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Q9UIQ6 | LCAP_HUMAN | Leucyl-cystinyl aminopeptidase (LNPEP)

3D structures mapped by conservation among orthologs

[ Domain: "ARM repeat" // ERAP1_C_1 ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // KOG1046 ]

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[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1 ]

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[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1782887 OBDepict O NH H HN H N H O O H NH 2 OH O HO Ki = 1.8 nM 536.63 N[C@H]1CC/C=C/CC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL4101200 OBDepict CH H NH O P O OH H NH 2 H O NH 2 IC50 = 2.0 nM 455.5 C#CC[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL4095882 OBDepict HO N O H N H O P O OH H NH 2 H O NH 2 IC50 = 4.0 nM 590.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccc(O)cc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1782881 OBDepict OH O N H O H NH O H N H O H NH 2 HO Ki = 4.1 nM 536.63 N[C@H]1CCCC/C=C/C[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL4077855 OBDepict OH N O H N H O P O OH H NH 2 H O NH 2 IC50 = 9.0 nM 590.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2O)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1277811 OBDepict O NH H HN H N H O O S H NH 2 S OH O HO Ki = 10.0 nM 574.73 N[C@H]1CCSSCC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL4089555 OBDepict H 3 C H 3 C H N O P O OH H NH 2 H O NH 2 IC50 = 14.0 nM 423.49 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL4069576 OBDepict CH 3 H 3 C NH H O NH 2 O H P O OH H 2 N H IC50 = 16.0 nM 563.68 CC(C)C[C@H](NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL4065841 OBDepict O NH H P H O OH O NH 2 NH 2 H Ki = 18.0 nM 597.7 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4011377 cell-based format
CHEMBL4069425 OBDepict O N H H P H O OH O O NH 2 NH 2 H N IC50 = 18.0 nM 574.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1277437 OBDepict CH 3 O O NH O O CH 3 N HO Ki = 20.0 nM 404.42 CCOC(=O)C1=C(NC(C)=O)Oc2cc(O)ccc2C1c1cnc2ccccc2c1 Homo sapiens CHEMBL1286215 cell-based format
CHEMBL1277718 OBDepict O NH H HN H S NH O O S H H 2 N HO Ki = 22.5 nM 502.66 N[C@H]1CCSSC[C@@H](C(=O)NCc2ccccc2)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL1782882 OBDepict OH O N H O H NH O H N H O H NH 2 HO Ki = 25.0 nM 538.65 N[C@H]1CCCCCCC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL1277438 OBDepict HO O N H O H N H S O S H HN O H H 2 N HO Ki = 25.3 nM 560.7 N[C@@H]1CCSSCC[C@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL4097268 OBDepict CH 3 H 3 C H NH O P O OH H NH 2 H O H 2 N HO IC50 = 29.0 nM 489.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL3416733 OBDepict H 3 C H 3 C H HN O P O OH H NH 2 H O NH 2 N H IC50 = 30.0 nM 512.59 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O Homo sapiens CHEMBL3419982 cell-based format
CHEMBL1782888 OBDepict O NH H HN H HN N H O O H NH 2 OH O HO Ki = 30.4 nM 537.62 N[C@H]1CC/C=CCN[C@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL4065841 OBDepict O NH H P H O OH O NH 2 NH 2 H IC50 = 32.0 nM 597.7 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL4081682 OBDepict CH 3 CH 3 H NH O P O OH H NH 2 H O NH 2 H 3 C H 3 C IC50 = 32.0 nM 439.54 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1277893 OBDepict O NH H HN H N H O O S H NH 2 S OH O HO Ki = 34.9 nM 574.73 N[C@H]1CCSSCC[C@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL1277623 OBDepict O NH H HN H S NH O O S H H 2 N HO O HO Ki = 35.1 nM 560.7 N[C@H]1CCSSC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL4099693 OBDepict CH 3 H 3 C H NH O P O OH H NH 2 H O H 2 N IC50 = 41.0 nM 473.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1782886 OBDepict HO O N H O H N H O H HN O H H 2 N HO Ki = 41.1 nM 522.6 N[C@H]1CC/C=CCC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL4074464 OBDepict O N H H P H O OH O H 2 N NH 2 H IC50 = 46.0 nM 565.69 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1782885 OBDepict HO O N H O H N H O H HN O H H 2 N HO Ki = 50.0 nM 522.6 N[C@H]1CC/C=C/CC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL286500 OBDepict H 3 C H 3 C N H N H O O H O OH CH 3 H 3 C N H O HO Ki = 52.0 nM 435.52 CCC(C)C(NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(=O)NC(C(=O)O)C(C)C Homo sapiens CHEMBL706597 single protein format
