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Q9P1W9 | PIM2_HUMAN | Serine/threonine-protein kinase pim-2 (PIM2)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3105021 OBDepict O HN N NH 2 N N F F F H H 3 C H H 2 N H HO Ki = 0.002 nM 472.47 C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O Homo sapiens CHEMBL3106178 single protein format
CHEMBL3105022 OBDepict O N H N N N F F F H H 3 C H NH 2 H HO Ki = 0.002 nM 457.46 C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O Homo sapiens CHEMBL3106178 single protein format
CHEMBL3103868 OBDepict O N H N NH 2 N N F F H H 2 N Ki = 0.004 nM 424.46 Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3106174 single protein format
CHEMBL3103869 OBDepict O N H N H 2 N N N F F H NH 2 H HO Ki = 0.006 nM 440.45 Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CC[C@@H](O)[C@H](N)C1 Homo sapiens CHEMBL3106178 single protein format
CHEMBL3902148 OBDepict F N N H O N NH H 3 C O NH H CH 3 H 3 C CH 3 H 3 C IC50 = 0.012 nM 383.43 C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3940091 OBDepict O N H H CH 3 N H N N H N O H 3 C CH 3 H 3 C H 3 C H 3 C IC50 = 0.012 nM 393.49 CC(C)n1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL4741714 OBDepict O N H N F H F F H H 3 C H NH 2 IC50 = 0.018 nM 439.48 C[C@@H]1C[C@H](N)C[C@H](c2ccccc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 Homo sapiens CHEMBL4687900 single protein format
CHEMBL3651966 OBDepict O N H N N F H F F H H 3 C H NH 2 Ki = 0.018 nM 440.47 C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 Homo sapiens CHEMBL3750380 single protein format
CHEMBL3909351 OBDepict H 2 N H N H N O H N N H N O H 3 C H 3 C CH 3 H 3 C IC50 = 0.02 nM 394.48 Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](CCN)NC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL2387464 OBDepict O N H N N N N NH H N H F H F N H Ki = 0.032 nM 502.53 O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 Homo sapiens CHEMBL2387969 single protein format
CHEMBL3949102 OBDepict CH 3 N N N H CH 3 F N H O N H IC50 = 0.0354 nM 377.42 Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1(C)CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3903686 OBDepict CH 3 N N N H H N H H 2 N H O N H H CH 3 IC50 = 0.0358 nM 390.49 Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](N)C1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL2387465 OBDepict O N H N N N N NH H N H F F H F N H Ki = 0.037 nM 520.52 O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 Homo sapiens CHEMBL2387969 single protein format
CHEMBL3895124 OBDepict CH 3 N N NH O CH 3 F N H O NH H CH 3 IC50 = 0.0378 nM 395.44 CCn1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL3918907 OBDepict O N H N H N N NH H O H 3 C CH 3 H 3 C IC50 = 0.0378 nM 351.41 CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2[nH]c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL3623150 OBDepict O N H N NH 2 S N N N CH 3 F F F F H NH 2 Ki = 0.04 nM 483.5 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL4459538 OBDepict CH 3 O H N H NH 2 N N H CH 3 N O N NH 2 S F F Ki = 0.04 nM 477.54 CO[C@H]1C[C@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL3949318 OBDepict F N N N H N H CH 3 O NH H CH 3 H 3 C IC50 = 0.0484 nM 365.41 Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC1(C)CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3634783 OBDepict CH 3 N N N N N H N N HN Ki = 0.049 nM 372.44 Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)n1 Homo sapiens CHEMBL3636741 single protein format
