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Q9H5I1 | SUV92_HUMAN | Histone-lysine N-methyltransferase SUV39H2 (SUV39H2)

3D structures mapped by conservation among orthologs

[ Domain: "Zn3Cys9 preSET domain-related" // Pre-SET ]

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[ Domain: "SET domain-like" // SET ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4587289 OBDepict CH 3 O O N CH 3 Cl N N N P O O O H 3 C H 3 C IC50 = 1.77 nM 480.89 COc1cc(OC)c(-c2cn3ccc(N4CCN(P(=O)(OC)OC)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4553838 OBDepict CH 3 O N O CH 3 N N N O Cl H 3 C O H 3 C IC50 = 1.78 nM 458.95 COCC(=O)N1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1C Homo sapiens CHEMBL4477004 single protein format
CHEMBL4563069 OBDepict CH 3 O N O N H 3 C N N O Cl H 3 C O H 3 C IC50 = 1.88 nM 458.95 COCC(=O)N1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)C(C)C1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4520078 OBDepict H 3 C O O N H 3 C Cl N N N CH 3 O CH 3 IC50 = 1.97 nM 428.92 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(C)=O)C(C)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4551654 OBDepict CH 3 O O N CH 3 Cl N N N O H 3 C IC50 = 2.0 nM 414.89 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(C)=O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4556599 OBDepict CH 3 O Cl O N N N H 3 C CH 3 N HN IC50 = 2.07 nM 458.01 COc1cc(OCCCN(C)C)c(-c2cn3ccc(N4CCCNCC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4556449 OBDepict H 2 N NH N N N N S O O O Cl CH 3 O CH 3 IC50 = 2.2 nM 535.07 COc1cc(OC)c(-c2cn3cc(NCCN)c(N4CCN(S(=O)(=O)C5CC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4457187 OBDepict NH 2 NH N O CH 3 N O Cl H 3 C O H 3 C IC50 = 2.71 nM 376.84 COc1cc(OC)c(-c2cn3cc(NCCN)c(OC)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4534136 OBDepict H 3 C O P O O N CH 3 N N N O Cl CH 3 O CH 3 IC50 = 2.9 nM 551.02 CCOP(=O)(CCN1CCCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1)OCC Homo sapiens CHEMBL4477004 single protein format
CHEMBL4551056 OBDepict CH 3 O O N CH 3 Br N N N N H 3 C CH 3 IC50 = 3.0 nM 502.46 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCCN(C)C)CC4)cc3n2)cc1Br Homo sapiens CHEMBL4477004 single protein format
CHEMBL4547529 OBDepict CH 3 O O N CH 3 Cl N N BrH IC50 = 3.1 nM 438.75 Br.COc1cc(OC)c(-c2cn3ccc(N4CCCC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4589569 OBDepict CH 3 O O N CH 3 Cl N N N H O CH 3 IC50 = 3.27 nM 428.92 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(C)=O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4558804 OBDepict CH 3 O O N CH 3 Cl N N N CH 3 O O H 3 C H 3 C CH 3 IC50 = 3.33 nM 487.0 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(=O)OC(C)(C)C)C(C)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4514527 OBDepict NH 2 HN N N N O O Cl CH 3 O CH 3 IC50 = 3.35 nM 431.92 COc1cc(OC)c(-c2cn3cc(NCCN)c(N4CCOCC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4569911 OBDepict CH 3 O O N CH 3 Br N N N N O IC50 = 3.49 nM 530.47 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCN5CCOCC5)CC4)cc3n2)cc1Br Homo sapiens CHEMBL4477004 single protein format
CHEMBL4536861 OBDepict CH 3 O O N CH 3 Cl N N CH 3 N O H 3 C IC50 = 3.5 nM 428.92 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(C)=O)CC4C)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4557178 OBDepict H 3 C O O N H 3 C Cl N N N HN O N CH 3 CH 3 IC50 = 3.53 nM 515.06 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCC(=O)NCCN(C)C)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4543316 OBDepict CH 3 O O N CH 3 N N N BrH IC50 = 3.71 nM 429.32 Br.COc1cc(OC)c(-c2cn3ccc(N4CCCC4)cc3n2)cc1C#N Homo sapiens CHEMBL4477004 single protein format
