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Q9UK32 | KS6A6_HUMAN | Ribosomal protein S6 kinase alpha-6 (RPS6KA6)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 0.159 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328598 single protein format
CHEMBL4543618 OBDepict CH 3 O H 3 C N N N N H N H N N CH 3 H N O F F F IC50 = 7.0 nM 568.6 CC(C)Oc1cncnc1-c1ccc2nc(Nc3cc([C@@H](C)N4CCN(C(=O)CC(F)(F)F)CC4)ccn3)[nH]c2c1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4847762 OBDepict CH 3 H 3 C O O N N N NH F F HO IC50 = 9.5 nM 404.42 CC(C)C1OC(=O)N(C2CCCC2)c2nc(Nc3cc(F)c(O)c(F)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4847469 OBDepict H 3 C CH 3 O O N N N NH F F HO IC50 = 12.0 nM 418.44 CC(C)C1OC(=O)N(C2CCCCC2)c2nc(Nc3cc(F)c(O)c(F)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4846725 OBDepict CH 3 O CH 3 O N N N NH F F HO IC50 = 12.0 nM 432.47 CCC(CC)C1OC(=O)N(C2CCCC2)c2nc(Nc3cc(F)c(O)c(F)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL573107 OBDepict H 3 C CH 3 N H 3 C N O N CH 3 N N H F F OH IC50 = 15.0 nM 391.42 CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C Homo sapiens CHEMBL4623002 single protein format
CHEMBL4870231 OBDepict CH 3 N O O N N N H CH 3 CH 3 F F HO IC50 = 15.0 nM 432.47 CC1CCCC(N2C(=O)OC(C(C)C)c3cnc(Nc4cc(F)c(O)c(F)c4)nc32)C1 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4870807 OBDepict CH 3 CH 3 N O O N N N H CH 3 H 3 C F F OH IC50 = 15.5 nM 406.43 CC(C)CCN1C(=O)OC(C(C)C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4846978 OBDepict CH 3 H 3 C O O N N N NH F HO IC50 = 18.0 nM 386.43 CC(C)C1OC(=O)N(C2CCCC2)c2nc(Nc3ccc(O)c(F)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL2064666 OBDepict CH 3 O HN N N H N HN Cl H O H H O H 2 N H IC50 = 19.0 nM 539.08 COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 Homo sapiens CHEMBL2067599 single protein format
CHEMBL4845942 OBDepict H 3 C CH 3 O O N N N HN F F OH IC50 = 25.0 nM 390.39 CC(C)C1OC(=O)N(C2CCC2)c2nc(Nc3cc(F)c(O)c(F)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4872665 OBDepict CH 3 N O O N N NH H 3 C CH 3 F F HO IC50 = 28.5 nM 432.47 CC1CCC(N2C(=O)OC(C(C)C)c3cnc(Nc4cc(F)c(O)c(F)c4)nc32)CC1 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4852908 OBDepict CH 3 H 3 C O O N N N NH Cl HO IC50 = 33.0 nM 402.88 CC(C)C1OC(=O)N(C2CCCC2)c2nc(Nc3ccc(O)c(Cl)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4850890 OBDepict CH 3 H 3 C O O N N N NH O F F HO IC50 = 54.9 nM 406.39 CC(C)C1OC(=O)N(C2CCOC2)c2nc(Nc3cc(F)c(O)c(F)c3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4856762 OBDepict H 3 C CH 3 N O O N N N H CH 3 CH 3 HO IC50 = 84.0 nM 370.45 CC(C)CCN1C(=O)OC(C(C)C)c2cnc(Nc3ccc(O)cc3)nc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4869608 OBDepict H 2 C NH O N O O N CH 3 CH 3 N HN O CH 3 N N CH 3 IC50 = 117.0 nM 543.63 C=CC(=O)Nc1cccc(N2C(=O)OC(C)(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4538751 OBDepict O N F F F N CH 3 H N N H N N H N N CH 3 IC50 = 170.0 nM 524.55 Cc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4594167 OBDepict CH 3 N H N N N N H N H N N N O F F F IC50 = 177.0 nM 525.54 CNc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4566796 OBDepict H 3 C O N N N N H N H N N CH 3 H N O F F F IC50 = 192.0 nM 554.58 COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4537673 OBDepict O N F F F N H 3 C H N N H N N H N N N H 3 C H 3 C IC50 = 276.0 nM 553.59 C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(N(C)C)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4852557 OBDepict CH 3 N N N H N N N O O H 3 C CH 3 IC50 = 300.5 nM 450.59 CC(C)C1OC(=O)N(C2CCCC2)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4436188 OBDepict O N F F F N H 3 C H N HN N N H N N IC50 = 325.0 nM 566.63 C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4850184 OBDepict CH 3 N H O N O O N N HN CH 3 CH 3 F F OH IC50 = 395.0 nM 469.45 CNC(=O)c1cccc(N2C(=O)OC(C(C)C)c3cnc(Nc4cc(F)c(O)c(F)c4)nc32)c1 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4874868 OBDepict H 3 C CH 3 O O N N N N H N NH IC50 = 410.0 nM 436.56 CC(C)C1OC(=O)N(C2CCCC2)c2nc(Nc3ccc(N4CCNCC4)cc3)ncc21 Homo sapiens CHEMBL4841342 single protein format
CHEMBL4552254 OBDepict O N F F F N N N H N N H N N H 3 C IC50 = 434.0 nM 510.52 Cc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380525 cell-based format
CHEMBL4744428 OBDepict O N H H O N N N N N N CH 3 H 3 C IC50 <= 500.0 nM 433.52 CC(C)n1cnnc1-c1cccc(NC(=O)[C@H]2CN(c3ccc(C4CC4)nc3)CCO2)n1 Homo sapiens CHEMBL4727565 assay format
CHEMBL4453292 OBDepict O N F F F N N N H N N H N N N CH 3 CH 3 IC50 = 528.0 nM 539.57 CN(C)c1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 Homo sapiens CHEMBL4380525 cell-based format