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Q9UL62 | TRPC5_HUMAN | Short transient receptor potential channel 5 (TRPC5)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4546097 OBDepict OH N O O N N CH 3 N O Cl Cl IC50 = 0.52 nM 475.33 Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1cccc(Cl)c1)n2Cc1ccc(Cl)cc1 Homo sapiens CHEMBL4377071 cell-based format
CHEMBL4581773 OBDepict H 3 C O N O N CH 3 O F OH IC50 <= 1.0 nM 400.45 CCCOc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4459054 OBDepict CH 3 O N O N CH 3 O F OH IC50 < 1.0 nM 414.48 CCCCOc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4426333 cell-based format
CHEMBL4476390 OBDepict OH N O O N CH 3 O O F F F IC50 <= 1.0 nM 514.5 Cn1c(=O)n(CCCCO)c(=O)c2c(Cc3ccccc3)c(Oc3cccc(OC(F)(F)F)c3)ccc21 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4554717 OBDepict OH N O O N CH 3 O F O F F F IC50 <= 1.0 nM 518.46 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(F)cc3)c(Oc3cccc(OC(F)(F)F)c3)ccc21 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4462719 OBDepict OH N O O N CH 3 O Cl IC50 <= 1.0 nM 450.92 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccccc3)c(Oc3cccc(Cl)c3)ccc21 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4466522 OBDepict OH N O O N N CH 3 N O Cl O F F F IC50 = 1.3 nM 524.88 Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1 Homo sapiens CHEMBL4377063 cell-based format
CHEMBL3920228 OBDepict OH N O O N H 3 C S O Cl F F F IC50 = 1.91 nM 524.95 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3cccc(OC(F)(F)F)c3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4466158 OBDepict OH N O O N H 3 C O H 3 C CH 3 F IC50 = 2.64 nM 400.45 CC(C)Oc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4426333 cell-based format
CHEMBL4525688 OBDepict OH N O O N CH 3 O O F F F IC50 = 2.69 nM 500.47 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccccc3)c(Oc3cccc(OC(F)(F)F)c3)ccc21 Homo sapiens CHEMBL4426333 cell-based format
CHEMBL4562137 OBDepict OH N O O N H 3 C O CH 3 F IC50 = 8.37 nM 372.4 COc1ccc2c(c1Cc1ccc(F)cc1)c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4426334 cell-based format
CHEMBL3932679 OBDepict HO N O O N O OH Cl Cl IC50 <= 21.0 nM 503.38 O=c1c2c(Cc3ccc(Cl)cc3)c(-c3cccc(Cl)c3)oc2n(CCCO)c(=O)n1CCCO Homo sapiens CHEMBL4377078 cell-based format
CHEMBL3949592 OBDepict OH N O O N CH 3 H 3 C S N Cl IC50 <= 21.0 nM 365.84 Cc1c(-c2cncc(Cl)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL3975501 OBDepict OH N O O N CH 3 H 3 C S O F F F IC50 < 21.0 nM 414.41 Cc1c(-c2ccccc2OC(F)(F)F)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4464289 OBDepict OH N O O N H 3 C O CH 3 IC50 = 27.0 nM 354.41 COc1ccc2c(c1Cc1ccccc1)c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4426333 cell-based format
