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Q9BZL6 | KPCD2_HUMAN | Serine/threonine-protein kinase D2 (PRKD2)

3D structures mapped by conservation among orthologs

[ Domain: "PH domain-like" // PH ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1215000 OBDepict NH 2 O N N NH N HN IC50 = 1.0 nM 374.45 NC(=O)c1cc(-c2ccnc(Nc3ccccc3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215151 OBDepict H N N N N N H N NH IC50 = 1.0 nM 403.53 c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 1.33 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328573 single protein format
CHEMBL1214998 OBDepict NH N N N N N H IC50 = 2.0 nM 388.52 c1cc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2cn1 Homo sapiens CHEMBL1219829 single protein format
CHEMBL1215219 OBDepict H N N N N N H N NH O IC50 = 2.0 nM 405.51 c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCOCC2)n1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215153 OBDepict CH 3 HN H 3 C N N N N N NH H IC50 = 2.0 nM 363.47 CC(C)Nc1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)ccn1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215074 OBDepict CH 3 N N NH N N N O NH 2 HN IC50 = 7.0 nM 378.44 Cn1ccc(Nc2cc(-c3cc(C(N)=O)cc(N4CCNCC4)n3)ccn2)n1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215002 OBDepict CH 3 NH H 3 C N N N O NH 2 HN IC50 = 8.0 nM 340.43 CC(C)Nc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215075 OBDepict NH 2 O N N NH N HN Cl IC50 = 8.0 nM 408.89 NC(=O)c1cc(-c2ccnc(Nc3ccccc3Cl)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1214999 OBDepict NH 2 O N N NH N HN IC50 = 9.0 nM 380.5 NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215001 OBDepict NH 2 O N N NH N HN O IC50 = 9.0 nM 382.47 NC(=O)c1cc(-c2ccnc(NC3CCOCC3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4515390 OBDepict CH 3 NH 2 H N H N N OH N N H 3 C IC50 = 9.0 nM 338.42 CC[C@@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL1214857 OBDepict H 3 C NH CH 3 O N N N N HN O IC50 = 16.0 nM 474.61 CC(C)NC(=O)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 Homo sapiens CHEMBL1219829 single protein format
CHEMBL4644939 OBDepict OH N H N HN IC50 = 17.0 nM 319.41 Oc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL1215220 OBDepict NH 2 O N N H H HN N N H IC50 = 18.0 nM 380.5 NC(=O)c1cc(N[C@@H]2CCNC2)nc(-c2ccnc(NC3CCCCC3)c2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215077 OBDepict H 3 C NH N N N O NH 2 HN IC50 = 31.0 nM 326.4 CCNc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4787572 OBDepict NH 2 N N N N N H HN IC50 = 35.0 nM 347.43 Nc1ncnc2c1c(-c1c[nH]c3ccccc13)nn2CC1CCNCC1 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL1215149 OBDepict N N N NH N NH IC50 = 35.0 nM 356.43 N#Cc1cc(-c2ccnc(Nc3ccccc3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4790321 OBDepict OH CH 3 CH 3 N N N N NH 2 N H IC50 = 43.0 nM 336.4 CC(C)(CO)Cn1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL1683440 OBDepict N N H CH 3 H O N O N H O IC50 = 48.0 nM 430.51 C[C@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 Homo sapiens CHEMBL1686346 single protein format
CHEMBL4576165 OBDepict CH 3 O N N N NH 2 N N N H 3 C IC50 = 48.0 nM 417.52 CCOc1ccc2cc(-c3nn(CC4CCN(C)CC4)c4ncnc(N)c34)ccc2n1 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL1672575 OBDepict CH 3 O N N S S O HN IC50 = 50.0 nM 267.33 COc1ncc2sc3c(c2n1)SCCNC3=O Homo sapiens CHEMBL1681588 single protein format
CHEMBL4776166 OBDepict H 2 N N N N N N H IC50 = 55.0 nM 358.45 Nc1ncnc2c1c(-c1cccc3ccccc13)nn2CC1CCNCC1 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL1215076 OBDepict H 2 N O N N N NH NH IC50 = 59.0 nM 366.47 NC(=O)c1cc(-c2ccnc(NC3CCCC3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215222 OBDepict H 2 N O N N NH H CH 3 N HN IC50 = 60.0 nM 394.52 C[C@@H]1CN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CCN1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215152 OBDepict H N N N N N H N NH IC50 = 62.0 nM 403.53 c1cc(-c2cc(-c3cc[nH]n3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215150 OBDepict N N N HN N N H N N CH 3 IC50 = 68.0 nM 360.43 