HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q99873 | ANM1_HUMAN | Protein arginine N-methyltransferase 1 (PRMT1)

3D structures mapped by conservation among orthologs

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]

download pymol session

[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3589026 OBDepict NH 2 N CH 3 N N H O CH 3 H 3 C IC50 = 4.0 nM 288.4 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3901808 OBDepict NH 2 N CH 3 N H O H 3 C CH 3 IC50 = 4.0 nM 287.41 CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 Homo sapiens CHEMBL3859037 single protein format
CHEMBL3589030 OBDepict NH 2 N CH 3 N N H Cl O CH 3 H 3 C IC50 = 4.0 nM 322.84 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1Cl Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589028 OBDepict NH 2 N CH 3 N N H CH 3 H 3 C IC50 = 5.0 nM 286.42 CC(C)Cc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589031 OBDepict CH 3 HN N CH 3 N N H Cl O CH 3 H 3 C IC50 = 5.0 nM 336.87 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589027 OBDepict CH 3 HN N CH 3 N N H O H 3 C CH 3 IC50 = 7.0 nM 302.42 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589029 OBDepict NH 2 N H 3 C N N H O IC50 = 7.0 nM 322.41 CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589036 OBDepict CH 3 N H N H 3 C N N H O F F F IC50 = 8.0 nM 432.49 CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589913 OBDepict H 3 C NH N H 3 C N N H O CH 3 IC50 = 13.0 nM 288.4 CCOc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589033 OBDepict H 3 C NH N H 3 C N N H O OH CH 3 IC50 = 13.0 nM 332.45 CCC(CO)Oc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589037 OBDepict CH 3 N H N H 3 C N N H O F F F IC50 = 14.0 nM 438.54 CNCCN(C)Cc1cn[nH]c1-c1cc(OCCC2CCCCC2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589032 OBDepict CH 3 HN N CH 3 N N CH 3 Cl O CH 3 H 3 C IC50 = 14.0 nM 350.89 CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589038 OBDepict CH 3 HN N CH 3 N N H O F F F OH CH 3 CH 3 IC50 = 16.0 nM 428.5 CNCCN(C)Cc1cn[nH]c1-c1cc(OC(CO)CC(C)C)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589912 OBDepict H 2 N N CH 3 N N H F IC50 = 18.0 nM 248.31 CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589042 OBDepict H 3 C NH N H 3 C N N H O N O H 3 C CH 3 IC50 = 26.0 nM 407.52 CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589034 OBDepict CH 3 HN N CH 3 N N H O CH 3 H 3 C HO IC50 = 27.0 nM 346.48 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(CO)C(C)C)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL4518534 OBDepict Cl HO H H O H HO H N H OH N N N OH IC50 = 31.0 nM 418.84 OC1CN=C2c3ccn([C@@H]4O[C@H]([C@H](O)c5ccc(Cl)cc5)[C@@H](O)[C@H]4O)c3N=CN21 Homo sapiens CHEMBL4307076 single protein format
CHEMBL3589035 OBDepict H 2 N N H 3 C N N H Cl O F F F CH 3 H 3 C IC50 = 43.0 nM 390.84 CC(C)Oc1c(Cl)cc(-c2c[nH]nc2CN(C)CCN)cc1C(F)(F)F Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3590417 OBDepict CH 3 HN N CH 3 N N H O N H O CH 3 IC50 = 50.0 nM 393.49 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589043 OBDepict H 3 C NH N H 3 C N N H O N O H 3 C CH 3 IC50 = 60.0 nM 407.52 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL4463793 OBDepict NH 2 N CH 3 N H NH O H 2 C IC50 = 100.0 nM 298.39 C=CC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346589 single protein format
CHEMBL3589040 OBDepict H 2 N N CH 3 N N H O N O IC50 = 117.0 nM 373.5 CN(CCN)Cc1c[nH]nc1-c1ccc(OCCCN2CCOCC2)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL3589039 OBDepict CH 3 NH N H 3 C N N H O H H O O IC50 = 119.0 nM 442.6 CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@H](OCCC3CCOCC3)C2)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL4544587 OBDepict NH 2 N CH 3 N H NH O H 3 C IC50 = 170.0 nM 300.41 CCC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346589 single protein format
CHEMBL3589041 OBDepict H 2 N N CH 3 N N H N N O IC50 = 387.0 nM 432.57 CN(CCN)Cc1c[nH]nc1-c1ccc(N2CCN(C(=O)Cc3ccccc3)CC2)cc1 Homo sapiens CHEMBL3591484 cell-based format
CHEMBL418052 OBDepict NH 2 N N N N H O H OH H H HO S NH 2 H O HO Ki = 400.0 nM 384.42 Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL2175615 single protein format
CHEMBL418052 OBDepict NH 2 N N N N H O H OH H H HO S NH 2 H O HO IC50 = 420.0 nM 384.42 Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL3411808 assay format
CHEMBL1214186 OBDepict NH 2 N N N N H O H OH H H HO NH 2 H NH 2 H O HO IC50 < 1000.0 nM 381.39 Nc1ncnc2c1ncn2[C@@H]1O[C@H](C[C@@H](N)CC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O Homo sapiens CHEMBL1115315 single protein format