HOME LIGAND hPROTEOME OTHERS DOCUMENT

Q9H2X6 | HIPK2_HUMAN | Homeodomain-interacting protein kinase 2 (HIPK2)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2062577 OBDepict N N N N N N H N CH 3 O H 3 C IC50 < 3.0 nM 385.43 CC(=O)N(C)c1ccc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 Homo sapiens CHEMBL2065460 single protein format
CHEMBL4228654 OBDepict CH 3 HN H 3 C N N N N O HO IC50 < 3.0 nM 373.42 CC(C)Nc1ccc2cnn(-c3cncc(-c4ccc(C(=O)O)cc4)n3)c2c1 Homo sapiens CHEMBL4222678 single protein format
CHEMBL2062581 OBDepict N N N N N H N H HN O CH 3 IC50 < 3.0 nM 371.4 CC(=O)Nc1ccc2[nH]cc(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 Homo sapiens CHEMBL2065460 single protein format
CHEMBL4750420 OBDepict H N N N O IC50 = 5.0 nM 311.34 c1ccc2cc(-c3coc4ccc(-c5cn[nH]c5)nc34)ccc2c1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4743939 OBDepict CH 3 O O N N N H IC50 = 15.0 nM 291.31 COc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL2062565 OBDepict N N N N N N H N HN O CH 3 IC50 = 20.0 nM 372.39 CC(=O)Nc1cnc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 Homo sapiens CHEMBL2065460 single protein format
CHEMBL4790791 OBDepict CH 3 N N O N N N H IC50 = 28.0 nM 265.28 Cn1cc(-c2coc3ccc(-c4cn[nH]c4)nc23)cn1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4754195 OBDepict CH 3 N N N O N IC50 = 29.0 nM 352.4 Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 Homo sapiens CHEMBL4728310 single protein format
CHEMBL3937369 OBDepict N O N N H N N N N N IC50 = 30.0 nM 416.49 c1cnc2ncn(-c3cc(Nc4ccc(OCCN5CCCCC5)cn4)ncn3)c2c1 Homo sapiens CHEMBL4329879 single protein format
CHEMBL4762964 OBDepict CH 3 N N N O N N H IC50 = 30.0 nM 341.37 Cn1cc(-c2ccc3occ(-c4cccc(-c5cc[nH]n5)c4)c3n2)cn1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL2062563 OBDepict N N N N N N H HN O CH 3 IC50 = 30.0 nM 371.4 CC(=O)Nc1ccc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 Homo sapiens CHEMBL2065460 single protein format
CHEMBL3103192 OBDepict H 2 N N H 3 C HN N H O CH 3 N HN N N N IC50 = 40.0 nM 419.49 CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN Homo sapiens CHEMBL3810701 single protein format
CHEMBL2409175 OBDepict N N N N N H NH N H CH 3 O CH 3 IC50 = 40.0 nM 361.41 CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C Homo sapiens CHEMBL2410931 single protein format
CHEMBL4743730 OBDepict H N N N O CH 2 H 3 C IC50 = 41.0 nM 301.35 C=C(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4790030 OBDepict H N N N O IC50 = 42.0 nM 261.28 c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL2062564 OBDepict N N N N N N H N HN O CH 3 IC50 = 50.0 nM 372.39 CC(=O)Nc1ccc2cnn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 Homo sapiens CHEMBL2065460 single protein format
CHEMBL2062575 OBDepict N N N N N NH N H N CH 3 H 3 C O CH 3 IC50 = 60.0 nM 416.49 CC(=O)Nc1ccc2ccn(-c3cc(NCCCN(C)C)n4ncc(C#N)c4n3)c2c1 Homo sapiens CHEMBL2065460 single protein format
CHEMBL4740998 OBDepict H N N N O CH 3 IC50 = 68.0 nM 315.38 CC1(c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)CC1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4797457 OBDepict H 3 C N N O N N N H 3 C IC50 = 70.0 nM 355.4 Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4587433 OBDepict O N H S O N H O N N HN IC50 = 74.0 nM 383.43 O=C1NC(=O)/C(=Cc2c[nH]c(=O)c(-c3ccc(N4CCNCC4)nc3)c2)S1 Homo sapiens CHEMBL4739038 single protein format
CHEMBL1336 OBDepict CH 3 NH O N O N H NH O Cl F F F IC50 = 100.0 nM 464.83 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 Homo sapiens CHEMBL4739040 single protein format