CHEMBL3942703 OBDepict OH N O O N H 3 C S Cl Cl IC50 = 27.0 nM 475.4 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3cccc(Cl)c3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3942647 OBDepict OH N O O N CH 3 H 3 C S F IC50 = 27.0 nM 348.4 Cc1c(-c2cccc(F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3928277 OBDepict OH N O O N CH 3 CH 3 S Cl IC50 = 27.0 nM 364.85 Cc1c(-c2ccccc2Cl)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3937276 OBDepict OH N O O N CH 3 H 3 C S F F F F IC50 < 27.0 nM 416.4 Cc1c(-c2ccc(F)c(C(F)(F)F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3935541 OBDepict OH N O O N CH 3 CH 3 S Cl Cl IC50 < 27.0 nM 399.3 Cc1c(-c2ccc(Cl)c(Cl)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4451083 OBDepict OH N O O N H 3 C O F F F IC50 = 31.2 nM 484.47 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccccc3)c(-c3cccc(OC(F)(F)F)c3)ccc21 Homo sapiens CHEMBL4426333 cell-based format
CHEMBL3921389 OBDepict OH N O O N CH 3 CH 3 S Cl Cl IC50 = 31.6 nM 399.3 Cc1c(-c2cccc(Cl)c2Cl)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3964888 OBDepict OH N O O N H 3 C CH 3 S IC50 = 34.9 nM 380.47 Cc1c(-c2ccc3ccccc3c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4764636 OBDepict CH 3 N N N F F F N N N Cl N O H IC50 <= 50.0 nM 437.81 CN(c1cnccc1C(F)(F)F)c1ncnc2c1CCN(c1cn[nH]c(=O)c1Cl)C2 Homo sapiens CHEMBL4714709 cell-based format
CHEMBL4752870 OBDepict F O F F F N N N N Cl N O H IC50 <= 50.0 nM 441.77 O=c1[nH]ncc(N2CCc3c(ncnc3Oc3ccc(F)cc3C(F)(F)F)C2)c1Cl Homo sapiens CHEMBL4714709 cell-based format
CHEMBL4756125 OBDepict F Cl O N N N N Cl N O H IC50 <= 50.0 nM 408.22 O=c1[nH]ncc(N2CCc3c(ncnc3Oc3ccc(F)cc3Cl)C2)c1Cl Homo sapiens CHEMBL4714709 cell-based format
CHEMBL4743883 OBDepict O N H N Cl N N N O F F F IC50 <= 50.0 nM 423.78 O=c1[nH]ncc(N2CCc3c(ncnc3Oc3ccccc3C(F)(F)F)C2)c1Cl Homo sapiens CHEMBL4714709 cell-based format
CHEMBL4786096 OBDepict H 3 C O F N N N N Cl N O H IC50 <= 50.0 nM 401.83 CCc1c(F)cccc1Oc1ncnc2c1CCN(c1cn[nH]c(=O)c1Cl)C2 Homo sapiens CHEMBL4714709 cell-based format
CHEMBL4741465 OBDepict OH N N F F F N F N N Cl N O H IC50 <= 50.0 nM 484.84 O=c1[nH]ncc(N2CCc3c(ncnc3N(CCO)c3ccc(F)cc3C(F)(F)F)C2)c1Cl Homo sapiens CHEMBL4714709 cell-based format
CHEMBL3968651 OBDepict OH N O O N H 3 C S HO Cl Cl IC50 = 55.0 nM 491.4 Cn1c(=O)n(CCCO)c(=O)c2c(C(O)c3ccc(Cl)cc3)c(-c3cccc(Cl)c3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3973104 OBDepict OH N O O N CH 3 H 3 C S O F F F IC50 = 82.2 nM 414.41 Cc1c(-c2cccc(OC(F)(F)F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3958022 OBDepict OH N O O N CH 3 CH 3 S F F IC50 = 112.0 nM 366.39 Cc1c(-c2ccc(F)c(F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3946580 OBDepict OH N O O N H 3 C S O Cl Cl IC50 = 117.0 nM 491.4 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(Oc3cccc(Cl)c3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3905424 OBDepict OH N O O N H 3 C O Cl Cl IC50 = 134.0 nM 459.33 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3cccc(Cl)c3)oc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3948028 