CHEMBL4532138 OBDepict CH 3 O O N CH 3 Cl N N N H S O O CH 3 IC50 = 3.81 nM 450.95 COc1cc(OC)c(-c2cn3ccc(N4CCC(NS(C)(=O)=O)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4534069 OBDepict CH 3 O O N CH 3 Cl N N N H 3 C S O O CH 3 IC50 = 3.81 nM 464.98 COc1cc(OC)c(-c2cn3ccc(N4CCN(S(C)(=O)=O)C(C)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4542129 OBDepict CH 3 O O N H 3 C Cl N N N H S O O IC50 = 3.95 nM 476.99 COc1cc(OC)c(-c2cn3ccc(N4CCC(NS(=O)(=O)C5CC5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4483505 OBDepict CH 3 O O N CH 3 Cl N N H N H O N IC50 = 4.03 nM 477.95 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NC(=O)c5ccccn5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4513598 OBDepict CH 3 O O N CH 3 Cl N N N H O NH 2 IC50 = 4.11 nM 415.88 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(N)=O)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4546702 OBDepict H 3 C O O N H 3 C Cl N N N O IC50 = 4.16 nM 440.93 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(=O)C5CC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4531530 OBDepict NH 2 NH N CH 3 N O Cl H 3 C O H 3 C IC50 = 4.31 nM 360.85 COc1cc(OC)c(-c2cn3cc(NCCN)c(C)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4540137 OBDepict CH 3 O O N CH 3 Cl N N HN IC50 = 4.33 nM 386.88 COc1cc(OC)c(-c2cn3ccc(N4CCCNCC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4515775 OBDepict CH 3 O O N CH 3 Cl N N N H P O O O H 3 C H 3 C IC50 = 4.35 nM 494.92 COc1cc(OC)c(-c2cn3ccc(N4CCC(NP(=O)(OC)OC)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4521461 OBDepict CH 3 O O N CH 3 Cl N N N H O CH 3 IC50 = 4.35 nM 414.89 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(C)=O)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4545245 OBDepict CH 3 O O N CH 3 Cl N N N N IC50 = 4.4 nM 470.02 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCN5CCCC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4561226 OBDepict CH 3 O O N CH 3 Cl N N N O H 2 N IC50 = 4.54 nM 443.94 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCC(N)=O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4580507 OBDepict CH 3 O O N CH 3 Cl N N HO IC50 = 4.88 nM 387.87 COc1cc(OC)c(-c2cn3ccc(N4CCC(O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4585867 OBDepict CH 3 O O N CH 3 Cl N N CH 3 N S O O CH 3 IC50 = 4.94 nM 464.98 COc1cc(OC)c(-c2cn3ccc(N4CCN(S(C)(=O)=O)CC4C)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4575122 OBDepict H 3 C O O N H 3 C Cl N N N N N N NH 2 IC50 = 4.99 nM 549.08 COc1cc(OC)c(-c2cn3ccc(N4CCN(c5ncc(N6CCC(N)CC6)cn5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4576486 OBDepict CH 3 O O N CH 3 Cl N N N N IC50 = 5.05 nM 478.0 COc1cc(OC)c(-c2cn3ccc(N4CCCN(Cc5ccncc5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4573226 OBDepict H 2 N NH N H O N N N O Cl CH 3 O CH 3 IC50 = 5.14 nM 458.95 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(=O)NCCN)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4586982 OBDepict CH 3 O O N CH 3 Cl N N CH 3 H 3 C BrH IC50 = 5.15 nM 412.72 Br.COc1cc(OC)c(-c2cn3ccc(N(C)C)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4561677 OBDepict CH 3 O HN O H H N H N N O Cl H 3 C O H 3 C IC50 = 5.24 nM 458.95 COC(=O)N[C@H]1CC[C@H](Nc2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4543399 OBDepict CH 3 O Cl O N N N H 3 C CH 3 N IC50 = 5.31 nM 428.96 COc1cc(OCCCN(C)C)c(-c2cn3ccc(N4CCCC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4554934 OBDepict CH 3 O Cl O N N N IC50 = 5.38 nM 397.91 COc1cc(OCC2CC2)c(-c2cn3ccc(N4CCCC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4591003 OBDepict OH N N N O Cl H 3 C O H 3 C IC50 = 5.4 nM 401.89 COc1cc(OC)c(-c2cn3ccc(N4CCC(CO)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4528102 OBDepict CH 3 O O N CH 3 Br N N HO IC50 = 5.44 nM 418.29 COc1cc(OC)c(-c2cn3ccc(N4CCC(O)C4)cc3n2)cc1Br Homo sapiens CHEMBL4477004 single protein format
