HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q99814 | EPAS1_HUMAN | Endothelial PAS domain-containing protein 1 (EPAS1)

3D structures mapped by conservation among orthologs

[ Domain: "sensor domains" // PAS_11 ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4165091 OBDepict F O Cl F F S HO O O F F IC50 < 5.0 nM 414.74 O=S1(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C(F)F)c2C(O)C1(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4172666 OBDepict F O Cl S H OH O O F F IC50 < 5.0 nM 392.78 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c2c1[C@H](O)CC2)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4169277 OBDepict F O Cl S F F HO O O F F IC50 < 5.0 nM 428.76 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c2c1C(O)C(F)(F)C2)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4165848 OBDepict N O F S F F H HO O O F F IC50 < 5.0 nM 419.33 N#Cc1cc(F)cc(Oc2ccc(S(=O)(=O)C(F)F)c3c2CC(F)(F)[C@H]3O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4176457 OBDepict N O F S F F H HO O O F F F IC50 < 5.0 nM 437.32 N#Cc1cc(F)cc(Oc2ccc(S(=O)(=O)C(F)(F)F)c3c2CC(F)(F)[C@H]3O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4175707 OBDepict F O Cl F F F S OH O O F F IC50 < 5.0 nM 432.73 O=S1(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(C(F)(F)F)c2C(O)C1(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4175320 OBDepict N O F F F S H HO O O F F IC50 < 5.0 nM 405.3 N#Cc1cc(F)cc(Oc2ccc3c(c2C(F)F)[C@@H](O)C(F)(F)S3(=O)=O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4160209 OBDepict F O Cl S HO O O F F IC50 < 5.0 nM 392.78 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c2c1C(O)CC2)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4168682 OBDepict F N H Cl + N O _ O S O O F F F IC50 < 5.0 nM 398.72 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Nc1cc(F)cc(Cl)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4162398 OBDepict N O F S F F H HO O O F IC50 < 5.0 nM 401.34 N#Cc1cc(F)cc(Oc2ccc(S(=O)(=O)CF)c3c2CC(F)(F)[C@H]3O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4165557 OBDepict F O Cl Br S OH O O F F IC50 < 5.0 nM 443.62 O=S1(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(Br)c2C(O)C1(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4453227 OBDepict N O F H F S H OH F F O O CH 3 IC50 = 9.0 nM 401.34 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)C(F)(F)[C@@H]2F Homo sapiens CHEMBL4312562 single protein format
CHEMBL4585668 OBDepict N O F H F S H OH H F O O CH 3 IC50 = 9.0 nM 383.35 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)[C@H](F)[C@@H]2F Homo sapiens CHEMBL4312562 single protein format
CHEMBL4161350 OBDepict N O F S F F OH O O F F IC50 = 10.0 nM 419.33 N#Cc1cc(F)cc(Oc2ccc(S(=O)(=O)C(F)F)c3c2CC(F)(F)C3O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4168513 OBDepict F O F F F S HO O O F F IC50 = 11.0 nM 398.28 O=S1(=O)c2ccc(Oc3cc(F)cc(F)c3)c(C(F)F)c2C(O)C1(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4173075 OBDepict N O F S F F H OH O O CH 3 IC50 = 12.0 nM 383.35 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)C(F)(F)C2 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4163990 OBDepict N O F F F S HO O O F F IC50 = 14.0 nM 405.3 N#Cc1cc(F)cc(Oc2ccc3c(c2C(F)F)C(O)C(F)(F)S3(=O)=O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4176537 OBDepict F N H Cl + N O _ O S O O F F IC50 = 16.0 nM 380.73 O=[N+]([O-])c1cc(S(=O)(=O)C(F)F)ccc1Nc1cc(F)cc(Cl)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4161060 OBDepict F O Cl CH 3 S OH O O F F IC50 = 20.0 nM 378.76 Cc1c(Oc2cc(F)cc(Cl)c2)ccc2c1C(O)C(F)(F)S2(=O)=O Homo sapiens CHEMBL4158376 single protein format