CHEMBL3676285 OBDepict O N H N NH 2 S N N F F H H 2 N Ki = 0.05 nM 430.48 Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL4568404 OBDepict O NH H CH 3 N H N N H N O CH 3 CH 3 IC50 = 0.05 nM 403.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5(C)CC5)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3808669 OBDepict O N H N H H N N N H CH 3 IC50 = 0.05 nM 347.42 Cc1nc2cccc3c2nc1NCCCC[C@H]1CNC(=O)c2cc-3[nH]c21 Homo sapiens CHEMBL3812018 assay format
CHEMBL4439756 OBDepict F N H 2 N N N H CH 3 N O N NH 2 S F F Ki = 0.05 nM 465.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)C1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL3808887 OBDepict O N H N H H N N H H 3 C N H CH 3 IC50 = 0.05 nM 359.43 Cc1nc2cccc3c2nc1N[C@H](C)/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 Homo sapiens CHEMBL3812018 assay format
CHEMBL3949175 OBDepict F N N H N HN O N H H CH 3 CH 3 IC50 = 0.06 nM 393.47 C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c3N=C(NC3(C)CC3)N(C3CC3)C4)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3896195 OBDepict F N N N H NH CH 3 O N H 3 C CH 3 H 3 C H IC50 = 0.0667 nM 365.41 Cc1nc2ccc(F)c(-c3cc4c(=O)[nH]ccc4[nH]3)c2nc1NC(C)(C)C Homo sapiens CHEMBL3888800 single protein format
CHEMBL3810121 OBDepict O N H N H H N N N H CH 3 IC50 = 0.07 nM 345.41 Cc1nc2cccc3c2nc1NC/C=CC[C@H]1CNC(=O)c2cc-3[nH]c21 Homo sapiens CHEMBL3812018 assay format
CHEMBL3960373 OBDepict H 3 C N N HN O H 3 C H 3 C CH 3 F N H O N H H CH 3 IC50 = 0.0741 nM 397.45 CCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL2387471 OBDepict O N H N N N N NH H N F F HN Ki = 0.076 nM 502.53 O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 Homo sapiens CHEMBL2387969 single protein format
CHEMBL3919725 OBDepict O NH H H 3 C N H N N H N O CH 3 CH 3 CH 3 IC50 = 0.076 nM 391.48 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3932475 OBDepict CH 3 N N N N N N N H H 2 N Ki = 0.077 nM 426.53 Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 Homo sapiens CHEMBL3889102 assay format
CHEMBL3909217 OBDepict H 3 C N N HN O H 3 C H 3 C CH 3 N H O N H H CH 3 IC50 = 0.077 nM 379.46 CCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL3933056 OBDepict CH 3 N N HN CH 3 N Cl H O HN IC50 = 0.0783 nM 367.84 Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)NC4)c2nc1NC1(C)CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3966732 OBDepict F F N N N N H N N H H 3 C H H 2 N H HO IC50 = 0.08 nM 451.48 C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H](N)[C@@H]1O Homo sapiens CHEMBL3887609 single protein format
CHEMBL4441708 OBDepict O N H H CH 3 N H N N H N O CH 3 CH 3 H 3 C IC50 = 0.08 nM 405.5 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5CC5)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3808662 OBDepict H 3 C HN H N HN N H 3 C N H O IC50 = 0.08 nM 359.43 C/C1=CC[C@H]2CNC(=O)c3cc([nH]c32)-c2cccc3nc(C)c(nc23)NC1 Homo sapiens CHEMBL3812018 assay format
CHEMBL3634760 OBDepict CH 3 N N N N N H N N H 3 C H H 2 N Ki = 0.088 nM 388.48 Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3636741 single protein format
CHEMBL3950251 OBDepict F F N N N N H N N H H 2 N H H 2 N H HO IC50 = 0.09 nM 452.47 N[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H](N)[C@@H]1O Homo sapiens CHEMBL3864806 single protein format
CHEMBL2387463 OBDepict O N H N N N N NH H N F HN Ki = 0.094 nM 484.54 O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 Homo sapiens CHEMBL2387969 single protein format
CHEMBL3942186 OBDepict F F N N N N H N N H H 3 C H H 2 N IC50 = 0.094 nM 435.48 C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 Homo sapiens CHEMBL3864806 single protein format
