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Q9UHC9 | NPCL1_HUMAN | NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

3D structures mapped by conservation among orthologs

[ Domain: "Frizzled cysteine-rich domain-related" // NPC1_N ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL578401 OBDepict F OH H H O N H T T O H O H HO H H OH O OH H OH IC50 = 150.0 nM 571.58 [3H]c1cc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccccc2[3H])ccc1O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL1046285 assay format
CHEMBL321017 OBDepict F N O H H OH H O H O H OH F H H OH O HO H OH IC50 = 300.0 nM 585.56 O=C(O)[C@H]1O[C@@H](Oc2ccc([C@@H]3[C@@H](CC[C@H](O)c4ccc(F)cc4)C(=O)N3c3ccc(F)cc3)cc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL970539 cell-based format
CHEMBL466245 OBDepict O N N O IC50 = 390.0 nM 526.68 O=C(c1cccc2ccccc12)N1CC(C(=O)N2CCC3(C=Cc4ccccc43)CC2)CC(c2ccccc2)C1 Homo sapiens CHEMBL970539 cell-based format
CHEMBL466849 OBDepict O N H H N O IC50 = 660.0 nM 462.59 O=C([C@@H]1C[C@@H](c2ccccc2)CN1C(=O)c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 Homo sapiens CHEMBL970539 cell-based format
CHEMBL1629892 OBDepict HO N H O N N O N O CH 3 CH 3 CH 3 IC50 = 1000.0 nM 492.62 CC(C)(C)c1ccc(C(=O)N2CCC3(CC2)C(=O)N(CC(=O)NCCO)CN3c2ccccc2)cc1 Homo sapiens CHEMBL1638622 cell-based format