CHEMBL4168978 OBDepict F O Cl Cl S OH O O F F IC50 = 20.0 nM 399.17 O=S1(=O)c2ccc(Oc3cc(F)cc(Cl)c3)c(Cl)c2C(O)C1(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4159016 OBDepict N O F S F F H OH O O CH 3 IC50 = 31.0 nM 397.37 CCS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)C(F)(F)C2 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4168279 OBDepict F O Cl + N O _ O S O O F F F IC50 = 32.0 nM 399.7 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Oc1cc(F)cc(Cl)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597782 OBDepict Br H NH N N H N N F F Br IC50 = 32.0 nM 471.1 Fc1ccc(Br)c(F)c1[C@H]1C[C@@H](c2cccc(Br)c2)Nc2nnnn21 Homo sapiens CHEMBL3599972 assay format
CHEMBL4174407 OBDepict N O S O O F F F F Cl IC50 = 34.0 nM 379.72 N#Cc1cc(S(=O)(=O)C(F)(F)F)ccc1Oc1cc(F)cc(Cl)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4169671 OBDepict N O F S H F H OH O O CH 3 IC50 = 41.0 nM 365.36 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)[C@H](F)C2 Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597786 OBDepict Br H N N H N H N N F Br IC50 = 43.0 nM 453.11 Fc1cc(Br)cc([C@@H]2C[C@H](c3cccc(Br)c3)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format
CHEMBL4164468 OBDepict HO Cl S O O O F F F Cl IC50 = 46.0 nM 401.19 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c(Cl)c1CO)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4167486 OBDepict N O HO S F F O O F Cl IC50 = 49.0 nM 389.74 N#Cc1c(Oc2cc(F)cc(Cl)c2)ccc2c1C(O)C(F)(F)S2(=O)=O Homo sapiens CHEMBL4158376 single protein format
CHEMBL4639113 OBDepict F F S S O O CH 3 F F H HO IC50 < 50.0 nM 366.36 CS(=O)(=O)c1sc(-c2cc(F)cc(F)c2)c2c1[C@H](O)C(F)(F)C2 Homo sapiens CHEMBL4618776 single protein format
CHEMBL4641092 OBDepict N Cl S S O O CH 3 F F H HO IC50 = 50.0 nM 389.83 CS(=O)(=O)c1sc(-c2cc(Cl)cc(C#N)c2)c2c1[C@H](O)C(F)(F)C2 Homo sapiens CHEMBL4618777 cell-based format
CHEMBL4637022 OBDepict N F S S O O CH 3 F F H HO IC50 = 50.0 nM 373.38 CS(=O)(=O)c1sc(-c2ccc(C#N)c(F)c2)c2c1[C@H](O)C(F)(F)C2 Homo sapiens CHEMBL4618776 single protein format
CHEMBL4642490 OBDepict N N Cl S S O O CH 3 H OH F F IC50 < 50.0 nM 404.85 CS(=O)(=O)c1sc(-c2cc(Cl)nc(C#N)c2)c2c1[C@H](O)C(F)(F)CC2 Homo sapiens CHEMBL4618776 single protein format
CHEMBL4636138 OBDepict F N F S S O O CH 3 H OH F F IC50 < 50.0 nM 381.37 CS(=O)(=O)c1sc(-c2cc(F)nc(F)c2)c2c1[C@H](O)C(F)(F)CC2 Homo sapiens CHEMBL4618776 single protein format
CHEMBL4172344 OBDepict HO Br S O O O F F F Cl IC50 = 55.0 nM 445.64 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c(Br)c1CO)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4167415 OBDepict Cl N O S F F H OH O O F F IC50 = 60.0 nM 411.76 O=S(=O)(c1ccc(Oc2cncc(Cl)c2)c2c1[C@H](O)C(F)(F)C2)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597780 OBDepict Br H NH N N H N N Cl Br IC50 = 87.0 nM 469.57 Clc1ccc(Br)cc1[C@H]1C[C@@H](c2cccc(Br)c2)Nc2nnnn21 Homo sapiens CHEMBL3599972 assay format
CHEMBL3597784 OBDepict F Br H N H N N H N N IC50 = 97.0 nM 374.22 Fc1cc(Br)cc([C@@H]2C[C@H](c3ccccc3)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format
