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Q9C0B1 | FTO_HUMAN | Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)

3D structures mapped by conservation among orthologs

[ Domain: "Double-stranded beta-helix" // FTO_NTD ]

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[ Domain: "Alpha-ketoglutarate-dependent dioxygenase FTO helical domain" // FTO_CTD ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4572939 OBDepict Cl N H Cl H 3 C N CH 3 O O HO IC50 = 60.0 nM 377.23 Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(=O)O)c(Cl)c1 Homo sapiens CHEMBL4418244 single protein format
CHEMBL4448030 OBDepict N N N OH + N HO O _ O IC50 <= 250.0 nM 284.23 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1cnccn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4563060 OBDepict N N N OH + N O OH HO O _ O IC50 <= 300.0 nM 328.24 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1cnc(C(=O)O)cn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4532629 OBDepict H N N N N NH Cl Cl CH 3 N H 3 C O IC50 = 400.0 nM 401.26 Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2-c2nn[nH]n2)c(Cl)c1 Homo sapiens CHEMBL4418244 single protein format
CHEMBL4527360 OBDepict N N N OH + N OH O _ O IC50 <= 500.0 nM 284.23 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1ccncn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4567049 OBDepict CH 3 N O H 3 C NH 2 N OH + N HO O _ O IC50 <= 500.0 nM 320.31 CCN(CC)C(=O)/C(C#N)=C(N)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4435468 OBDepict N OH N H O N S HO + N HO O _ O IC50 <= 500.0 nM 348.3 N#C/C(C(=O)Nc1nccs1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4467308 OBDepict N OH N N HO + N HO O _ O IC50 <= 500.0 nM 300.23 N#C/C(=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccncn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4529597 OBDepict N OH N N HO + N HO O _ O IC50 <= 500.0 nM 300.23 N#C/C(=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1)c1cnccn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4461072 OBDepict CH 3 N O H 3 C OH N OH + N HO O _ O IC50 <= 500.0 nM 321.29 CCN(CC)C(=O)/C(C#N)=C(O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4563024 OBDepict OH HO Cl Cl N H O OH IC50 = 700.0 nM 390.22 O=C(O)c1ccccc1Nc1c(Cl)cc(-c2cc(O)cc(O)c2)cc1Cl Homo sapiens CHEMBL4418244 single protein format
CHEMBL4590326 OBDepict N H 2 N N O OH + N OH O _ O IC50 <= 750.0 nM 332.32 N#C/C(C(=O)N1CCCCC1)=C(/N)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4458750 OBDepict N HO N O OH + N OH O _ O IC50 <= 750.0 nM 305.25 N#C/C(C(=O)N1CCC1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4463923 OBDepict N OH N N HO + N HO O _ O O OH IC50 <= 750.0 nM 344.24 N#C/C(=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1)c1cnc(C(=O)O)cn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4569935 OBDepict N OH N HO + N HO O _ O IC50 <= 750.0 nM 299.24 N#C/C(=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4474943 OBDepict N HN O N S OH + N OH O _ O IC50 = 1000.0 nM 332.3 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)Nc1nccs1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4445539 OBDepict N S N O OH OH + N HO O _ O IC50 < 1000.0 nM 333.28 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1nc(C(=O)O)cs1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4547872 OBDepict N N OH + N OH O _ O IC50 < 1000.0 nM 283.24 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1cccnc1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4541729 OBDepict N N CH 3 OH + N HO O _ O IC50 < 1000.0 nM 297.27 Cc1ccc(/C(C#N)=C/c2cc(O)c(O)c([N+](=O)[O-])c2)nc1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4474437 OBDepict N N N OH + N OH O _ O IC50 < 1000.0 nM 284.23 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1cccnn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4447107 OBDepict N N + N _ O OH + N OH O _ O IC50 < 1000.0 nM 300.23 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1c[n+]([O-])ccn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4564612 OBDepict OH HN O N OH + N HO O _ O IC50 = 1000.0 nM 265.18 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)NO Homo sapiens CHEMBL4418739 single protein format