OBDepict OH N O O N CH 3 H 3 C S Cl IC50 = 168.0 nM 364.85 Cc1c(-c2ccc(Cl)cc2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3933741 OBDepict HO N O O N CH 3 S O OH O Cl F F F IC50 = 194.0 nM 556.95 Cn1c(=O)n(CCCO)c(=O)c2c(C(O)c3ccc(Cl)cc3)c(Oc3cccc(OC(F)(F)F)c3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4565087 OBDepict OH N O O N CH 3 N CH 3 H 3 C Cl IC50 = 195.0 nM 415.92 CC(C)CCc1c(-c2cccc(Cl)c2)ncc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4468755 OBDepict OH N O O N H 3 C N O F F F IC50 = 195.0 nM 485.46 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccccc3)c(-c3cccc(OC(F)(F)F)c3)ncc21 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4540858 OBDepict OH N O O N CH 3 N O Cl Cl IC50 = 195.0 nM 486.36 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(Oc3cccc(Cl)c3)ncc21 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4468311 OBDepict OH N O O N CH 3 N CH 3 H 3 C IC50 = 195.0 nM 353.42 CC(C)c1ccccc1-c1cc2c(=O)n(CCCO)c(=O)n(C)c2cn1 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4566586 OBDepict OH O O N O O N CH 3 N Cl Cl IC50 = 195.0 nM 514.37 Cn1c(=O)n(CCCOC(=O)O)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)ncc21 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4450304 OBDepict OH N O O N CH 3 N CH 3 H 3 C Cl IC50 = 195.0 nM 415.92 CC(C)CCc1c(-c2ccc(Cl)cc2)ncc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4439752 OBDepict OH N O O N H 3 C N CH 3 H 3 C Cl IC50 = 195.0 nM 477.99 CC(C)c1ccccc1-c1ncc2c(c1Cc1ccc(Cl)cc1)c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4467574 OBDepict OH N O O N CH 3 N H 3 C CH 3 H 3 C CH 3 IC50 = 195.0 nM 423.56 CC(C)CCc1c(-c2ccccc2C(C)C)ncc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL3903109 OBDepict OH N O O N CH 3 H 3 C S Cl IC50 = 226.0 nM 364.85 Cc1c(-c2cccc(Cl)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3945449 OBDepict OH N O O N H 3 C S Cl Cl IC50 = 242.0 nM 475.4 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4530872 OBDepict O N N N Cl N O F F F H IC50 = 280.0 nM 386.76 O=C1CN(c2cn[nH]c(=O)c2Cl)CCN1Cc1ccccc1C(F)(F)F Homo sapiens CHEMBL4410991 cell-based format
CHEMBL4442055 OBDepict OH OH O O HO Br IC50 = 280.0 nM 349.14 O=c1c(O)c(-c2ccccc2Br)oc2cc(O)cc(O)c12 Homo sapiens CHEMBL4377093 cell-based format
CHEMBL262766 OBDepict O N H S N H 3 C N N N F F F F F F IC50 = 300.0 nM 421.33 Cc1nnsc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C(F)(F)F)cc1 Homo sapiens CHEMBL4377097 single protein format
CHEMBL3952019 OBDepict OH N O O N CH 3 S CH 3 H 3 C O F F F IC50 = 340.0 nM 470.51 CC(C)CCc1c(-c2cccc(OC(F)(F)F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL3905720 OBDepict OH N O O N CH 3 S OH CH 3 H 3 C O F F F IC50 = 369.0 nM 486.51 CC(C)CC(O)c1c(-c2cccc(OC(F)(F)F)c2)sc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4452948 OBDepict O N N N Cl CH 3 CH 3 N O H IC50 = 380.0 nM 346.82 Cc1cccc(C)c1CN1CCN(c2cn[nH]c(=O)c2Cl)CC1=O Homo sapiens CHEMBL4410978 cell-based format
