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Q9H237 | PORCN_HUMAN | Protein-serine O-palmitoleoyltransferase porcupine (PORCN)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2139947 OBDepict O N H N N CH 3 IC50 = 0.074 nM 379.46 Cc1cc(-c2ccc(CC(=O)Nc3ccc(-c4cccnc4)cc3)cc2)ccn1 Homo sapiens CHEMBL3635400 cell-based format
CHEMBL3623895 OBDepict CH 3 N O CH 3 N H O N N N IC50 = 0.11 nM 411.47 Cc1cc(-c2ccc(OC(C)C(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623894 OBDepict O HN N N N N CH 3 IC50 = 0.19 nM 395.47 Cc1cc(-c2ccc(CCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623875 OBDepict O N H O N N N N CH 3 IC50 = 0.23 nM 383.41 Cc1cc(-c2ccc(OC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3188386 OBDepict O N H N N CH 3 N N N CH 3 IC50 = 0.4 nM 396.45 Cc1cc(-c2ncc(CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2C)ccn1 Homo sapiens CHEMBL3635400 cell-based format
CHEMBL4080208 OBDepict O N H N N O N N H 3 C CH 3 O S IC50 = 0.4 nM 395.44 Cn1c(=O)c2c(ncn2CC(=O)Nc2ccc(-c3ccsc3)cc2)n(C)c1=O Homo sapiens CHEMBL4040031 cell-based format
CHEMBL3633801 OBDepict H 3 C N O N O CH 3 N N CH 3 H N H O S IC50 = 0.5 nM 409.47 C[C@@H](C(=O)Nc1ccc(-c2ccsc2)cc1)n1cnc2c1c(=O)n(C)c(=O)n2C Homo sapiens CHEMBL3635401 cell-based format
CHEMBL3623893 OBDepict O HN S N N N N CH 3 IC50 = 0.53 nM 413.51 Cc1cc(-c2ccc(SCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623896 OBDepict O N H N N CH 3 N N N CH 3 IC50 = 0.57 nM 396.45 Cc1ccc(-c2ncc(CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2C)cn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623892 OBDepict O NH N CH 3 N N N N CH 3 IC50 = 0.67 nM 410.48 Cc1cc(-c2ccc(N(C)CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623891 OBDepict O HN N H N N N N CH 3 IC50 = 0.96 nM 396.45 Cc1cc(-c2ccc(NCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL4088716 OBDepict O N H NH H 3 C H N N N N CH 3 N IC50 = 1.0 nM 399.46 C[C@H](Nc1ccc(-c2ccnn2C)nc1)C(=O)Nc1ccc(-c2cccnc2)cn1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4080842 OBDepict O N H NH H 3 C H N N N CH 3 N IC50 = 1.0 nM 398.47 C[C@H](Nc1ccc(-c2ccnn2C)nc1)C(=O)Nc1ccc(-c2ccccc2)cn1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4096728 OBDepict O NH N N O N O CH 3 IC50 = 1.0 nM 376.42 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccc3)cn1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4080021 OBDepict O NH N N N O N O CH 3 IC50 = 1.0 nM 377.4 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccc3)nn1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4070649 OBDepict O HN O N CH 3 N IC50 = 2.0 nM 383.45 Cc1nccn1-c1ccc(OCC(=O)Nc2ccc(-c3ccccc3)cc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL3623874 OBDepict O O NH N N CH 3 IC50 = 2.2 nM 381.44 Cc1cc(-c2ccc(OC(=O)Nc3ccc(-c4cccnc4)cc3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623887 OBDepict N O N H O N N N IC50 = 2.7 nM 381.4 N#Cc1ccc2cc(OCC(=O)Nc3ccc(-c4cnccn4)cn3)ccc2c1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3633802 OBDepict O N H N N N N O N N H 3 C CH 3 O IC50 = 2.9 nM 391.39 Cn1c(=O)c2c(ncn2CC(=O)Nc2ccc(-c3ccccc3)nn2)n(C)c1=O Homo sapiens CHEMBL3635401 cell-based format