CHEMBL1277531 OBDepict O N H H HN S O S H N H O H NH 2 OH Ki = 54.8 nM 502.66 N[C@H]1CCSSCC[C@@H](C(=O)NCc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL1782883 OBDepict HO O N H O H N H O H HN O H H 2 N HO Ki = 64.2 nM 524.62 N[C@H]1CCCCCC[C@@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL4091951 OBDepict CH 3 CH 3 H NH O P O OH H 3 C H NH 2 H O H 2 N IC50 = 102.0 nM 397.46 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](C)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL3416692 OBDepict CH 3 NH 2 H N H O H 2 N HN O H O O N H IC50 = 105.0 nM 541.65 CCCC[C@H](N)C(=O)Nc1cc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)ccc1N Homo sapiens CHEMBL3419982 cell-based format
CHEMBL4077711 OBDepict CH 3 H 3 C H NH O P O OH H NH 2 H O H 2 N IC50 = 185.0 nM 473.55 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1782884 OBDepict O N H H HN O H N H O H NH 2 OH Ki = 193.0 nM 466.58 N[C@H]1CCCCCC[C@@H](C(=O)NCc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL4096799 OBDepict O NH H P H O OH O NH 2 NH 2 H IC50 = 221.0 nM 597.7 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1277717 OBDepict O NH H HN H S NH O O S H H 2 N HO O HO Ki = 242.0 nM 560.7 N[C@H]1CCSSC[C@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286215 cell-based format
CHEMBL1277530 OBDepict HO O N H O H N H S O S H HN O H H 2 N HO Ki = 282.0 nM 560.7 N[C@H]1CCSSCC[C@H](C(=O)NCc2ccccc2CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286215 cell-based format
CHEMBL3416693 OBDepict CH 3 NH 2 H N H O NH 2 NH O H O HO N H IC50 = 296.0 nM 451.53 CCCC[C@H](N)C(=O)Nc1cc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)ccc1N Homo sapiens CHEMBL3419982 cell-based format
CHEMBL1782890 OBDepict O N H H HN O H N H O H NH 2 Ki = 351.0 nM 448.57 N[C@H]1CC/C=CCC[C@@H](C(=O)NCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL3125960 OBDepict CH 3 O O H 2 N O N OH Ki = 360.0 nM 362.39 CCOC(=O)C1=C(N)Oc2cc(O)ccc2C1c1cnc2ccccc2c1 Homo sapiens CHEMBL3130959 cell-based format
CHEMBL4066723 OBDepict H 3 C H 3 C H HN O P O OH H NH 2 H O NH 2 N N H IC50 = 381.0 nM 463.52 CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O Homo sapiens CHEMBL4024807 cell-based format
CHEMBL4096656 OBDepict O N H H P H O OH O O NH 2 NH 2 H N IC50 = 434.0 nM 574.62 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL3416726 OBDepict H 3 C H 2 N H HN O H 2 N N H O H O O N H IC50 = 438.0 nM 541.65 CCCC[C@H](N)C(=O)Nc1ccc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)cc1N Homo sapiens CHEMBL3419982 cell-based format
CHEMBL3125936 OBDepict CH 3 O O NH O O CH 3 N HO Ki = 480.0 nM 354.36 CCOC(=O)C1=C(NC(C)=O)Oc2cc(O)ccc2C1c1cccnc1 Homo sapiens CHEMBL3130959 cell-based format
CHEMBL4093454 OBDepict O N H H P H O OH O H 2 N NH 2 H IC50 = 561.0 nM 565.7 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC12CC3CC(CC(C3)C1)C2)CP(=O)(O)[C@@H](N)CCc1ccccc1 Homo sapiens CHEMBL4024807 cell-based format
CHEMBL1277810 OBDepict O NH H HN H S NH O O S H H 2 N HO N Ki = 633.0 nM 503.65 N[C@H]1CCSSC[C@@H](C(=O)NCc2cccnc2)NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O Homo sapiens CHEMBL1286213 cell-based format
CHEMBL3416697 OBDepict H 2 N NH NH NH 2 H N H O NH 2 NH O H O HO N H IC50 = 655.0 nM 494.56 N=C(N)NCCC[C@H](N)C(=O)Nc1cc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)ccc1N Homo sapiens CHEMBL3419982 cell-based format
CHEMBL1782889 OBDepict O N H H HN O H N H O H NH 2 Ki = 697.0 nM 448.57 N[C@H]1CC/C=C/CC[C@@H](C(=O)NCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O Homo sapiens CHEMBL1787846 cell-based format
CHEMBL3125942 OBDepict CH 3 O O NH 2 O N HO Ki = 900.0 nM 362.39 CCOC(=O)C1=C(N)Oc2cc(O)ccc2C1c1ccnc2ccccc12 Homo sapiens CHEMBL3130959 cell-based format
CHEMBL3416696 OBDepict CH 3 O O N H H O HN OH H 2 N O NH 2 H N H NH H 2 N IC50 = 966.0 nM 485.55 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCCNC(=N)N)c1 Homo sapiens CHEMBL3419982 cell-based format