CHEMBL4435323 OBDepict OH N O O N N CH 3 H CH 3 O F F F IC50 = 408.0 nM 397.35 Cc1c(-c2cccc(OC(F)(F)F)c2)[nH]c2c(=O)n(CCCO)c(=O)n(C)c12 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4551101 OBDepict OH N O O N N CH 3 Cl Cl IC50 = 408.0 nM 458.35 Cn1c(=O)n(CCCO)c(=O)c2c1c(-c1cccc(Cl)c1)cn2Cc1ccc(Cl)cc1 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4473077 OBDepict OH N O O N N H 3 C O Cl F F F IC50 = 408.0 nM 507.9 Cn1c(=O)n(CCCO)c(=O)c2c1cc(-c1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4539201 OBDepict OH N O N O H 3 C N H 3 C Cl IC50 = 408.0 nM 361.83 Cc1cn(Cc2ccc(Cl)cc2)c2c(=O)n(CCCO)c(=O)n(C)c12 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4551497 OBDepict OH N O N O CH 3 N CH 3 CH 3 O F F F IC50 = 408.0 nM 411.38 Cc1c(-c2cccc(OC(F)(F)F)c2)n(C)c2c(=O)n(CCCO)c(=O)n(C)c12 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4576775 OBDepict OH N O N O CH 3 N CH 3 O F F F IC50 = 408.0 nM 397.35 Cn1c(-c2cccc(OC(F)(F)F)c2)cc2c1c(=O)n(CCCO)c(=O)n2C Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4444821 OBDepict OH N O O N N H 3 C Cl Cl IC50 = 408.0 nM 458.35 Cn1c(=O)n(CCCO)c(=O)c2c1cc(-c1cccc(Cl)c1)n2Cc1ccc(Cl)cc1 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL4565109 OBDepict OH N O O N N H 3 C H 3 C O Cl F F F IC50 = 408.0 nM 521.92 Cc1c(-c2cccc(OC(F)(F)F)c2)n(Cc2ccc(Cl)cc2)c2c(=O)n(CCCO)c(=O)n(C)c12 Homo sapiens CHEMBL4377078 cell-based format
CHEMBL309490 OBDepict OH OH O O HO IC50 = 450.0 nM 270.24 O=c1c(O)c(-c2ccccc2)oc2cc(O)cc(O)c12 Homo sapiens CHEMBL4377092 cell-based format
CHEMBL4536108 OBDepict O N N H 3 C H N Cl CH 3 N O H IC50 = 490.0 nM 346.82 Cc1ccccc1[C@H](C)N1CCN(c2cn[nH]c(=O)c2Cl)CC1=O Homo sapiens CHEMBL4410978 cell-based format
CHEMBL4440201 OBDepict O N N N Br CH 3 N O H IC50 = 500.0 nM 377.24 Cc1ccccc1CN1CCN(c2cn[nH]c(=O)c2Br)CC1=O Homo sapiens CHEMBL4410978 cell-based format
CHEMBL4475970 OBDepict O N N N Cl O N O H F F F IC50 = 530.0 nM 402.76 O=C1CN(c2cn[nH]c(=O)c2Cl)CCN1Cc1ccccc1OC(F)(F)F Homo sapiens CHEMBL4410978 cell-based format
CHEMBL4517031 OBDepict O N N H N Cl N O H H CH 3 IC50 = 530.0 nM 338.84 C[C@H]1CC[C@H](CN2CCN(c3cn[nH]c(=O)c3Cl)CC2=O)CC1 Homo sapiens CHEMBL4410978 cell-based format
CHEMBL3966562 OBDepict HO N O O N CH 3 S O Cl O F F F IC50 = 584.0 nM 540.95 Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(Oc3cccc(OC(F)(F)F)c3)sc21 Homo sapiens CHEMBL3889027 cell-based format
CHEMBL4563968 OBDepict O N N N Cl Cl N O H IC50 = 650.0 nM 353.21 O=C1CN(c2cn[nH]c(=O)c2Cl)CCN1Cc1ccccc1Cl Homo sapiens CHEMBL4410978 cell-based format
CHEMBL4449727 OBDepict F F F F N O N N Cl N O H IC50 = 650.0 nM 404.75 O=C1CN(c2cn[nH]c(=O)c2Cl)CCN1Cc1ccc(F)cc1C(F)(F)F Homo sapiens CHEMBL4410978 cell-based format
CHEMBL4551777 OBDepict O N N N Cl CH 3 N O H IC50 = 660.0 nM 332.79 Cc1ccccc1CN1CCN(c2cn[nH]c(=O)c2Cl)CC1=O Homo sapiens CHEMBL4410978 cell-based format