CHEMBL4099279 OBDepict O HN O N CH 3 N IC50 = 4.0 nM 383.45 Cn1nccc1-c1ccc(OCC(=O)Nc2ccc(-c3ccccc3)cc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL3623873 OBDepict O O NH N CH 3 IC50 = 5.0 nM 380.45 Cc1cc(-c2ccc(OC(=O)Nc3ccc(-c4ccccc4)cc3)cc2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL4084739 OBDepict O N H HN CH 3 H N N N IC50 = 5.0 nM 383.45 C[C@H](Nc1ccc(-n2ccnc2)cc1)C(=O)Nc1ccc(-c2ccccc2)cn1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL3633804 OBDepict O N H H N N N N O N N CH 3 CH 3 O IC50 = 5.0 nM 431.46 Cn1c(=O)c2c(nc3n2[C@H](CC(=O)Nc2ccc(-c4ccccc4)nn2)CC3)n(C)c1=O Homo sapiens CHEMBL3635405 cell-based format
CHEMBL4069295 OBDepict O NH N N O N O CH 3 IC50 = 6.0 nM 376.42 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccc3)nc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4089128 OBDepict O N H O CH 3 H N N IC50 = 7.0 nM 383.45 C[C@H](Oc1ccc(-n2ccnc2)cc1)C(=O)Nc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4104447 OBDepict O NH N O N O CH 3 N IC50 = 8.0 nM 376.42 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3cccnc3)cc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4540197 OBDepict CH 3 N S N N HN O N N S O CH 3 IC50 = 8.0 nM 440.55 CCCn1c(SCC(=O)Nc2nc3ccc(OC)cc3s2)nnc1-c1ccncc1 Homo sapiens CHEMBL4427410 single protein format
CHEMBL4066589 OBDepict O NH N N N O N O CH 3 N F IC50 = 9.0 nM 396.38 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3cncc(F)c3)nn1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4098880 OBDepict O N H NH H 3 C H N N N N CH 3 N IC50 = 10.0 nM 399.46 C[C@H](Nc1ccc(-c2ccnn2C)nc1)C(=O)Nc1ccc(-c2cccnc2)nc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4095609 OBDepict O N H N N N O N O N F IC50 = 11.0 nM 422.42 O=C(CN1CCCC2=C1C(=O)N(C1CC1)C2=O)Nc1ccc(-c2cncc(F)c2)nn1 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4096529 OBDepict O NH N N O N O CH 3 N IC50 = 11.0 nM 377.4 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3cccnc3)nc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4066796 OBDepict O NH N O N O CH 3 IC50 = 12.0 nM 375.43 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccc3)cc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4103356 OBDepict O N H N N N O N O N CH 3 IC50 = 12.0 nM 418.46 Cc1ccc(-c2ccc(NC(=O)CN3CCCC4=C3C(=O)N(C3CC3)C4=O)nn2)cn1 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4087906 OBDepict O N H N N N O N O N IC50 = 12.0 nM 404.43 O=C(CN1CCCC2=C1C(=O)N(C1CC1)C2=O)Nc1ccc(-c2cccnc2)nn1 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4094309 OBDepict O NH N O N O CH 3 N S IC50 = 15.0 nM 382.45 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3nccs3)cc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4097104 OBDepict O N H O N N IC50 = 15.0 nM 369.42 O=C(COc1ccc(-n2ccnc2)cc1)Nc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4061069 OBDepict O NH O N CH 3 O N S IC50 = 15.0 nM 377.43 CN1C(=O)c2cccc(CC(=O)Nc3ccc(-c4nccs4)cc3)c2C1=O Homo sapiens CHEMBL4040031 cell-based format
CHEMBL3623889 OBDepict O N H O N N N N O CH 3 IC50 = 24.0 nM 403.44 CC(=O)N1CCc2ccc(OCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2C1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL4066798 OBDepict O N H N N O N N H 3 C CH 3 O N S IC50 = 24.0 nM 396.43 Cn1c(=O)c2c(ncn2CC(=O)Nc2ccc(-c3nccs3)cc2)n(C)c1=O Homo sapiens CHEMBL4040031 cell-based format
CHEMBL3633800 OBDepict CH 3 O N F S N O S N H O N S CH 3 IC50 = 27.0 nM 514.63 COc1cc(F)ccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2c(c1=O)SCC2 Homo sapiens CHEMBL3635400 cell-based format