CHEMBL4582832 OBDepict H 3 C O O N CH 3 Cl N N N S O O CH 3 IC50 = 5.61 nM 479.0 CCS(=O)(=O)N1CCCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4513575 OBDepict CH 3 O O N CH 3 Cl N N N S O O IC50 = 5.74 nM 491.01 COc1cc(OC)c(-c2cn3ccc(N4CCCN(S(=O)(=O)C5CC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4557490 OBDepict H 2 N N H O N N N O Cl CH 3 O CH 3 IC50 = 5.75 nM 443.94 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(=O)CCN)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4515431 OBDepict H 2 N N CH 3 N N O Cl CH 3 O CH 3 IC50 = 5.85 nM 360.85 COc1cc(OC)c(-c2cn3ccc(N(C)CCN)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4530406 OBDepict H 2 N NH N N N N N S O O O Cl CH 3 O CH 3 IC50 = 5.97 nM 536.06 COc1cc(OC)c(-c2cn3cc(NCCN)c(N4CCN(S(=O)(=O)C5CC5)CC4)nc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4593564 OBDepict CH 3 O O N H 3 C Cl N N N H N S O O IC50 = 6.05 nM 574.15 COc1cc(OC)c(-c2cn3ccc(N4CCC(NCC5CCN(S(=O)(=O)C6CC6)CC5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4516650 OBDepict CH 3 O N O N N N O Cl H 3 C O H 3 C IC50 = 6.06 nM 430.89 COC(=O)N1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4553698 OBDepict CH 3 O O N CH 3 Cl N N N BrH IC50 = 6.08 nM 439.74 Br.COc1cc(OC)c(-c2cn3ccc(N4CCCC4)nc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4539124 OBDepict CH 3 O O N CH 3 Cl N N N O OH IC50 = 6.3 nM 458.95 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCCC(=O)O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4531135 OBDepict CH 3 O O N CH 3 Cl N N H N H N Cl IC50 = 6.35 nM 498.41 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NCc5ccnc(Cl)c5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4519887 OBDepict CH 3 O O N CH 3 Cl N N N H O O CH 3 H 3 C CH 3 IC50 = 6.35 nM 472.97 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(=O)OC(C)(C)C)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4574823 OBDepict CH 3 O O N CH 3 Cl N N N N IC50 = 6.37 nM 463.97 COc1cc(OC)c(-c2cn3ccc(N4CCN(Cc5ccncc5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4546598 OBDepict CH 3 O P O O N H 3 C N N N O Cl CH 3 O CH 3 IC50 = 6.4 nM 537.0 CCOP(=O)(CCN1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1)OCC Homo sapiens CHEMBL4477004 single protein format
CHEMBL4576776 OBDepict H 3 C O O N H 3 C Cl N N N S O O CH 3 IC50 = 6.4 nM 464.98 COc1cc(OC)c(-c2cn3ccc(N4CCCN(S(C)(=O)=O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4577844 OBDepict CH 3 O O N CH 3 Cl N N N IC50 = 6.46 nM 483.06 COc1cc(OC)c(-c2cn3ccc(N4CCCN(CC5CCCCC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4579951 OBDepict CH 3 O O N CH 3 Cl N N H N H N IC50 = 6.49 nM 463.97 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NCc5ccncc5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4547214 OBDepict HO N N S O O N N O Cl CH 3 O CH 3 IC50 = 6.55 nM 507.01 COc1cc(OC)c(-c2cn3ccc(N4CCN(S(=O)(=O)C5CC5)C(CO)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4583711 OBDepict F N N N N O Cl H 3 C O H 3 C IC50 = 6.66 nM 418.9 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCF)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4483443 OBDepict CH 3 S O O N CH 3 Cl N N N S O O IC50 = 