Q9UHI8 | ATS1_HUMAN | A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)
3D structures mapped by conservation among orthologs
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Reprolysin ]
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[ Domain: "Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins" // KOG3538_1st ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
Ki table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL187092 | IC50 | = | 79.0 | nM | 472.92 | C[C@@]1(O)CCCN(S(=O)(=O)c2ccc(OCc3ccc(F)cc3Cl)cc2)[C@H]1C(=O)NO | Homo sapiens | CHEMBL2167995 | single protein format | |
| CHEMBL4877087 | IC50 | = | 328.0 | nM | 390.87 | O=C1NC(=O)C(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)(C2CC2)N1 | Homo sapiens | CHEMBL4835174 | single protein format | |
| CHEMBL4862188 | IC50 | = | 631.0 | nM | 445.88 | O=C1NC(=O)C(CCC(=O)N2CCN(c3ccc(F)c(Cl)c3)CC2)(c2ccccn2)N1 | Homo sapiens | CHEMBL4835174 | single protein format | |
| CHEMBL208009 | Ki | = | 776.0 | nM | 448.52 | Cc1cc(COc2ccc(C(=O)NC3(CC(=O)NO)CCNCC3)cc2)c2ccccc2n1 | Homo sapiens | CHEMBL853110 | single protein format |