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Q9NZQ8 | TRPM5_HUMAN | Transient receptor potential cation channel subfamily M member 5 (TRPM5)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3932326 OBDepict H 3 C O O H 3 C N N H O N Cl H 3 C IC50 = 1.3 nM 399.88 COc1ccc(/C=N/NC(=O)CCn2cc(Cl)c3c(C)cccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3926856 OBDepict CH 3 O N N N H O N H 3 C H 3 C IC50 = 1.4 nM 400.48 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3921169 OBDepict H 3 C O O H 3 C N N H O N H 3 C H 3 C IC50 = 1.8 nM 379.46 COc1ccc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3984818 OBDepict CH 3 O O CH 3 N F N H O N H 3 C H 3 C IC50 = 3.0 nM 397.45 COc1cc(F)c(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3890861 OBDepict O N H N N H 3 C H 3 C H 3 C N IC50 = 5.0 nM 384.48 Cc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3920665 OBDepict CH 3 O O CH 3 N N H O N CH 3 O H 3 C IC50 = 6.0 nM 395.46 COc1ccc(/C=N/NC(=O)CCn2cc(C)c3c(OC)cccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3958181 OBDepict H 3 C O O H 3 C N N H O N H 3 C H 3 C IC50 = 9.0 nM 379.46 COc1ccc(/C=N/NC(=O)CCc2cn(C)c3c(C)cccc23)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3917255 OBDepict CH 3 O O CH 3 N N H O N CH 3 IC50 = 12.0 nM 365.43 COc1ccc(/C=N/NC(=O)CCn2ccc3c(C)cccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3952275 OBDepict CH 3 O O CH 3 N N H O N CH 3 IC50 = 17.0 nM 365.43 COc1ccc(/C=N/NC(=O)CCn2cc(C)c3ccccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3910957 OBDepict O N H N N H 3 C H 3 C O O IC50 = 24.0 nM 391.47 Cc1cccc2c1c(C)cn2CCC(=O)N/N=C/c1ccc2c(c1)OCCCO2 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3965696 OBDepict O NH N N H 3 C H 3 C N IC50 = 30.0 nM 370.46 Cc1cn(CCC(=O)N/N=C/c2cc(C)c3ncccc3c2)c2ccccc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3918456 OBDepict CH 3 O O CH 3 N NH O H H F F F IC50 = 37.0 nM 392.38 COc1ccc(/C=N/NC(=O)[C@@H]2C[C@H]2c2cccc(C(F)(F)F)c2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3949870 OBDepict H 3 C O Cl O H 3 C N N H O N CH 3 CH 3 IC50 = 38.0 nM 413.91 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc(Cl)c1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3954591 OBDepict CH 3 O O CH 3 N N H O S Cl IC50 = 40.0 nM 364.85 COc1ccc(/C=N/NC(=O)CSc2cccc(Cl)c2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3964050 OBDepict CH 3 O N N N H O H H Cl IC50 = 45.0 nM 379.85 COc1cc(/C=N/NC(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3968083 OBDepict H 3 C O O N NH O N N CH 3 CH 3 IC50 = 46.0 nM 456.55 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1ccncc1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3981183 OBDepict CH 3 O O CH 3 N N H NH O Cl IC50 = 51.0 nM 361.83 COc1ccc(/C=N/NC(=O)NCCc2ccc(Cl)cc2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3968112 OBDepict CH 3 O O CH 3 N N H O N CH 3 IC50 = 51.0 nM 365.43 COc1ccc(/C=N/NC(=O)CCc2cn(C)c3ccccc23)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3914721 OBDepict H 3 C O O N NH N O N CH 3 CH 3 IC50 = 53.0 nM 456.55 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1cccnc1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3980338 OBDepict CH 3 O O CH 3 N N H O S H 3 C Cl IC50 = 55.0 nM 378.88 COc1ccc(/C=N/NC(=O)C(C)Sc2cccc(Cl)c2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3918736 OBDepict H 3 C O O N NH N N O N CH 3 CH 3 IC50 = 60.0 nM 457.53 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1cnccn1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3974283 OBDepict H 3 C O O N NH N O N CH 3 CH 3 IC50 = 66.0 nM 456.55 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1ccccn1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3971765 OBDepict H 3 C O O N NH O N CH 3 CH 3 IC50 = 80.0 nM 455.56 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1ccccc1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3944989 OBDepict CH 3 O N N N H O H H IC50 = 90.0 nM 345.4 