CHEMBL3597778 OBDepict Br H N H N N H N N I IC50 = 108.0 nM 482.12 Brc1cccc([C@@H]2C[C@H](c3cccc(I)c3)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format
CHEMBL3597698 OBDepict Br H N H N N H N N Br IC50 = 112.0 nM 435.12 Brc1cccc([C@@H]2C[C@H](c3cccc(Br)c3)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format
CHEMBL4167439 OBDepict N N O F F S HO O O F F IC50 = 140.0 nM 388.3 N#Cc1cncc(Oc2ccc3c(c2C(F)F)C(O)C(F)(F)S3(=O)=O)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4162878 OBDepict F O Cl Cl S O O F F F IC50 = 140.0 nM 389.15 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c(Cl)c1)C(F)(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4437382 OBDepict N O F S H OH O O CH 3 IC50 = 160.0 nM 347.37 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)CC2 Homo sapiens CHEMBL4312562 single protein format
CHEMBL4173593 OBDepict F O Cl Br S O O F F F IC50 = 170.0 nM 433.6 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c(Br)c1)C(F)(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4164152 OBDepict F O Cl Br S O O F F IC50 = 180.0 nM 415.61 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c(Br)c1)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597696 OBDepict Br H NH N N H N N Cl IC50 = 195.0 nM 390.67 Clc1ccccc1[C@H]1C[C@@H](c2cccc(Br)c2)Nc2nnnn21 Homo sapiens CHEMBL3599972 assay format
CHEMBL4467490 OBDepict N O F H F S H OH O O CH 3 IC50 = 210.0 nM 365.36 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)C[C@@H]2F Homo sapiens CHEMBL4312562 single protein format
CHEMBL4167600 OBDepict F O Cl F F S O O F F F IC50 = 220.0 nM 404.71 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c(C(F)F)c1)C(F)(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597690 OBDepict Br H N H N N H N N IC50 = 248.0 nM 356.23 Brc1cccc([C@@H]2C[C@H](c3ccccc3)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format
CHEMBL4175480 OBDepict F N H Cl + N O _ O F F F IC50 = 280.0 nM 334.66 O=[N+]([O-])c1cc(C(F)(F)F)ccc1Nc1cc(F)cc(Cl)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4172030 OBDepict F S O O + N N H O _ O F Cl IC50 = 280.0 nM 362.74 O=[N+]([O-])c1cc(S(=O)(=O)CF)ccc1Nc1cc(F)cc(Cl)c1 Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597694 OBDepict Br H N H N N H N N Br IC50 = 314.0 nM 435.12 Brc1cccc([C@@H]2C[C@H](c3ccccc3Br)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format
CHEMBL4170809 OBDepict N O F S H F H OH O O CH 3 IC50 = 350.0 nM 365.36 CS(=O)(=O)c1ccc(Oc2cc(F)cc(C#N)c2)c2c1[C@H](O)[C@@H](F)C2 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4171869 OBDepict Cl N O F F S OH O O F F IC50 = 350.0 nM 397.73 O=S1(=O)c2ccc(Oc3cncc(Cl)c3)c(C(F)F)c2C(O)C1(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL4164767 OBDepict F O Cl S H OH O O F F IC50 = 460.0 nM 392.78 O=S(=O)(c1ccc(Oc2cc(F)cc(Cl)c2)c2c1[C@@H](O)CC2)C(F)F Homo sapiens CHEMBL4158376 single protein format
CHEMBL2311933 OBDepict F N H Cl + N O _ O N N O IC50 = 490.0 nM 308.66 O=[N+]([O-])c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12 Homo sapiens CHEMBL4158376 single protein format
CHEMBL4169518 OBDepict H 2 N Br S O O O F F F Cl IC50 = 700.0 nM 444.66 NCc1c(S(=O)(=O)C(F)F)ccc(Oc2cc(F)cc(Cl)c2)c1Br Homo sapiens CHEMBL4158376 single protein format
CHEMBL3597692 OBDepict I H N H N N H N N IC50 = 1000.0 nM 403.23 Ic1cccc([C@@H]2C[C@H](c3ccccc3)n3nnnc3N2)c1 Homo sapiens CHEMBL3599972 assay format