CHEMBL4558186 OBDepict CH 3 N H O H 2 N N OH + N OH O _ O IC50 = 1000.0 nM 292.25 CCNC(=O)/C(C#N)=C(N)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4522359 OBDepict N O OH N S HO + N HO O _ O IC50 = 1000.0 nM 333.28 N#C/C(C(=O)c1cscn1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4592513 OBDepict N HO N O OH + N OH O _ O IC50 = 1000.0 nM 333.3 N#C/C(C(=O)N1CCCCC1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4453979 OBDepict N OH N S OH + N OH O _ O IC50 = 1000.0 nM 305.27 N#C/C(=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1)c1nccs1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4464343 OBDepict N N O HO + N HO O _ O IC50 <= 1000.0 nM 289.25 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)N1CCC1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4474241 OBDepict N OH N N O + N CH 3 OH O _ O IC50 = 1000.0 nM 314.26 COc1cc(/C(O)=C(C#N)c2cnccn2)cc([N+](=O)[O-])c1O Homo sapiens CHEMBL4418739 single protein format
CHEMBL4524626 OBDepict N N S N OH + N HO O _ O IC50 < 1000.0 nM 290.26 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1ncns1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4557292 OBDepict N N H O H O OH OH HO + N OH O _ O IC50 = 1000.0 nM 337.24 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)N[C@@H](CO)C(=O)O Homo sapiens CHEMBL4418739 single protein format
CHEMBL4435048 OBDepict N N O O OH + N OH O _ O IC50 < 1000.0 nM 319.27 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)N1CCCOC1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4459873 OBDepict N N H O O HO + N OH O _ O IC50 < 1000.0 nM 305.25 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)NC1COC1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4570495 OBDepict N NH O OH + N HO O _ O IC50 = 1000.0 nM 325.28 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)Nc1ccccc1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL469803 OBDepict N NH O OH + N Cl HO O _ O IC50 = 1000.0 nM 359.73 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)Nc1cccc(Cl)c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL525388 OBDepict N N O OH + N OH O _ O IC50 = 1000.0 nM 317.3 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)N1CCCCC1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4476652 OBDepict N N O H O HO OH + N OH O _ O IC50 = 1000.0 nM 347.28 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)N1CCC[C@H]1C(=O)O Homo sapiens CHEMBL4418739 single protein format
CHEMBL4531642 OBDepict N N S OH + N HO O _ O IC50 = 1000.0 nM 289.27 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1nccs1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4476272 OBDepict N N OH + N OH O _ O IC50 = 1000.0 nM 283.24 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4441097 OBDepict N N OH + N OH O _ O IC50 = 1000.0 nM 283.24 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1ccncc1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4456378 OBDepict N HN O O OH HO + N OH O _ O IC50 < 1000.0 nM 307.22 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)NCC(=O)O Homo sapiens CHEMBL4418739 single protein format
CHEMBL4440198 OBDepict N N N OH + N OH O _ O IC50 = 1000.0 nM 284.23 N#C/C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1cncnc1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4461985 OBDepict N OH N H O N S HO + N N HO O _ O IC50 < 1000.0 nM 349.28 N#C/C(C(=O)Nc1ncns1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4462025 OBDepict N OH NH O OH + N N OH O _ O N IC50 < 1000.0 nM 357.28 N#C/C(C(=O)NCc1ccncn1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4555895 OBDepict N HO N H O N OH + N N OH O _ O IC50 < 1000.0 nM 343.25 N#C/C(C(=O)Nc1cnccn1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4572182 OBDepict N NH O H 3 C O OH OH + N HO O _ O IC50 = 1000.0 nM 321.25 CC(NC(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1)C(=O)O Homo sapiens CHEMBL4418739 single protein format
CHEMBL4442734 OBDepict N HO N H O OH + N OH O _ O IC50 < 1000.0 nM 305.25 N#C/C(C(=O)NC1CC1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4463600 OBDepict N HO N O O OH + N OH O _ O IC50 < 1000.0 nM 335.27 N#C/C(C(=O)N1CCCOC1)=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4570960 OBDepict N NH 2 N N HO + N HO O _ O O OH IC50 < 1000.0 nM 343.26 N#C/C(=C(/N)c1cc(O)c(O)c([N+](=O)[O-])c1)c1cnc(C(=O)O)cn1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4438114 OBDepict CH 3 N O CH 3 N H N CH 3 OH + N OH O _ O IC50 = 1000.0 nM 334.33 CCN(CC)C(=O)/C(C#N)=C(NC)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format
CHEMBL4552801 OBDepict CH 3 N H O HO N OH + N OH O _ O IC50 < 1000.0 nM 293.24 CCNC(=O)/C(C#N)=C(O)c1cc(O)c(O)c([N+](=O)[O-])c1 Homo sapiens CHEMBL4418739 single protein format