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Q9H2G2 | SLK_HUMAN | STE20-like serine/threonine-protein kinase (SLK)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4875188 OBDepict H 3 C O O N H HN O N Ki = 3.7 nM 319.32 COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4878325 OBDepict N NH O N H O O CH 3 Br Ki = 3.9 nM 398.22 COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4877889 OBDepict H 3 C O O N H N H O Ki = 6.0 nM 344.37 COc1ccccc1C1=C(Nc2cccc3ccccc23)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL3326006 OBDepict CH 3 N H N N N H H OH N N H 3 C IC50 = 6.14 nM 476.67 CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL3363361 single protein format
CHEMBL156277 OBDepict CH 3 O O N H NH O Cl Ki = 6.6 nM 328.76 COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL156277 OBDepict CH 3 O O N H NH O Cl IC50 = 7.8 nM 328.76 COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839429 single protein format
CHEMBL4875188 OBDepict H 3 C O O N H HN O N IC50 = 8.2 nM 319.32 COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839429 single protein format
CHEMBL157089 OBDepict H 3 C O O N H HN O Cl OH Ki = 8.5 nM 344.75 COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4856751 OBDepict CH 3 O Br O N H NH O N Ki = 9.7 nM 398.22 COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4855513 OBDepict CH 3 O O N H NH O F Ki = 13.0 nM 312.3 COc1ccccc1C1=C(Nc2cccc(F)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 14.6 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328606 single protein format
CHEMBL4869745 OBDepict H 3 C O O N H HN O O O Ki = 15.0 nM 338.32 COc1ccccc1C1=C(Nc2ccc3c(c2)OCO3)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4867952 OBDepict H 3 C O HN O N H HN O O CH 3 CH 3 N Ki = 17.0 nM 404.43 COc1cc(NC(=O)C(C)C)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4868821 OBDepict CH 3 O O N H NH O N Ki = 17.0 nM 345.36 COc1ccccc1C1=C(Nc2ccc3ncccc3c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4857159 OBDepict CH 3 O O N H NH O S CH 3 Ki = 17.0 nM 340.4 COc1ccccc1C1=C(Nc2cccc(SC)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL157141 OBDepict O N H NH O Cl Cl HO Ki = 17.0 nM 349.17 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)c(Cl)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL349540 OBDepict CH 3 O O N H NH O S H 3 C Ki = 21.0 nM 340.4 COc1ccccc1C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4852101 OBDepict CH 3 O HN O N H O O H 3 C Ki = 22.0 nM 324.34 COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4851482 OBDepict H 3 C O O N H HN O Ki = 25.0 nM 370.41 COc1ccccc1C1=C(Nc2ccc(-c3ccccc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL156506 OBDepict Cl NH O N H O Cl Ki = 28.0 nM 333.17 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(Cl)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4847820 OBDepict CH 3 O HN O N H O O H 3 C Ki = 29.0 nM 324.34 COc1cccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4877101 OBDepict N HN O N H O Ki = 29.0 nM 339.35 N#Cc1cccc(NC2=C(c3cccc4ccccc34)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4845800 OBDepict N HN O N H O O CH 3 Cl N Cl Ki = 30.0 nM 465.3 COc1cc(-c2ccc(Cl)nc2Cl)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4858023 OBDepict CH 3 S HN O N H O Cl Ki = 33.0 nM 344.82 CSc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL160338 OBDepict H 3 C O O N H HN O OH Ki = 35.0 nM 310.31 COc1ccccc1C1=C(Nc2ccc(O)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4876254 OBDepict H 3 C O O N H N H O O Ki = 37.0 nM 398.42 COc1ccccc1C1=C(Nc2ccc(C(=O)c3ccccc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL347702 OBDepict OH HN O N H O Cl Ki = 40.0 nM 314.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)cc1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4869281 OBDepict CH 3 O O N H HN O N Ki = 40.0 nM 395.42 COc1ccc(-c2ccccc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4848202 OBDepict N HN O N H O Cl Ki = 41.0 nM 323.74 N#Cc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4863077 OBDepict H 3 C O O N H HN O S Ki = 43.0 nM 376.44 COc1ccccc1C1=C(Nc2ccc(-c3ccsc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4878748 OBDepict F NH O N H O Cl Ki = 44.0 nM 316.72 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(F)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4854271 OBDepict H 3 C O O N H HN O N O Ki = 47.0 nM 379.42 COc1ccccc1C1=C(Nc2ccc(N3CCOCC3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4283353 OBDepict CH 3 N H H 3 C H N N N H H OH N N H 3 C IC50 = 47.0 nM 504.72 CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276360 assay format