CHEMBL91829 OBDepict CH 3 N H 3 C H O N N O N H O IC50 = 100.0 nM 468.56 CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 Homo sapiens CHEMBL4739040 single protein format
CHEMBL4789951 OBDepict CH 3 N N N O N N H IC50 = 102.0 nM 341.37 Cn1cc(-c2ccc3occ(-c4cccc(-c5cn[nH]c5)c4)c3n2)cn1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4777288 OBDepict H N N N O H 3 C H 3 C CH 3 IC50 = 119.0 nM 317.39 CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4778153 OBDepict H N N N N O H 3 C H 3 C CH 3 IC50 = 123.0 nM 318.38 CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]n4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4778370 OBDepict H N N N O IC50 = 172.0 nM 337.38 c1ccc(-c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4791451 OBDepict CH 3 N N N O NH IC50 = 179.0 nM 358.45 Cn1cc(-c2ccc3occ(-c4cccc(C5CCNCC5)c4)c3n2)cn1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4741919 OBDepict CH 3 N O N N N CH 3 IC50 = 260.0 nM 372.47 CN1CCC(c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)CC1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4856136 OBDepict CH 3 NH H 3 C N O _ O + Na IC50 = 300.0 nM 316.34 CCC(C)Nc1cc2cc(C(=O)[O-])ccc2c2cnccc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4856667 OBDepict _ O O HN N + Na IC50 = 300.0 nM 314.32 O=C([O-])c1ccc2c(c1)cc(NC1CCC1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4862671 OBDepict _ O O N N + Na IC50 = 300.0 nM 328.35 O=C([O-])c1ccc2c(c1)cc(N1CCCCC1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4871816 OBDepict CH 3 NH H 3 C N O _ O + Na IC50 = 300.0 nM 302.31 CC(C)Nc1cc2cc(C(=O)[O-])ccc2c2cnccc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4870585 OBDepict _ O O Br Cl N + Na IC50 = 300.0 nM 358.55 O=C([O-])c1ccc2c(c1)cc(Br)c1ccnc(Cl)c12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4867336 OBDepict _ O + N O N O _ O + Na IC50 = 300.0 nM 290.21 O=C([O-])c1ccc2c(c1)cc([N+](=O)[O-])c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4862119 OBDepict _ O O N + Na IC50 = 300.0 nM 285.28 O=C([O-])c1ccc2c(c1)cc(C1CC1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4871728 OBDepict _ O O Br N + Na IC50 < 300.0 nM 324.11 O=C([O-])c1ccc2c(c1)cc(Br)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4855218 OBDepict _ O O N H N + Na IC50 = 300.0 nM 328.35 O=C([O-])c1ccc2c(c1)cc(NC1CCCC1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4876205 OBDepict NH 2 O Br NH 2 N IC50 = 300.0 nM 316.16 NC(=O)c1ccc2c(c1)cc(Br)c1ccnc(N)c12 Homo sapiens CHEMBL4807032 single protein format
CHEMBL4867675 OBDepict H 3 C NH H 3 C H N O _ O + Na IC50 < 300.0 nM 316.34 CC[C@@H](C)Nc1cc2cc(C(=O)[O-])ccc2c2cnccc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4877989 OBDepict _ O O N H N + Na IC50 < 300.0 nM 300.29 O=C([O-])c1ccc2c(c1)cc(NC1CC1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4850936 OBDepict N N O _ O + Na IC50 = 300.0 nM 270.22 N#Cc1cc2cc(C(=O)[O-])ccc2c2cnccc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4871526 OBDepict _ O O N H N + Na IC50 = 300.0 nM 342.37 O=C([O-])c1ccc2c(c1)cc(NC1CCCCC1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4874005 OBDepict _ O O Cl N + Na IC50 = 300.0 nM 279.66 O=C([O-])c1ccc2c(c1)cc(Cl)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4852867 OBDepict _ O O Br NH 2 N + Na IC50 < 300.0 nM 339.12 Nc1nccc2cc(Br)c3cc(C(=O)[O-])ccc3c12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4849181 OBDepict NH 2 N N O _ O + Na IC50 = 300.0 nM 337.31 Nc1ccc(-c2cc3cc(C(=O)[O-])ccc3c3cnccc23)cn1.