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Q9NR22 | ANM8_HUMAN | Protein arginine N-methyltransferase 8 (PRMT8)

3D structures mapped by conservation among orthologs

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]

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[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4094513 OBDepict NH 2 N CH 3 S Cl IC50 = 1.1 nM 306.86 CN(CCN)Cc1ccccc1Sc1ccccc1Cl Homo sapiens CHEMBL4026505 single protein format
CHEMBL3589029 OBDepict NH 2 N H 3 C N N H O IC50 = 2.0 nM 322.41 CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3901808 OBDepict NH 2 N CH 3 N H O H 3 C CH 3 IC50 = 4.0 nM 287.41 CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 Homo sapiens CHEMBL3859041 single protein format
CHEMBL3589030 OBDepict NH 2 N CH 3 N N H Cl O CH 3 H 3 C IC50 = 7.0 nM 322.84 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1Cl Homo sapiens CHEMBL3591483 assay format
CHEMBL3589031 OBDepict CH 3 HN N CH 3 N N H Cl O CH 3 H 3 C IC50 = 10.0 nM 336.87 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589026 OBDepict NH 2 N CH 3 N N H O CH 3 H 3 C IC50 = 10.0 nM 288.4 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589028 OBDepict NH 2 N CH 3 N N H CH 3 H 3 C IC50 = 10.0 nM 286.42 CC(C)Cc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589027 OBDepict CH 3 HN N CH 3 N N H O H 3 C CH 3 IC50 = 14.0 nM 302.42 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589037 OBDepict CH 3 N H N H 3 C N N H O F F F IC50 = 21.0 nM 438.54 CNCCN(C)Cc1cn[nH]c1-c1cc(OCCC2CCCCC2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589032 OBDepict CH 3 HN N CH 3 N N CH 3 Cl O CH 3 H 3 C IC50 = 22.0 nM 350.89 CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589033 OBDepict H 3 C NH N H 3 C N N H O OH CH 3 IC50 = 22.0 nM 332.45 CCC(CO)Oc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589036 OBDepict CH 3 N H N H 3 C N N H O F F F IC50 = 23.0 nM 432.49 CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589913 OBDepict H 3 C NH N H 3 C N N H O CH 3 IC50 = 28.0 nM 288.4 CCOc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589038 OBDepict CH 3 HN N CH 3 N N H O F F F OH CH 3 CH 3 IC50 = 44.0 nM 428.5 CNCCN(C)Cc1cn[nH]c1-c1cc(OC(CO)CC(C)C)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589034 OBDepict CH 3 HN N CH 3 N N H O CH 3 H 3 C HO IC50 = 55.0 nM 346.48 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(CO)C(C)C)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3590417 OBDepict CH 3 HN N CH 3 N N H O N H O CH 3 IC50 = 65.0 nM 393.49 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589912 OBDepict H 2 N N CH 3 N N H F IC50 = 67.0 nM 248.31 CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589035 OBDepict H 2 N N H 3 C N N H Cl O F F F CH 3 H 3 C IC50 = 70.0 nM 390.84 CC(C)Oc1c(Cl)cc(-c2c[nH]nc2CN(C)CCN)cc1C(F)(F)F Homo sapiens CHEMBL3591483 assay format
CHEMBL4463793 OBDepict NH 2 N CH 3 N H NH O H 2 C IC50 = 110.0 nM 298.39 C=CC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346592 single protein format
CHEMBL4544587 OBDepict NH 2 N CH 3 N H NH O H 3 C IC50 = 130.0 nM 300.41 CCC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346592 single protein format
CHEMBL3589042 OBDepict H 3 C NH N H 3 C N N H O N O H 3 C CH 3 IC50 = 179.0 nM 407.52 CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589039 OBDepict CH 3 NH N H 3 C N N H O H H O O IC50 = 223.0 nM 442.6 CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@H](OCCC3CCOCC3)C2)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589043 OBDepict H 3 C NH N H 3 C N N H O N O H 3 C CH 3 IC50 = 347.0 nM 407.52 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3589040 OBDepict H 2 N N CH 3 N N H O N O IC50 = 450.0 nM 373.5 CN(CCN)Cc1c[nH]nc1-c1ccc(OCCCN2CCOCC2)cc1 Homo sapiens CHEMBL3591483 assay format
CHEMBL3970878 OBDepict CH 3 N H N O IC50 = 573.0 nM 324.47 CNCCN1CCC(OCc2cccc(-c3ccccc3)c2)CC1 Homo sapiens CHEMBL3859049 single protein format