Q99986 | VRK1_HUMAN | Serine/threonine-protein kinase VRK1 (VRK1)
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL573107 | IC50 | = | 33.0 | nM | 391.42 | CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C | Homo sapiens | CHEMBL4307651 | cell-based format | |
| CHEMBL4435359 | IC50 | = | 150.0 | nM | 349.28 | Cc1ncc(-c2cc(F)c(O)c(F)c2)cc1-c1cc(F)c(O)c(F)c1 | Homo sapiens | CHEMBL4307651 | cell-based format | |
| CHEMBL4436323 | IC50 | = | 260.0 | nM | 350.27 | Nc1ncc(-c2cc(F)c(O)c(F)c2)cc1-c1cc(F)c(O)c(F)c1 | Homo sapiens | CHEMBL4307651 | cell-based format | |
| CHEMBL4452098 | IC50 | = | 674.0 | nM | 355.37 | Nc1ncc(-c2ccc3ncsc3c2)cc1-c1cc(F)c(O)c(F)c1 | Homo sapiens | CHEMBL4307651 | cell-based format | |
| CHEMBL6291 | IC50 | = | 743.0 | nM | 457.56 | Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL4328650 | single protein format |