Cn1ccc(Nc2cc(-c3cc(C#N)cc(N4CCNCC4)n3)ccn2)n1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215361 OBDepict F F N N NH N HN IC50 = 76.0 nM 387.48 FC(F)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215223 OBDepict H 2 N O N N NH H CH 3 N HN IC50 = 86.0 nM 394.52 C[C@H]1CN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CCN1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4779081 OBDepict NH 2 N N N N N H 3 C CH 3 H 3 C H IC50 = 94.0 nM 306.37 CC(C)(C)n1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL1215360 OBDepict F F F N N HN N NH IC50 = 101.0 nM 405.47 FC(F)(F)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4640042 OBDepict NH 2 N H N N H IC50 = 102.0 nM 318.42 Nc1cccc(-c2cc(NC3CCCNC3)c3ccncc3c2)c1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL1215078 OBDepict N N N NH N NH IC50 = 130.0 nM 362.48 N#Cc1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1933288 OBDepict H 3 C N H 3 C N N H N O N H H 3 C O NH IC50 = 139.0 nM 458.57 C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 Homo sapiens CHEMBL1937077 single protein format
CHEMBL4636488 OBDepict H NH N H N IC50 = 144.0 nM 303.41 c1ccc(-c2cc(N[C@H]3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL1215285 OBDepict NH 2 N N O NH 2 N HN IC50 = 168.0 nM 394.52 NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCCC(N)C2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL2205426 OBDepict O O N H N H CH 3 H 3 C CH 3 N N N H N Ki = 175.0 nM 414.47 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O Homo sapiens CHEMBL2209631 single protein format
CHEMBL4645229 OBDepict NH 2 N H N N H IC50 = 187.0 nM 318.42 Nc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL4643470 OBDepict H 2 N HN N IC50 = 202.0 nM 263.34 NCCNc1cc(-c2ccccc2)cc2cnccc12 Homo sapiens CHEMBL4619379 single protein format
CHEMBL1215287 OBDepict NH 2 N N O NH 2 N NH IC50 = 212.0 nM 408.55 NCC1CCN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL1215286 OBDepict CH 3 N N N O NH 2 N NH IC50 = 238.0 nM 394.52 CN1CCN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4646995 OBDepict NH 2 N H N HN IC50 = 246.0 nM 318.42 Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL4641918 OBDepict HN N H N IC50 = 261.0 nM 303.41 c1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL4648006 OBDepict OH N H N N H IC50 = 263.0 nM 319.41 Oc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL1450770 OBDepict HO O NH O IC50 = 280.0 nM 217.22 O=C1NCCCc2c1oc1ccc(O)cc21 Homo sapiens CHEMBL1681588 single protein format
CHEMBL4778331 OBDepict NH 2 N N N N N N H 3 C CH 3 H 3 C H IC50 = 282.0 nM 307.36 CC(C)(C)n1nc(-c2c[nH]c3cccnc23)c2c(N)ncnc21 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL2042135 OBDepict CH 3 N CH 3 S N H 2 N O O NH 2 H 3 C H F F F IC50 = 330.0 nM 490.55 C[C@H](/C=CC(F)(F)F)Oc1cc(-c2cc(-c3cc(CN(C)C)cs3)cnc2N)ccc1C(N)=O Homo sapiens CHEMBL2044163 single protein format
CHEMBL1215288 OBDepict H 2 N O N N NH CH 3 CH 3 N HN IC50 = 427.0 nM 408.55 CC1(C)CN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CCN1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4744428 OBDepict O N H H O N N N N N N CH 3 H 3 C IC50 <= 500.0 nM 433.52 CC(C)n1cnnc1-c1cccc(NC(=O)[C@H]2CN(c3ccc(C4CC4)nc3)CCO2)n1 Homo sapiens CHEMBL4727566 assay format
CHEMBL1215221 OBDepict NH 2 O N N H H HN N N H IC50 = 540.0 nM 380.5 NC(=O)c1cc(N[C@H]2CCNC2)nc(-c2ccnc(NC3CCCCC3)c2)c1 Homo sapiens CHEMBL1219873 single protein format
CHEMBL4642061 OBDepict CH 3 NH O N H N N H IC50 = 762.0 nM 360.46 CC(=O)Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 Homo sapiens CHEMBL4619379 single protein format
CHEMBL573578 OBDepict H 2 N N N N N CH 3 H 3 C CH 3 IC50 = 786.0 nM 331.42 CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21 Homo sapiens CHEMBL4774310 cell-based format
CHEMBL378627 OBDepict H 3 C O S O O O CH 3 N H O H 3 C N NH 2 O N H 3 C CH 3 Ki = 950.0 nM 448.5 COc1cc(S(C)(=O)=O)c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 Homo sapiens CHEMBL863189 single protein format
CHEMBL590109 OBDepict H 2 N N N N NH 2 N N S H IC50 = 950.0 nM 425.52 NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 Homo sapiens CHEMBL1072677 single protein format