CHEMBL4075204 OBDepict O NH N N N O N O CH 3 N H 3 C IC50 = 29.0 nM 392.42 Cc1ccc(-c2ccc(NC(=O)CN3CCCC4=C3C(=O)N(C)C4=O)nn2)cn1 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4104257 OBDepict O NH N N N O N O CH 3 N IC50 = 29.0 nM 378.39 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3cccnc3)nn1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4081262 OBDepict O N H NH N N IC50 = 30.0 nM 368.44 O=C(CNc1ccc(-n2ccnc2)cc1)Nc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL3623879 OBDepict O N H O N N N N IC50 = 30.0 nM 357.37 O=C(COc1ccc2ccncc2c1)Nc1ccc(-c2cnccn2)cn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623878 OBDepict O N H S N N N N CH 3 IC50 = 40.0 nM 413.51 Cc1cc(-c2cccc(SCC(=O)Nc3ccc(-c4cnccn4)cn3)c2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL4096832 OBDepict O HN H N N N IC50 = 40.0 nM 408.51 O=C(Nc1ccc(-c2ccccc2)cc1)[C@@H]1CCCN1c1ccc(-n2ccnc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4063419 OBDepict O N H O O N IC50 = 42.0 nM 370.41 O=C(COc1ccc(-c2cnco2)cc1)Nc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4102043 OBDepict O N H N N O N N CH 3 H 3 C O N S IC50 = 42.0 nM 422.47 Cn1c(=O)c2c(nc3n2C(C(=O)Nc2ccc(-c4nccs4)cc2)CC3)n(C)c1=O Homo sapiens CHEMBL4040031 cell-based format
CHEMBL1257063 OBDepict CH 3 O N N O N H O N H O N S O CH 3 IC50 = 60.0 nM 515.55 COc1ccc(-n2nc(C(=O)NCC(=O)Nc3nc4ccc(OC)cc4s3)c3ccccc3c2=O)cc1 Homo sapiens CHEMBL3635400 cell-based format
CHEMBL4088085 OBDepict CH 3 O N N O N H N H O N S O CH 3 IC50 = 60.0 nM 501.57 COc1ccc(-n2nc(CNCC(=O)Nc3nc4ccc(OC)cc4s3)c3ccccc3c2=O)cc1 Homo sapiens CHEMBL4040030 single protein format
CHEMBL4086549 OBDepict O NH N O N O CH 3 N IC50 = 67.0 nM 376.42 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccn3)cc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4078705 OBDepict O NH N O N O CH 3 N IC50 = 72.0 nM 376.42 CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccncc3)cc1)CCC2 Homo sapiens CHEMBL4040031 cell-based format
CHEMBL4060944 OBDepict O N H O CH 3 H N N IC50 = 130.0 nM 383.45 C[C@@H](Oc1ccc(-n2ccnc2)cc1)C(=O)Nc1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL1257064 OBDepict O N H S N S N N O CH 3 S IC50 = 157.0 nM 466.61 Cc1ccc2nc(NC(=O)CSc3nc4c(c(=O)n3-c3ccccc3)SCC4)sc2c1 Homo sapiens CHEMBL4189235 cell-based format
CHEMBL3623877 OBDepict O N H NH N N N N CH 3 IC50 = 164.0 nM 396.45 Cc1cc(-c2cccc(NCC(=O)Nc3ccc(-c4cnccn4)cn3)c2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623876 OBDepict O N H O N N N N CH 3 IC50 = 188.0 nM 397.44 Cc1cc(-c2cccc(OCC(=O)Nc3ccc(-c4cnccn4)cn3)c2)ccn1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623890 OBDepict O HN O N N N N N O CH 3 IC50 = 483.0 nM 432.48 CC(=O)N1CCN(c2ccc(OCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)CC1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL3623888 OBDepict N O N H O N N N IC50 = 485.0 nM 331.34 N#Cc1ccc(OCC(=O)Nc2ccc(-c3cnccn3)cn2)cc1 Homo sapiens CHEMBL3626166 cell-based format
CHEMBL4102661 OBDepict O N H HN CH 3 H N N N IC50 = 689.0 nM 383.45 C[C@@H](Nc1ccc(-n2ccnc2)cc1)C(=O)Nc1ccc(-c2ccccc2)cn1 Homo sapiens CHEMBL4000296 cell-based format
CHEMBL4204681 OBDepict CH 3 O N S N O S N H O N S F F F IC50 = 710.0 nM 564.64 COc1ccc(Cn2c(SCC(=O)Nc3nc4ccc(C(F)(F)F)cc4s3)nc3c(c2=O)SCC3)cc1 Homo sapiens CHEMBL4189235 cell-based format