC50 = 78.0 nM 282.82 CNCCN1CCC(OCc2cccc(Cl)c2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3889478 OBDepict CH 3 NH N O IC50 = 90.0 nM 234.34 CNCCN1CCC(Oc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3981736 OBDepict CH 3 NH N O IC50 = 92.0 nM 248.37 CNCCN1CCC(COc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL4071435 OBDepict H 3 C NH N N H F IC50 = 101.0 nM 237.32 CNCCN1CC(NCc2cccc(F)c2)C1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3910681 OBDepict CH 3 NH N O O IC50 = 107.0 nM 262.35 CNCCN1CCC(OC(=O)c2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3964631 OBDepict CH 3 NH N N H IC50 = 116.0 nM 247.39 CNCCN1CCC(CNc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3960002 OBDepict CH 3 NH N O F F F IC50 = 117.0 nM 316.37 CNCCN1CCC(OCc2cccc(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL4096482 OBDepict CH 3 N H N HN IC50 = 120.0 nM 323.48 CNCCN1CCC(NCc2cccc(-c3ccccc3)c2)CC1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3961070 OBDepict CH 3 NH N N H O IC50 = 129.0 nM 261.37 CNCCN1CCC(NC(=O)c2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL4098465 OBDepict H 3 C NH N N H Cl IC50 = 133.0 nM 253.78 CNCCN1CC(NCc2cccc(Cl)c2)C1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3890919 OBDepict CH 3 NH N O F F F IC50 = 144.0 nM 316.37 CNCCN1CCC(OCc2ccc(C(F)(F)F)cc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3936550 OBDepict CH 3 NH N IC50 = 170.0 nM 232.37 CNCCN1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3924501 OBDepict CH 3 NH N N H IC50 = 186.0 nM 233.36 CNCCN1CCC(Nc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3780926 OBDepict NH 2 N IC50 = 230.0 nM 218.34 NCCN1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL3784078 cell-based format
CHEMBL4081966 OBDepict H 3 C NH N N H Br IC50 = 249.0 nM 298.23 CNCCN1CC(NCc2cccc(Br)c2)C1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3925616 OBDepict CH 3 N H N IC50 = 290.0 nM 232.37 CNCCN1CCCC(Cc2ccccc2)C1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3589035 OBDepict H 2 N N H 3 C N N H Cl O F F F CH 3 H 3 C IC50 = 320.0 nM 390.84 CC(C)Oc1c(Cl)cc(-c2c[nH]nc2CN(C)CCN)cc1C(F)(F)F Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589036 OBDepict CH 3 N H N H 3 C N N H O F F F IC50 = 327.0 nM 432.49 CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL4519457 OBDepict Cl O Cl N H O NH 2 CH 3 H ClH IC50 = 400.0 nM 375.68 C[C@H](N)C(=O)NCc1ccc(Oc2cc(Cl)cc(Cl)c2)cc1.Cl Homo sapiens CHEMBL4426987 single protein format
CHEMBL4089823 OBDepict H 3 C N H N NH O F F F IC50 = 434.0 nM 303.33 CNCCN1CC(NCc2cccc(OC(F)(F)F)c2)C1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3589037 OBDepict CH 3 N H N H 3 C N N H O F F F IC50 = 461.0 nM 438.54 CNCCN(C)Cc1cn[nH]c1-c1cc(OCCC2CCCCC2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL4060061 OBDepict H 3 C N H N NH F F F IC50 = 469.0 nM 287.33 CNCCN1CC(NCc2cccc(C(F)(F)F)c2)C1 Homo sapiens CHEMBL3994767 single protein format
CHEMBL3952189 OBDepict CH 3 N H N OH IC50 = 469.0 nM 248.37 CNCCN1CCC(C(O)c2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3907621 OBDepict CH 3 NH N S IC50 = 488.0 nM 250.41 CNCCN1CCC(Sc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3972730 OBDepict CH 3 N H N O O IC50 = 515.0 nM 276.38 CNCCN1CCC(COC(=O)c2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL4469882 OBDepict Cl O Cl NH O NH 2 H 3 C H ClH IC50 = 700.0 nM 375.68 C[C@H](N)C(=O)NCc1ccc(Oc2cccc(Cl)c2Cl)cc1.Cl Homo sapiens CHEMBL4426987 single protein format
CHEMBL4458225 OBDepict O N H NH 2 CH 3 H O ClH IC50 = 800.0 nM 356.85 C[C@H](N)C(=O)NCc1ccc(Oc2cccc3ccccc23)cc1.Cl Homo sapiens CHEMBL4426987 single protein format
CHEMBL3986367 OBDepict CH 3 N H N IC50 = 830.0 nM 246.4 CCNCCN1CCC(Cc2ccccc2)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3961701 OBDepict CH 3 NH N O IC50 = 970.0 nM 248.37 CNCCN1CCC(OCc2ccccc2)CC1 Homo sapiens CHEMBL3859098 cell-based format