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Q96RR4 | KKCC2_HUMAN | Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL416056 OBDepict CH 3 O O HO CH 3 O N H N N H O Ki = 1.8 nM 467.48 COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL940168 single protein format
CHEMBL558642 OBDepict OH O N H N IC50 = 3.0 nM 382.46 O=C(O)c1ccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4875005 OBDepict HO O S N IC50 = 5.0 nM 399.52 O=C(O)c1ccc(-c2csc3ncc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL265470 OBDepict OH O N N O CH 3 O HO IC50 = 10.0 nM 374.35 CC(=O)O.O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21 Homo sapiens CHEMBL1051267 single protein format
CHEMBL4849143 OBDepict OH O N N IC50 = 12.0 nM 394.47 O=C(O)c1ccc(-c2ncnc3ccc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4852523 OBDepict OH O N IC50 = 13.0 nM 317.39 O=C(O)c1ccc(-c2ccnc3ccccc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL1908392 OBDepict H 3 C N N N O CH 3 N H O N H Ki = 15.0 nM 481.6 CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3C(=O)Nc4ccccc43)c3ccccc3)cc2)CC1 Homo sapiens CHEMBL4029822 single protein format
CHEMBL4876404 OBDepict OH O N N IC50 = 21.0 nM 268.32 O=C(O)c1ccc(-c2ccncn2)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4877552 OBDepict HO O N N N IC50 = 21.0 nM 383.45 O=C(O)c1ccc(-c2cnn3ccc(-c4ccccc4)nc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4870467 OBDepict OH O N N N H IC50 = 23.0 nM 383.45 O=C(O)c1ccc(-c2ccnc3[nH]c(-c4ccccc4)nc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4862562 OBDepict OH O N S N IC50 = 24.0 nM 324.4 O=C(O)c1ccc(-c2ncnc3ccsc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4125686 OBDepict OH O N H N IC50 = 26.0 nM 306.37 O=C(O)c1ccc(-c2c[nH]c3ncccc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4853274 OBDepict OH O N N S IC50 = 31.0 nM 324.4 O=C(O)c1ccc(-c2ncnc3sccc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4062168 OBDepict H 3 C O O N H O N H N CH 3 O N N CH 3 Ki = 31.0 nM 539.64 COC(=O)c1ccc2c(c1)/C(=C(/Nc1ccc(N(C)C(=O)CN3CCN(C)CC3)cc1)c1ccccc1)C(=O)N2 Homo sapiens CHEMBL4029822 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 33.6 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328339 single protein format
CHEMBL4851925 OBDepict OH O N N IC50 = 44.0 nM 306.37 O=C(O)c1ccc(-c2cnn3ccccc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4857253 OBDepict OH O N N HN IC50 = 51.0 nM 359.43 O=C(O)c1ccc(-c2ccnc(Nc3ccccc3)n2)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4063500 OBDepict OH N H O HN O NH N N N N O CH 3 H 3 C IC50 = 53.0 nM 535.65 CN(C)C(=O)c1cc2cnc(Nc3ccc(NC(=O)CCCCCCC(=O)NO)cc3)nc2n1C1CCCC1 Homo sapiens CHEMBL4024294 cell-based format
CHEMBL4873692 OBDepict OH O N N H 3 C IC50 = 56.0 nM 320.39 Cn1ccc2c(-c3ccc(C(=O)O)c(C4CCCC4)c3)ccnc21 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4866741 OBDepict HO O O N IC50 = 65.0 nM 383.45 O=C(O)c1ccc(-c2coc3ncc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4089284 OBDepict CH 3 N N N O CH 3 N H O N H O HO Ki = 85.0 nM 525.61 CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3C(=O)Nc4ccc(C(=O)O)cc43)c3ccccc3)cc2)CC1 Homo sapiens CHEMBL4029822 single protein format
CHEMBL4878827 OBDepict OH O N N IC50 = 96.0 nM 318.38 O=C(O)c1ccc(-c2ncnc3ccccc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4857601 OBDepict NH 2 N N O OH IC50 = 108.0 nM 283.33 Nc1nccc(-c2ccc(C(=O)O)c(C3CCCC3)c2)n1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4869147 OBDepict OH O N N H 3 C IC50 = 120.0 nM 396.49 Cn1c(-c2ccccc2)cc2c(-c3ccc(C(=O)O)c(C4CCCC4)c3)ccnc21 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4877634 OBDepict OH O N IC50 = 137.0 nM 393.49 O=C(O)c1ccc(-c2ccnc3ccc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4851892 OBDepict HO O N N IC50 = 145.0 nM 382.46 O=C(O)c1ccc(-c2cnn3ccc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4854650 OBDepict OH O N S N IC50 = 169.0 nM 400.5 O=C(O)c1ccc(-c2ncnc3cc(-c4ccccc4)sc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4863974 OBDepict OH O N N N H IC50 = 193.0 nM 307.35 O=C(O)c1ccc(-c2ccnc3[nH]cnc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL319620 OBDepict OH OH N H HO O OH IC50 = 200.0 nM 275.26 O=C(O)c1cc(NCc2cc(O)ccc2O)ccc1O Homo sapiens CHEMBL940168 single protein format
CHEMBL4857706 OBDepict OH O N N S IC50 = 232.0 nM 400.5 O=C(O)c1ccc(-c2ncnc3sc(-c4ccccc4)cc23)cc1C1CCCC1 Homo sapiens CHEMBL4827571 single protein format
CHEMBL4062218 OBDepict CH 3 N H O O N H CH 3 N N O N H O N H 3 C IC50 = 680.0 nM 512.57 CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 Homo sapiens CHEMBL4031766 assay format