CHEMBL4437940 OBDepict O N H N NH 2 S N N N CH 3 F F H H 2 N Ki = 0.1 nM 447.52 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N)CC1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL3648680 OBDepict O N H N NH 2 S N N N CH 3 F F H F H NH 2 Ki = 0.1 nM 465.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL4110951 OBDepict O HN F N N N N H N N H H 3 C H NH 2 IC50 = 0.1 nM 500.58 C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4cc(C(=O)NC5CC5)ccc4F)nn23)C1 Homo sapiens CHEMBL3887609 single protein format
CHEMBL3930148 OBDepict F N N N N H N N H H 3 C H H 2 N IC50 = 0.1 nM 417.49 C[C@H]1C[C@@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ccccc4F)nn23)C1 Homo sapiens CHEMBL3887609 single protein format
CHEMBL3965946 OBDepict F F N N N N H N N H H 3 C H H 2 N IC50 = 0.1 nM 435.48 C[C@H]1C[C@@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 Homo sapiens CHEMBL3887609 single protein format
CHEMBL3901766 OBDepict H 3 C N CH 3 CH 3 CH 3 N N N H O NH IC50 = 0.1 nM 363.47 CCN(c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C Homo sapiens CHEMBL3888800 single protein format
CHEMBL3958862 OBDepict O NH H H 3 C N H N N H N O H 3 C IC50 = 0.1 nM 389.46 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3918273 OBDepict O N H H CH 3 N H N N H N O H 3 C H H H 2 N IC50 = 0.1 nM 406.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N[C@H]5CCC[C@@H](N)C5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3941050 OBDepict F N N H O N N H H 3 C O NH H CH 3 H 3 C IC50 = 0.1 nM 381.41 C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3944421 OBDepict F N N H O N N H O HN H H 3 C CH 3 IC50 = 0.1 nM 421.48 C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C5CC5)c(NC5(C)CCC5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3979182 OBDepict F N N N H NH CH 3 O HN H H 3 C H 3 C CH 3 H 3 C IC50 = 0.109 nM 367.43 Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)C Homo sapiens CHEMBL3888800 single protein format
CHEMBL3978766 OBDepict CH 3 N N N N N H N N HN Ki = 0.11 nM 386.46 Cc1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)n1 Homo sapiens CHEMBL4052120 single protein format
CHEMBL4471849 OBDepict H 3 C N N N CH 3 N HN O CH 3 N H O N H H CH 3 IC50 = 0.11 nM 457.54 CC(c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O Homo sapiens CHEMBL4370146 single protein format
CHEMBL3919616 OBDepict HO N N N H O CH 3 CH 3 H 3 C N H O N H H H 3 C IC50 = 0.11 nM 409.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CCCO)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3961823 OBDepict CH 3 N N N N N N N F F F H NH 2 Ki = 0.115 nM 454.46 Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCC[C@H](N)C3)n2)n1 Homo sapiens CHEMBL3889102 assay format
CHEMBL4436404 OBDepict O N H H CH 3 N H N N H N O CH 3 IC50 = 0.12 nM 403.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5CC5)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3634771 OBDepict N N N N N N H N N HN Ki = 0.127 nM 385.44 N#CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 Homo sapiens CHEMBL3636741 single protein format
CHEMBL4461181 OBDepict O N H H CH 3 N H N N H N O H 3 C CH 3 H 3 C H O IC50 = 0.13 nM 435.53 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@H]5CCCO5)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3968854 OBDepict O N H H H 3 C N H N HN N O H 3 C CH 3 IC50 = 0.13 nM 377.45 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3914639 OBDepict CH 3 O N N N N H H 2 N N N N CH 3 Ki = 0.134 nM 416.49 COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL3889102 assay format