6.72 nM 523.08 COc1cc(OCSC)c(-c2cn3ccc(N4CCN(S(=O)(=O)C5CC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4560657 OBDepict CH 3 O O N CH 3 Cl N N N H S O O IC50 = 6.72 nM 505.04 COc1cc(OC)c(-c2cn3ccc(N4CCC(CNS(=O)(=O)C5CC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4515454 OBDepict H 3 C O O N H 3 C Cl N N N S N O O CH 3 H 3 C IC50 = 6.74 nM 494.02 COc1cc(OC)c(-c2cn3ccc(N4CCCN(S(=O)(=O)N(C)C)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4588422 OBDepict CH 3 O O N CH 3 Cl N N H N H H HO N IC50 = 6.76 nM 479.97 COc1cc(OC)c(-c2cn3ccc(N4C[C@H](O)[C@@H](NCc5ccncc5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4514753 OBDepict H 3 C N H N N N N N N N O Cl CH 3 O CH 3 IC50 = 6.81 nM 549.08 CNC1CCN(c2ncc(N3CCN(c4ccn5cc(-c6cc(Cl)c(OC)cc6OC)nc5c4)CC3)cn2)C1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4534798 OBDepict CH 3 O O N CH 3 Cl N N H N H N F IC50 = 6.83 nM 481.96 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NCc5ccnc(F)c5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4551871 OBDepict CH 3 O O N CH 3 Cl N N N S O O IC50 = 6.97 nM 491.01 COc1cc(OC)c(-c2cn3ccc(N4CCC(N5CCCS5(=O)=O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4562452 OBDepict CH 3 O O N CH 3 Cl N N H 2 N IC50 = 7.04 nM 372.86 COc1cc(OC)c(-c2cn3ccc(N4CCC(N)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4594029 OBDepict CH 3 O O N CH 3 Cl N N H N H N O O H 3 C H 3 C H 3 C IC50 = 7.15 nM 570.13 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NCC5CCN(C(=O)OC(C)(C)C)CC5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4483733 OBDepict CH 3 O O N CH 3 Cl N N H N H N IC50 = 7.21 nM 463.97 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NCc5ccccn5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4565002 OBDepict CH 3 O O N CH 3 Cl N N N O OH IC50 = 7.29 nM 492.96 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(=O)c5ccccc5O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4541424 OBDepict H 3 C O O N H 3 C Cl N N N N N N NH 2 IC50 = 7.35 nM 549.08 COc1cc(OC)c(-c2cn3ccc(N4CCN(c5cnc(N6CCC(N)CC6)nc5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4535425 OBDepict CH 3 O O N CH 3 Br N N N N H O CH 3 IC50 = 7.47 nM 460.33 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(C)=O)C4)nc3n2)cc1Br Homo sapiens CHEMBL4477004 single protein format
CHEMBL4555676 OBDepict CH 3 O O N CH 3 Cl N N N N N IC50 = 7.47 nM 450.93 COc1cc(OC)c(-c2cn3ccc(N4CCN(c5cnccn5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4586940 OBDepict CH 3 O O N CH 3 N N N N H O O CH 3 H 3 C CH 3 IC50 = 7.5 nM 463.54 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(=O)OC(C)(C)C)C4)cc3n2)cc1C#N Homo sapiens CHEMBL4477004 single protein format
CHEMBL4570818 OBDepict CH 3 O O N CH 3 Cl N N N H 3 C CH 3 IC50 = 7.68 nM 428.96 COc1cc(OC)c(-c2cn3ccc(N4CCC(CN(C)C)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4549776 OBDepict H 3 C O O N H 3 C Cl N N N O IC50 = 7.68 nM 468.99 COc1cc(OC)c(-c2cn3ccc(N4CCN(C(=O)C5CCCC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4571313 OBDepict CH 3 O O N CH 3 Cl N N N H O O CH 3 H 3 C CH 3 IC50 = 7.69 nM 487.0 COc1cc(OC)c(-c2cn3ccc(N4CCC(CNC(=O)OC(C)(C)C)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4535565 OBDepict CH 3 O O N CH 3 Cl N N H N H H 3 C N IC50 = 7.7 nM 478.0 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NC(C)c5ccncc5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4534510 OBDepict CH 3 O O N CH 3 Cl N N N H O H 3 C H 3 C CH 3 IC50 = 7.71 nM 471.0 COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(=O)C(C)(C)C)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4483497 