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Q9P2K8 | E2AK4_HUMAN | eIF-2-alpha kinase GCN2 (EIF2AK4)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -5100.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804385 cell-based format
CHEMBL3407849 OBDepict H 3 C NH N N O H 3 C O N O N CH 3 IC50 = 5.0 nM 541.61 CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3C)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407851 OBDepict H 3 C NH N N O Cl O N O N CH 3 IC50 = 10.0 nM 562.03 CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3Cl)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407850 OBDepict H 3 C NH N N O H 2 N O N O N CH 3 IC50 = 12.0 nM 542.6 CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3N)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407852 OBDepict H 3 C N H N N F O H 3 C NH 2 O N O N CH 3 IC50 = 36.0 nM 574.62 CNc1ncc2c(F)cc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407504 OBDepict H 3 C N H N N O H 3 C NH 2 O N O N CH 3 IC50 = 42.0 nM 556.63 CNc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407853 OBDepict H 3 C N H N N Cl O H 3 C NH 2 O N O N CH 3 IC50 = 42.0 nM 591.07 CNc1ncc2c(Cl)cc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407857 OBDepict CH 3 N H N S CH 3 NH 2 O N O N H 3 C IC50 = 97.0 nM 545.67 CNc1nc2ccc(-c3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2s1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407858 OBDepict NH 2 N S CH 3 NH 2 O N O N H 3 C IC50 = 100.0 nM 531.64 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(N)sc2c1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407854 OBDepict CH 3 N N O CH 3 NH 2 O N O N H 3 C IC50 = 240.0 nM 541.61 Cc1ncc2ccc(Oc3c(C)ccc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)c3N)cc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407848 OBDepict CH 3 O O CH 3 O N N N H O N O N H 3 C IC50 = 290.0 nM 573.61 COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC Homo sapiens CHEMBL3412167 assay format
CHEMBL3260331 OBDepict Cl F N N N N N N H N N H H OH IC50 < 300.0 nM 428.86 O[C@H]1CC[C@H](n2ccc(Nc3ncc4c(nnn4-c4ccc(Cl)c(F)c4)n3)n2)CC1 Homo sapiens CHEMBL3271322 cell-based format
CHEMBL3260332 OBDepict CH 3 O N N N N N N H N N N H IC50 < 300.0 nM 447.55 CCOc1ccc(-n2nnc3nc(Nc4ccn(CCCC5CCNCC5)n4)ncc32)cc1 Homo sapiens CHEMBL3271322 cell-based format
CHEMBL4205481 OBDepict H 3 C N N N N N N N H N H OH O CH 3 CH 3 IC50 = 300.0 nM 404.43 CC(C)C1(O)C(=O)Nc2cc(Nc3nc4c(-c5cnn(C)c5)nccn4n3)ccc21 Homo sapiens CHEMBL4184944 single protein format
CHEMBL4207945 OBDepict Cl F N N N N N N H N N H H OH IC50 < 300.0 nM 428.86 O[C@H]1CC[C@H](n2cc(Nc3ncc4nnn(-c5ccc(Cl)c(F)c5)c4n3)cn2)CC1 Homo sapiens CHEMBL4184944 single protein format
CHEMBL3260330 OBDepict H N N N N N N N N H N N O IC50 < 300.0 nM 402.42 c1cc2cn[nH]c2cc1-n1nnc2nc(Nc3ccn(C4CCOCC4)n3)ncc21 Homo sapiens CHEMBL3271322 cell-based format
CHEMBL3260333 OBDepict HO O CH 3 H 3 C N N N N N N H N N H 3 C IC50 = 300.0 nM 408.47 CCn1ccc(Nc2ncc3c(nnn3-c3ccc(C(C)(C)OCCO)cc3)n2)n1 Homo sapiens CHEMBL3271322 cell-based format
CHEMBL3407859 OBDepict F N S CH 3 H 2 N O N O N CH 3 IC50 = 310.0 nM 548.64 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(CF)sc2c1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3407847 OBDepict CH 3 N H N N CH 3 NH 2 NH O O F F F H 3 C IC50 = 420.0 nM 481.48 CNc1ncc2cc(-c3c(C)ccc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)c3N)ccc2n1 Homo sapiens CHEMBL3412167 assay format
CHEMBL3577124 OBDepict CH 3 N H N N N H 3 C CH 3 NH F N H O H 3 C CH 3 H 3 C IC50 = 450.0 nM 424.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 Homo sapiens CHEMBL3578901 cell-based format
CHEMBL3407860 OBDepict H 3 C NH 2 O S N N O N CH 3 F F IC50 = 610.0 nM 566.63 Cc1ccc(C(=O)c2c(-c3ccccc3)n(C)n(-c3ccccc3)c2=O)c(N)c1-c1ccc2nc(C(F)F)sc2c1 Homo sapiens CHEMBL3412167 assay format
CHEMBL2441342 OBDepict O N N F F F F N CH 3 H 2 N N N IC50 = 776.0 nM 470.43 Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 Homo sapiens CHEMBL2443945 single protein format