CHEMBL3957722 OBDepict F N N N H N H CH 3 O N H H 3 C IC50 = 0.136 nM 379.44 Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3982539 OBDepict CH 3 N N N N N N N H 3 C H NH 2 Ki = 0.142 nM 400.49 Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3CCC[C@H](N)C3)n2)n1 Homo sapiens CHEMBL3889102 assay format
CHEMBL3634769 OBDepict CH 3 N N O N N N H N N HN Ki = 0.145 nM 402.46 CCn1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1=O Homo sapiens CHEMBL3636741 single protein format
CHEMBL4450494 OBDepict H 3 C N N N H 3 C H N HN O CH 3 N H O N H H CH 3 IC50 = 0.15 nM 457.54 C[C@@H](c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O Homo sapiens CHEMBL4370146 single protein format
CHEMBL2048872 OBDepict O HN S O N H NH 2 Ki = 0.16 nM 379.49 N[C@@H]1CCCN(c2c(/C=C3SC(=O)NC3=O)cccc2-c2ccccc2)C1 Homo sapiens CHEMBL3106178 single protein format
CHEMBL4513589 OBDepict O N H H CH 3 N H N NH N O CH 3 NH 2 IC50 = 0.16 nM 418.5 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(N)CC5)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3910446 OBDepict HO H 2 N H N H O H H N H N H 3 C N N H O N H H H 3 C IC50 = 0.16 nM 477.57 Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NC(=O)[C@H](N)CO)C1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL4563904 OBDepict CH 3 N N N N HN O CH 3 H 3 C CH 3 N H O HN H H 3 C IC50 = 0.16 nM 445.53 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(Cc5cn(C)cn5)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL4456165 OBDepict O NH H CH 3 N H N N H N O CH 3 CH 3 CH 3 CH 3 IC50 = 0.16 nM 405.5 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5(C)CC5)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3890727 OBDepict F N N N H NH CH 3 O N H CH 3 IC50 = 0.162 nM 365.41 Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3652638 OBDepict O N H N NH 2 S N N N CH 3 F F H H 2 N Ki = 0.167 nM 447.52 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@@H](N)CC1 Homo sapiens CHEMBL3707982 assay format
CHEMBL3890346 OBDepict O N H N H N HN N O CH 3 CH 3 H 3 C CH 3 IC50 = 0.169 nM 365.44 Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL3634767 OBDepict CH 3 N N N N N H N N HN Ki = 0.17 nM 374.45 Cn1cc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 Homo sapiens CHEMBL3636741 single protein format
CHEMBL2387474 OBDepict O N H N N N N H N F F HN Ki = 0.17 nM 501.54 O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(CCC3CCNCC3)nc12 Homo sapiens CHEMBL2387969 single protein format
CHEMBL3942145 OBDepict OH H NH N O H N N NH H 3 C IC50 = 0.177 nM 349.39 Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CO)NC4=O)c2nc1NC1CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL4470271 OBDepict O NH H CH 3 N H N NH N O CH 3 IC50 = 0.18 nM 403.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCC5)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL4446411 OBDepict O N H H CH 3 N H N NH N O CH 3 OH IC50 = 0.18 nM 419.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(O)CC5)c(NC5(C)CC5)nc34)[nH]c21 Homo sapiens CHEMBL4370146 single protein format
CHEMBL3896244 OBDepict F F N N N N H N N H H 2 N H H 3 C IC50 = 0.18 nM 435.48 C[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1N Homo sapiens CHEMBL3864806 single protein format
CHEMBL3903402 OBDepict CH 3 N N NH CH 3 N H O N H H CH 3 IC50 = 0.183 nM 347.42 Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC1(C)CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3930816 OBDepict CH 3 N N N N N N H NH 2 Ki = 0.187 nM 439.57 CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)c1 Homo sapiens CHEMBL3889102 assay format