COc1cc(/C=N/NC(=O)[C@@H]2C[C@H]2c2ccccc2)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3893648 OBDepict CH 3 O N N N H O N CH 3 IC50 = 120.0 nM 386.46 COc1ccnc2ccc(/C=N/NC(=O)CCn3cc(C)c4ccccc43)cc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3942291 OBDepict O N H N N H 3 C H 3 C N IC50 = 160.0 nM 370.46 Cc1cc(/C=N/NC(=O)CCc2cn(C)c3ccccc23)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3928377 OBDepict H 3 C O O H 3 C N N H O N IC50 = 170.0 nM 351.41 COc1ccc(/C=N/NC(=O)CCn2ccc3ccccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3965662 OBDepict H 3 C O O N NH N N O N CH 3 CH 3 IC50 = 180.0 nM 457.53 COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1cccnn1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3899989 OBDepict O HN N N CH 3 O O IC50 = 180.0 nM 377.44 Cc1cn(CCC(=O)N/N=C/c2ccc3c(c2)OCCCO3)c2ccccc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3951939 OBDepict CH 3 O O CH 3 N N H NH O IC50 = 200.0 nM 327.38 COc1ccc(/C=N/NC(=O)NCCc2ccccc2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3931655 OBDepict O N H N N H 3 C N CH 3 IC50 = 210.0 nM 370.46 Cc1cnc2ccc(/C=N/NC(=O)CCn3cc(C)c4ccccc43)cc2c1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3934816 OBDepict CH 3 N N N H O H H IC50 = 240.0 nM 329.4 Cc1cc(/C=N/NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3935046 OBDepict CH 3 O O CH 3 N N H O N CH 3 HO IC50 = 260.0 nM 395.46 COc1ccc(/C=N/NC(=O)CCn2cc(C)c3c(CO)cccc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3966655 OBDepict Cl N N N H O H H IC50 = 340.0 nM 349.82 O=C(N/N=C/c1cc(Cl)c2ncccc2c1)[C@@H]1C[C@H]1c1ccccc1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3971296 OBDepict O NH N N H 3 C N IC50 = 340.0 nM 356.43 Cc1cn(CCC(=O)N/N=C/c2ccc3ncccc3c2)c2ccccc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3928916 OBDepict O N H N N CH 3 N H 3 C IC50 = 370.0 nM 370.46 Cc1ccnc2ccc(/C=N/NC(=O)CCn3cc(C)c4ccccc43)cc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3930285 OBDepict H 3 C O N H H N H O N CH 3 N IC50 = 410.0 nM 360.42 COc1cccc([C@@H]2C[C@H]2C(=O)N/N=C/c2cc(C)c3ncccc3c2)n1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3944040 OBDepict O NH N N N H 3 C N N IC50 = 430.0 nM 358.41 Cc1cn(CCC(=O)N/N=C/c2ccc3nnccc3n2)c2ccccc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3978819 OBDepict HO O O H 3 C N N H O N CH 3 IC50 = 500.0 nM 409.49 COc1cc(/C=N/NC(=O)CCn2cc(C)c3ccccc32)ccc1OCCCO Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3955382 OBDepict O N H H N H F CH 3 N IC50 = 510.0 nM 347.39 Cc1cc(/C=N/NC(=O)[C@@H]2C[C@H]2c2ccc(F)cc2)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3969447 OBDepict F N N N H O H H IC50 = 550.0 nM 333.37 O=C(N/N=C/c1cc(F)c2ncccc2c1)[C@@H]1C[C@H]1c1ccccc1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3982510 OBDepict CH 3 O O CH 3 N N H O H H N IC50 = 610.0 nM 375.43 COc1ccc(/C=N/NC(=O)[C@@H]2C[C@H]2c2ccc3ccccc3n2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3947573 OBDepict Cl H H N H O N Cl N IC50 = 650.0 nM 384.27 O=C(N/N=C/c1cc(Cl)c2ncccc2c1)[C@@H]1C[C@H]1c1cccc(Cl)c1 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3209049 OBDepict CH 3 O O H 3 C N NH O S IC50 = 660.0 nM 330.41 COc1ccc(/C=N/NC(=O)CSc2ccccc2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3952534 OBDepict CH 3 O O CH 3 N N H O N N CH 3 IC50 = 680.0 nM 366.42 COc1ccc(/C=N/NC(=O)CCn2cc(C)c3cccnc32)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3968552 OBDepict O HN N N CH 3 O N CH 3 IC50 = 750.0 nM 376.46 Cc1cn(CCC(=O)N/N=C/c2ccc3c(c2)OCCN3C)c2ccccc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3950228 OBDepict Cl H H N H O N CH 3 N IC50 = 800.0 nM 363.85 Cc1cc(/C=N/NC(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3913484 OBDepict CH 3 O O H 3 C N NH O N IC50 = 810.0 nM 363.42 COc1ccc(/C=N/NC(=O)CCc2cnc3ccccc3c2)cc1OC Homo sapiens CHEMBL3880020 cell-based format
CHEMBL3934275 OBDepict O NH S N Cl H 3 C N IC50 = 830.0 nM 369.88 Cc1cc(/C=N/NC(=O)CSc2cccc(Cl)c2)cc2cccnc12 Homo sapiens CHEMBL3880020 cell-based format