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4855827 OBDepict _ O O CH 3 N + Na IC50 = 300.0 nM 259.24 Cc1cc2cc(C(=O)[O-])ccc2c2cnccc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4869607 OBDepict Cl N H N O _ O + Na IC50 = 300.0 nM 370.77 O=C([O-])c1ccc2c(c1)cc(Nc1ccc(Cl)cc1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4864298 OBDepict Cl N H N O _ O + Na IC50 = 300.0 nM 370.77 O=C([O-])c1ccc2c(c1)cc(Nc1cccc(Cl)c1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4853293 OBDepict _ O O Br NH 2 N + Na IC50 < 300.0 nM 339.12 Nc1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4795076 OBDepict O N Br N N O Br Br H Br IC50 = 330.0 nM 528.78 O=C1c2c(Br)c(Br)c(Br)c(Br)c2C(=O)N1c1ncc[nH]1 Homo sapiens CHEMBL4739037 single protein format
CHEMBL4777533 OBDepict H N N N N N O H 3 C H 3 C CH 3 IC50 = 357.0 nM 319.37 CC(C)(C)c1ccc(-c2coc3ccc(-c4nn[nH]n4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4789373 OBDepict H N N N O IC50 = 484.0 nM 351.41 c1ccc(Cc2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4794825 OBDepict CH 3 CH 3 O N N N H IC50 = 501.0 nM 317.39 CC(C)Cc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL2062585 OBDepict N N N N N H N N H O HO O H 3 C IC50 = 570.0 nM 443.47 CC(=O)Nc1ccc2c(c1)c(-c1cc(NC3CC3)n3ncc(C#N)c3n1)cn2CCC(=O)O Homo sapiens CHEMBL2065460 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 585.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328445 single protein format
CHEMBL4777540 OBDepict H N N N O IC50 = 654.0 nM 343.43 c1n[nH]cc1-c1ccc2occ(-c3ccc(C4CCCCC4)cc3)c2n1 Homo sapiens CHEMBL4739023 single protein format
CHEMBL4870359 OBDepict H 3 C O N Br O _ O + Na IC50 = 1000.0 nM 354.13 COc1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4855950 OBDepict OH O N H N H N H IC50 = 1000.0 nM 321.38 O=C(O)c1ccc2c(c1)cc(N[C@@H]1CCCNC1)c1ccncc12 Homo sapiens CHEMBL4807032 single protein format
CHEMBL4846302 OBDepict _ O O Br N N H + Na IC50 = 1000.0 nM 379.19 O=C([O-])c1ccc2c(c1)cc(Br)c1ccnc(NC3CC3)c12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4856281 OBDepict H N N N O _ O + Na IC50 = 1000.0 nM 311.28 O=C([O-])c1ccc2c(c1)cc(-c1cc[nH]n1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4852889 OBDepict _ O O N + Na IC50 = 1000.0 nM 245.21 O=C([O-])c1ccc2c(ccc3ccncc32)c1.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4848434 OBDepict _ O O Cl N + Na IC50 = 1000.0 nM 279.66 O=C([O-])c1ccc2c(ccc3ccnc(Cl)c32)c1.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4878788 OBDepict Cl N O _ O + Na IC50 = 1000.0 nM 355.76 O=C([O-])c1ccc2c(c1)cc(-c1ccc(Cl)cc1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4855640 OBDepict _ O O N N + Na IC50 = 1000.0 nM 322.3 O=C([O-])c1ccc2c(c1)cc(-c1cccnc1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4867159 OBDepict CH 3 NH H 3 C H N O OH IC50 = 1000.0 nM 294.35 CC[C@H](C)Nc1cc2cc(C(=O)O)ccc2c2cnccc12 Homo sapiens CHEMBL4807032 single protein format
CHEMBL4858891 OBDepict _ O O N N + Na IC50 = 1000.0 nM 322.3 O=C([O-])c1ccc2c(c1)cc(-c1ccncc1)c1ccncc12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4856868 OBDepict H 3 C NH N Br O _ O + Na IC50 = 1000.0 nM 353.15 CNc1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12.[Na+] Homo sapiens CHEMBL4807032 single protein format
CHEMBL4879266 OBDepict H 3 C N CH 3 N Br O _ O + Na IC50 = 1000.0 nM 367.18 CN(C)c1nccc2c(Br)cc3cc(C(=O)[O-])ccc3c12.[Na+] Homo sapiens CHEMBL4807032 single protein format