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Q9H4A3 | WNK1_HUMAN | Serine/threonine-protein kinase WNK1 (WNK1)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -105500.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804510 cell-based format
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -69300.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804510 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -31800.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804510 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -8300.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804510 cell-based format
CHEMBL4088706 OBDepict CH 3 N H S N N Cl N O N Cl IC50 = 4.0 nM 462.41 CNc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cn2)cs1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4098876 OBDepict Cl N N O Cl N N S N H D D D IC50 = 6.0 nM 465.42 [2H]C([2H])([2H])Nc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cn2)cs1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4087727 OBDepict CH 3 O N N H Ki = 32.43 nM 424.59 COc1cccc(-c2cccc(-n3cc(CNCC4CCCCC4)c4ccccc43)c2)c1 Homo sapiens CHEMBL4041141 assay format
CHEMBL4091128 OBDepict CH 3 O N N N H F IC50 = 39.0 nM 443.57 COc1cccc(-c2cc(-n3cc(CNCC4CCCCC4)c4ccc(F)cc43)ccn2)c1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4065531 OBDepict CH 3 O N N N H IC50 = 60.0 nM 425.58 COc1cccc(-c2cc(-n3cc(CNCC4CCCCC4)c4ccccc43)ccn2)c1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4070177 OBDepict CH 3 O N N CH 3 N H CH 3 CH 3 IC50 = 95.0 nM 399.54 COc1cccc(-c2cc(-n3cc(CNCC(C)C)c4ccccc43)c(C)cn2)c1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4060478 OBDepict CH 3 N H S N N N O N Cl IC50 = 106.0 nM 427.96 CNc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)ccn2)cs1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4087727 OBDepict CH 3 O N N H IC50 = 162.0 nM 424.59 COc1cccc(-c2cccc(-n3cc(CNCC4CCCCC4)c4ccccc43)c2)c1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = 200.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804510 cell-based format
CHEMBL4100485 OBDepict CH 3 N H S N N O O Cl IC50 = 420.0 nM 476.0 CNc1nc(-c2ccc3c(c2)CCN3C(=O)c2ccccc2OCc2ccc(Cl)cc2)cs1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4070968 OBDepict CH 3 O N N O N IC50 = 623.0 nM 437.54 COc1cccc(-c2cc(C(=O)N3CCN(Cc4ccccc4)CC3)c3ccccc3n2)c1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4083340 OBDepict H 3 C O N N O CH 3 H N Cl IC50 = 750.0 nM 486.02 COc1cccc(-c2cc(C(=O)N(C)[C@@H]3CCN(Cc4ccc(Cl)cc4)C3)c3ccccc3n2)c1 Homo sapiens CHEMBL4041133 assay format
CHEMBL4061509 OBDepict CH 3 O N N O N Cl IC50 = 971.0 nM 421.93 COc1cccc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)ccn2)c1 Homo sapiens CHEMBL4041133 assay format