OBDepict CH 3 O O N CH 3 Cl N N N N IC50 = 7.74 nM 449.94 COc1cc(OC)c(-c2cn3ccc(N4CCN(c5ccccn5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4570097 OBDepict CH 3 O O N CH 3 Cl N N N N HN IC50 = 7.85 nM 485.03 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCN5CCNCC5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4567597 OBDepict N N N N N O Cl CH 3 O CH 3 IC50 = 8.07 nM 411.89 COc1cc(OC)c(-c2cn3ccc(N4CCN(CC#N)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4535594 OBDepict CH 3 O N H O N N N O Cl H 3 C O H 3 C IC50 = 8.14 nM 444.92 COC(=O)NC1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4542763 OBDepict CH 3 O O N CH 3 Cl N H 2 N ClH IC50 = 8.27 nM 340.21 COc1cc(OC)c(-c2cn3ccc(N)cc3n2)cc1Cl.Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4573065 OBDepict CH 3 O O N CH 3 Cl N N N N N IC50 = 8.29 nM 476.97 COc1cc(OC)c(-c2cn3ccc(N4CCN(/N=Cc5ccncc5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4521937 OBDepict CH 3 O O N CH 3 Cl N N H H 2 N ClH ClH IC50 = 8.29 nM 445.78 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](N)C4)cc3n2)cc1Cl.Cl.Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4564004 OBDepict CH 3 O O N CH 3 Cl N N N N H O O H 3 C CH 3 H 3 C IC50 = 8.31 nM 516.04 COc1cc(OC)c(-c2cn3ccc(N4CCC(CCNC(=O)OC(C)(C)C)CC4)nc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4590505 OBDepict CH 3 O N N N N O Cl H 3 C O H 3 C IC50 = 8.33 nM 444.96 COCCCN1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4519801 OBDepict CH 3 N H N N N O Cl H 3 C O H 3 C IC50 = 8.41 nM 457.02 CCCCCNC1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4535029 OBDepict HO N N N N O Cl CH 3 O CH 3 ClH ClH IC50 = 8.54 nM 489.83 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCO)CC4)cc3n2)cc1Cl.Cl.Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4544836 OBDepict CH 3 O O N CH 3 Br N N N IC50 = 8.58 nM 403.28 COc1cc(OC)c(-c2cn3ccc(N4CCCC4)nc3n2)cc1Br Homo sapiens CHEMBL4477004 single protein format
CHEMBL4534751 OBDepict CH 3 O O N H 3 C Cl N N N S O O O N H 3 C CH 3 IC50 = 8.63 nM 578.14 COc1cc(OC)c(-c2cn3ccc(N4CCN(S(=O)(=O)C5CC5)C(COCCN(C)C)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4525915 OBDepict NH 2 HN N N N N HN O Cl CH 3 O CH 3 IC50 = 8.66 nM 431.93 COc1cc(OC)c(-c2cn3cc(NCCN)c(N4CCNCC4)nc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4514359 OBDepict H 2 N N N N O Cl CH 3 O CH 3 ClH ClH IC50 = 8.75 nM 487.86 COc1cc(OC)c(-c2cn3ccc(N4CCC(CCN)CC4)cc3n2)cc1Cl.Cl.Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4571462 OBDepict H 3 C O N H H N N N O Cl H 3 C O H 3 C IC50 = 8.81 nM 493.01 COc1ccc(CN[C@H]2CCN(c3ccn4cc(-c5cc(Cl)c(OC)cc5OC)nc4c3)C2)cc1 Homo sapiens CHEMBL4477004 single protein format
CHEMBL4573508 OBDepict CH 3 O O N CH 3 Cl N N N N N NH 2 IC50 = 8.81 nM 465.95 COc1cc(OC)c(-c2cn3ccc(N4CCN(c5nccc(N)n5)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4565001 OBDepict CH 3 O O N CH 3 Cl N N N H S O O CH 3 IC50 = 8.83 nM 464.98 COc1cc(OC)c(-c2cn3ccc(N4CCC(NS(C)(=O)=O)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4579318 OBDepict CH 3 O O N CH 3 Cl N N N N CH 3 H 3 C IC50 = 8.84 nM 443.98 COc1cc(OC)c(-c2cn3ccc(N4CCN(CCN(C)C)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4549809 OBDepict CH 3 O O N CH 3 Cl N N N CH 3 H 3 C IC50 = 8.87 nM 442.99 COc1cc(OC)c(-c2cn3ccc(N4CCC(CCN(C)C)CC4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format
CHEMBL4555239 OBDepict CH 3 O O N CH 3 Cl N N H N H + N O _ O IC50 = 8.88 nM 507.98 COc1cc(OC)c(-c2cn3ccc(N4CC[C@H](NCc5ccc([N+](=O)[O-])cc5)C4)cc3n2)cc1Cl Homo sapiens CHEMBL4477004 single protein format