CHEMBL3924828 OBDepict O N H H CH 3 N H N N H N O H 3 C CH 3 H 3 C F F F IC50 = 0.19 nM 433.43 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC(F)(F)F)c(NC(C)(C)C)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3947143 OBDepict H 3 C O N N HN O H 3 C H 3 C CH 3 N H O N H H CH 3 IC50 = 0.193 nM 409.49 COCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL3897988 OBDepict O N H N H N N H N O H 3 C H 3 C CH 3 H 3 C IC50 = 0.193 nM 351.41 Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CNC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format
CHEMBL3914535 OBDepict CH 3 N N HN CH 3 H 3 C CH 3 N H O HN IC50 = 0.195 nM 363.47 CCc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C Homo sapiens CHEMBL3888800 single protein format
CHEMBL3103867 OBDepict O N H N NH 2 N N F H H 2 N Ki = 0.2 nM 406.47 Nc1ccc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL3956349 OBDepict H N N N N N N H NH 2 Ki = 0.2 nM 371.45 N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 Homo sapiens CHEMBL4052120 single protein format
CHEMBL4453890 OBDepict O N H N NH 2 S N N N CH 3 F F H OH H H 2 N Ki = 0.2 nM 463.51 Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](O)[C@H](N)CC1 Homo sapiens CHEMBL4317000 single protein format
CHEMBL3648724 OBDepict CH 3 O H H NH 2 N N N H CH 3 N O N NH 2 S F F Ki = 0.2 nM 477.54 CO[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N Homo sapiens CHEMBL4317000 single protein format
CHEMBL3984961 OBDepict CH 3 N H CH 3 N N O F N H O NH H CH 3 IC50 = 0.2 nM 395.44 CC(C)Nc1nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c(=O)n1C1CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3809940 OBDepict H 3 C HN H N HN N H 3 C N H O IC50 = 0.2 nM 359.43 C/C1=C/C[C@H]2CNC(=O)c3cc([nH]c32)-c2cccc3nc(C)c(nc23)NC1 Homo sapiens CHEMBL3812018 assay format
CHEMBL3958307 OBDepict CH 3 N N HN H N H H 2 N H O HN IC50 = 0.2 nM 390.49 Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CCC[C@H](N)C1 Homo sapiens CHEMBL3888798 single protein format
CHEMBL3808942 OBDepict O N H N H H N N N H CH 3 IC50 = 0.2 nM 347.42 Cc1nc2cccc3c2nc1NCCCC[C@@H]1CNC(=O)c2cc-3[nH]c21 Homo sapiens CHEMBL3812018 assay format
CHEMBL3896782 OBDepict F N N H O N N H CH 3 O HN H H 3 C CH 3 IC50 = 0.2 nM 395.44 C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3810095 OBDepict O N H N H H N N H H 3 C N H CH 3 IC50 = 0.2 nM 361.45 Cc1nc2cccc3c2nc1N[C@H](C)CCC[C@H]1CNC(=O)c2cc-3[nH]c21 Homo sapiens CHEMBL3812018 assay format
CHEMBL3911461 OBDepict O NH H H 3 C N H N N H N O CH 3 IC50 = 0.2 nM 403.49 C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC5(C)CCC5)nc34)[nH]c21 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3979954 OBDepict CH 3 N N NH CH 3 N H O N H H CH 3 IC50 = 0.201 nM 347.42 Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC1(C)CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3940707 OBDepict F N N N H NH CH 3 O HN H H 3 C H 3 C CH 3 H 3 C IC50 = 0.201 nM 367.43 Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC(C)(C)C Homo sapiens CHEMBL3888800 single protein format
CHEMBL3976267 OBDepict NH 2 N H 3 C N N N N N N CH 3 Ki = 0.204 nM 400.49 Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(N)CCC3C)n2)n1 Homo sapiens CHEMBL3889102 assay format
CHEMBL3905144 OBDepict OH NH N O H N N NH H 3 C IC50 = 0.212 nM 349.39 Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC1CC1 Homo sapiens CHEMBL3888800 single protein format
CHEMBL3919362 OBDepict H 3 C O N N HN O H 3 C H 3 C CH 3 N H O N H IC50 = 0.218 nM 395.46 COCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CNC4=O)cccc2c1=O Homo sapiens CHEMBL3888800 single protein format