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Q99884 | SC6A7_HUMAN | Sodium-dependent proline transporter (SLC6A7)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3318586 OBDepict Cl N O N N N IC50 = 18.0 nM 404.9 O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1C2CCC1CN(c1ncccn1)C2 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318579 OBDepict Cl N O H H 3 C N N N IC50 = 21.0 nM 392.89 C[C@H]1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2ccc(Cl)cc2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318574 OBDepict Cl N O CH 3 H 3 C N N N IC50 = 24.0 nM 406.92 CC1CN(c2ncccn2)CC(C)N1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318585 OBDepict Cl N O N N N IC50 = 27.0 nM 404.9 O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CC2CCC(C1)N2c1ncccn1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318563 OBDepict CH 3 S N O N N N IC50 = 34.0 nM 364.47 Cc1csc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)c1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318552 OBDepict O N N N N CH 3 IC50 = 34.0 nM 358.45 Cc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318548 OBDepict Cl N O N N N IC50 = 36.0 nM 378.86 O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318584 OBDepict Cl N O N N N IC50 = 36.0 nM 404.9 O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CC2CN(c3ncccn3)CC2C1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3317462 OBDepict O N N N N Cl IC50 = 52.0 nM 378.86 O=C(c1ccc(-c2ccc(Cl)cc2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318573 OBDepict Cl N O H 3 C CH 3 N N N IC50 = 53.0 nM 406.92 CC1(C)CN(c2ncccn2)CCN1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318580 OBDepict Cl N O H H 3 C N N N IC50 = 57.0 nM 392.89 C[C@@H]1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2ccc(Cl)cc2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318564 OBDepict CH 3 S N O N N N IC50 = 61.0 nM 364.47 Cc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)s1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318549 OBDepict O N N N N F F F IC50 = 71.0 nM 412.42 O=C(c1ccc(-c2cccc(C(F)(F)F)c2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318550 OBDepict O N N N N O F F F IC50 = 73.0 nM 428.41 O=C(c1ccc(-c2cccc(OC(F)(F)F)c2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318554 OBDepict O N N N N F F F IC50 = 76.0 nM 412.42 O=C(c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318576 OBDepict OH N N O N N Cl IC50 = 76.0 nM 408.89 O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CCN(c2ncccn2)CC1CO Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318553 OBDepict CH 3 N O N N N IC50 = 77.0 nM 372.47 CCc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318581 OBDepict Cl N O N N N IC50 = 89.0 nM 392.89 O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CCCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318577 OBDepict HO O N N O N N Cl IC50 = 128.0 nM 422.87 O=C(O)C1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318540 OBDepict O N N N S IC50 = 146.0 nM 349.46 O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nccs2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318562 OBDepict Cl S N O N N N IC50 = 150.0 nM 384.89 O=C(c1ccc(-c2ccc(Cl)s2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL1543754 OBDepict O N N N IC50 = 160.0 nM 343.43 O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2ccccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318551 OBDepict N N O N N N IC50 = 190.0 nM 369.43 N#Cc1cccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)c1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318555 OBDepict N N O N N N IC50 = 190.0 nM 369.43 N#Cc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318556 OBDepict CH 3 O N O N N N IC50 = 230.0 nM 374.44 COc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318557 OBDepict O N N N N F IC50 = 260.0 nM 362.41 O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318543 OBDepict CH 3 N N N N O IC50 = 270.0 nM 358.45 Cc1ccnc(N2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)n1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318567 OBDepict O N N O N N IC50 = 270.0 nM 374.44 O=C(c1ccc(OCc2ccccc2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL1594803 OBDepict O N N N N IC50 = 280.0 nM 344.42 O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318578 OBDepict Cl N O N N O H 3 C CH 3 N N IC50 = 392.0 nM 449.94 CN(C)C(=O)C1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318575 OBDepict O N N CH 3 N N IC50 = 477.0 nM 358.45 CC1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1c1ncccn1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318582 OBDepict Cl N O CH 3 N CH 3 N N IC50 = 586.0 nM 380.88 CN(CCN(C)c1ncccn1)C(=O)c1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318587 OBDepict O N N N N CH 3 IC50 = 653.0 nM 358.45 Cc1ccccc1-c1ccc(C(=O)N2CCN(c3ncccn3)CC2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318572 OBDepict Cl N O N CH 3 CH 3 H 3 C N N IC50 = 700.0 nM 434.97 CC(C)(C)C1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 Homo sapiens CHEMBL3370229 cell-based format
CHEMBL3318569 OBDepict O N N N H N N IC50 = 870.0 nM 373.46 O=C(c1ccc(NCc2ccccc2)cc1)N1CCN(c2ncccn2)CC1 Homo sapiens CHEMBL3370229 cell-based format