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Q9H0K1 | SIK2_HUMAN | Serine/threonine-protein kinase SIK2 (SIK2)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 0.37 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328604 single protein format
CHEMBL4859969 OBDepict HO N N N N N H CH 3 N S N H O Cl Cl S IC50 = 2.0 nM 514.46 Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl IC50 = 3.0 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL3780091 OBDepict O N H NH N N H H H H 2 N IC50 = 4.0 nM 323.4 N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 Homo sapiens CHEMBL3784254 single protein format
CHEMBL3326006 OBDepict CH 3 N H N N N H H OH N N H 3 C IC50 = 5.75 nM 476.67 CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL3363360 single protein format
CHEMBL3770443 OBDepict CH 3 HN N N N O H O O Cl H H 2 N N CH 3 IC50 = 9.0 nM 492.97 CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 Homo sapiens CHEMBL3772533 single protein format
CHEMBL4847716 OBDepict OH N N N N N H CH 3 N S N H O CH 3 S Cl IC50 = 10.0 nM 494.05 Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)csc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4875238 OBDepict H 3 C N N N N N H CH 3 N S N H O Cl S H 3 C IC50 = 10.0 nM 464.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(C)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4867844 OBDepict OH N N N N N H CH 3 N S N H O Cl S CH 3 IC50 = 11.7 nM 494.05 Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4865466 OBDepict CH 3 N O N N N NH H 3 C N S N H O Cl S CH 3 IC50 = 25.0 nM 492.03 CC(=O)N1CCN(c2cc(Nc3ncc(C(=O)Nc4c(C)csc4Cl)s3)nc(C)n2)CC1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4855726 OBDepict OH N N HN N N N H CH 3 N S NH O Cl H 3 C N IC50 = 60.0 nM 504.02 Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(NN2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4857583 OBDepict HO N N N N N H CH 3 N S N H O H 3 C H 3 C N IC50 = 119.0 nM 468.59 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cncc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4869199 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl N IC50 = 130.0 nM 489.01 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cncc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4851745 OBDepict CH 3 N N N N N H CH 3 N S N H O Cl CH 3 N IC50 = 138.0 nM 458.98 Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(N2CCN(C)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4850733 OBDepict HO N N N N N H CH 3 N S N H O H 3 C N H 3 C O IC50 = 232.0 nM 458.55 Cc1nc(Nc2ncc(C(=O)Nc3c(C)noc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4517408 OBDepict CH 3 O O CH 3 O H 3 C N CH 3 N HN IC50 = 336.0 nM 419.53 COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC Homo sapiens CHEMBL4626198 single protein format
CHEMBL4872654 OBDepict OH N N N N N H CH 3 N S N H O CH 3 N IC50 = 385.0 nM 454.56 Cc1nc(Nc2ncc(C(=O)Nc3cccnc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4865214 OBDepict OH N N N N N H CH 3 N S N H O N CH 3 IC50 = 427.0 nM 454.56 Cc1nc(Nc2ncc(C(=O)Nc3ncccc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4857318 OBDepict OH HN N N N H CH 3 N S NH O Cl CH 3 N IC50 = 470.0 nM 419.9 Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)n1 Homo sapiens CHEMBL4807588 single protein format
CHEMBL4878274 OBDepict HO N N N N N H CH 3 N S N H O H 3 C H 3 C N IC50 = 641.0 nM 468.59 Cc1nc(Nc2ncc(C(=O)Nc3c(C)ccnc3C)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807588 single protein format