CHEMBL160937 OBDepict HO NH O N H O Cl Ki = 56.0 nM 314.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL156563 OBDepict CH 3 S HN O N H O Cl Ki = 59.0 nM 344.82 CSc1ccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)cc1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL160231 OBDepict CH 3 O O N H NH O HO Ki = 60.0 nM 310.31 COc1ccccc1C1=C(Nc2cccc(O)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4847807 OBDepict CH 3 O O N H NH O F F F Ki = 61.0 nM 362.31 COc1ccccc1C1=C(Nc2cccc(C(F)(F)F)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL347647 OBDepict O N H NH O Cl Ki = 69.0 nM 298.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccccc1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4851803 OBDepict O N H HN O Cl F F F OH Ki = 76.0 nM 382.73 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1ccc(O)c(Cl)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4848740 OBDepict CH 3 O O NH H 3 C O N H O O CH 3 Ki = 86.0 nM 354.36 COc1cc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc(OC)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4877795 OBDepict CH 3 O O NH N H O S O O CH 3 Ki = 95.0 nM 372.4 COc1ccccc1C1=C(Nc2cccc(S(C)(=O)=O)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4860051 OBDepict CH 3 S HN O N H O F F F Ki = 100.0 nM 378.38 CSc1cccc(NC2=C(c3ccccc3C(F)(F)F)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL345800 OBDepict CH 3 O O N H NH O Cl Cl HO Ki = 110.0 nM 379.2 COc1ccccc1C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4855633 OBDepict H 3 C O O N H N H O S Ki = 110.0 nM 376.44 COc1ccccc1C1=C(Nc2cccc(-c3ccsc3)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4873631 OBDepict H 3 C O O N H N H O N H Ki = 120.0 nM 385.42 COc1ccccc1C1=C(Nc2ccc(Nc3ccccc3)cc2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL346829 OBDepict CH 3 O O N H NH O Cl Ki = 120.0 nM 328.76 COc1cccc(C2=C(Nc3cccc(Cl)c3)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4848852 OBDepict Cl HN O N H O F F F Ki = 130.0 nM 366.73 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(Cl)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4859423 OBDepict H 3 C O O N H HN O Cl O Ki = 170.0 nM 434.88 COc1ccccc1C1=C(Nc2ccc(OCc3ccccc3)c(Cl)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4875006 OBDepict H 3 C O O N H HN S O N Ki = 180.0 nM 401.45 COc1cc(-c2ccsc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4855321 OBDepict O N H NH O Cl F F F Ki = 200.0 nM 366.73 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(C(F)(F)F)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4876004 OBDepict CH 3 O O HN CH 3 O N H O O H 3 C Ki = 210.0 nM 354.36 COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc1OC Homo sapiens CHEMBL4839426 single protein format
CHEMBL4852451 OBDepict CH 3 O O N H NH N O N Ki = 240.0 nM 396.41 COc1cc(-c2cccnc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4875281 OBDepict F HN O N H O F F F Ki = 240.0 nM 350.27 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(F)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4876241 OBDepict OH HN O N H O F F F Ki = 280.0 nM 348.28 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1ccc(O)cc1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL157258 OBDepict O N H NH O Cl Cl Cl HO Ki = 300.0 nM 383.62 O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cc(Cl)c(O)c(Cl)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4848515 OBDepict O HN N H O Cl S O O CH 3 Ki = 310.0 nM 376.82 CS(=O)(=O)c1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4869099 OBDepict CH 3 S HN O N H O F F F Ki = 320.0 nM 378.38 CSc1ccc(NC2=C(c3ccccc3C(F)(F)F)C(=O)NC2=O)cc1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4852765 OBDepict CH 3 O O N H NH O N Ki = 330.0 nM 395.42 COc1cc(-c2ccccc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4871372 OBDepict H 3 C O O N H N H O N Ki = 370.0 nM 345.36 COc1ccccc1C1=C(Nc2cccc3cccnc23)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4875291 OBDepict CH 3 O O N H HN O F O N Ki = 380.0 nM 519.53 COc1ccc(-c2ccc(OCc3ccccc3)c(F)c2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4862897 OBDepict H 3 C O NH O N H O O CH 3 Ki = 390.0 nM 324.34 COc1ccccc1NC1=C(c2ccccc2OC)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL158526 OBDepict CH 3 O O N H NH O S H 3 C Ki = 400.0 nM 340.4 COc1cccc(C2=C(Nc3ccc(SC)cc3)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4855533 OBDepict OH HN O N H O F F F Ki = 450.0 nM 348.28 O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4878043 OBDepict H 3 C S NH O N H O O CH 3 Ki = 490.0 nM 340.4 COc1ccccc1C1=C(Nc2ccccc2SC)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4870064 OBDepict CH 3 O O HN CH 3 O N H O O H 3 C Ki = 500.0 nM 354.36 COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)c(OC)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4879311 OBDepict CH 3 O O N H N H O O Ki = 510.0 nM 400.43 COc1ccccc1C1=C(Nc2cccc(OCc3ccccc3)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4870533 OBDepict N HN O N H O O CH 3 S Ki = 520.0 nM 401.45 COc1ccc(-c2ccsc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL402548 OBDepict CH 3 O H N O N N N H H O N N CH 3 IC50 = 621.0 nM 474.57 CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 Homo sapiens CHEMBL911847 single protein format
CHEMBL4869999 OBDepict CH 3 O O N H HN O N N Ki = 680.0 nM 396.41 COc1ccc(-c2cccnc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL4855005 OBDepict N HN O N H O O CH 3 O O Ki = 720.0 nM 453.45 COc1cc(-c2cccc3c2OCCO3)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL160373 OBDepict CH 3 O O N H NH O HO Ki = 740.0 nM 310.31 COc1cccc(C2=C(Nc3cccc(O)c3)C(=O)NC2=O)c1 Homo sapiens CHEMBL4839426 single protein format
CHEMBL4857914 OBDepict N HN O N H O O CH 3 O O Ki = 840.0 nM 453.45 COc1ccc(-c2cccc3c2OCCO3)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O Homo sapiens CHEMBL4839426 single protein format
CHEMBL103667 OBDepict O HN N H N N CH 3 CH 3 CH 3 O H 3 C N O IC50 < 1000.0 nM 527.67 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 Homo sapiens CHEMBL4602932 single protein format