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Q9ULD8 | KCNH3_HUMAN | Potassium voltage-gated channel subfamily H member 3 (KCNH3)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3987187 OBDepict F NH N N N H N N H O ClH IC50 = 47.0 nM 412.86 Cl.Fc1ccc(Nc2nc(NCc3ccco3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3902034 OBDepict HN N N N H N N H O IC50 = 52.0 nM 358.41 c1ccc(Nc2nc(NCc3ccco3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3960526 OBDepict F N H N N HN N N H N N F IC50 = 58.0 nM 406.4 Fc1ccc(Nc2nc(NCc3ccncn3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3880086 cell-based format
CHEMBL3908982 OBDepict F N H N N HN N N H N N F IC50 = 65.0 nM 406.4 Fc1ccc(Nc2nc(NCc3ncccn3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3880086 cell-based format
CHEMBL3918973 OBDepict F NH N N N H N N H O F ClH IC50 = 73.0 nM 430.85 Cl.Fc1ccc(Nc2nc(NCc3ccco3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3979641 OBDepict F N H N N NH N N H N N IC50 = 77.0 nM 388.41 Fc1ccc(Nc2nc(NCc3ncccn3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3880086 cell-based format
CHEMBL3913727 OBDepict F N N H N N N N H NH ClH IC50 = 79.0 nM 423.88 Cl.Fc1cnccc1CNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3916475 OBDepict N H N N NH N N H N IC50 = 84.0 nM 369.43 c1ccc(Nc2nc(NCc3ccncc3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3912592 OBDepict NH 2 N N N H N N F N F ClH IC50 = 85.0 nM 441.87 Cl.Nc1nc(Nc2ccc(F)cc2)nc(N(Cc2ccnc(F)c2)c2ccccc2)n1 Homo sapiens CHEMBL3880086 cell-based format
CHEMBL3934480 OBDepict F N H N N NH N N H N F ClH IC50 = 85.0 nM 441.87 Cl.Fc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3918716 OBDepict CH 3 O N H N N NH N N H N N F IC50 = 92.0 nM 418.44 COc1ccc(Nc2nc(NCc3ncccn3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3880086 cell-based format
CHEMBL3941694 OBDepict F N H N N NH N N H N F F ClH IC50 = 100.0 nM 459.86 Cl.Fc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3930654 OBDepict F N H N N NH N N H N F ClH ClH IC50 = 110.0 nM 478.33 Cl.Cl.Fc1ccc(Nc2nc(NCc3ccncc3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3908600 OBDepict OH NH N N N H N NH F ClH IC50 = 110.0 nM 404.88 Cl.OCCCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3967925 OBDepict CH 3 NH H 3 C N N N H N HN F F F ClH IC50 = 140.0 nM 424.86 CC(C)Nc1nc(Nc2ccccc2)nc(Nc2ccc(C(F)(F)F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3905763 OBDepict OH N H N N N H N NH F ClH IC50 = 140.0 nM 418.9 Cl.OCCCCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3896688 OBDepict CH 3 O N H N N HN N N H N F F ClH IC50 = 170.0 nM 471.9 COc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(F)cc3)n2)cc1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3951510 OBDepict CH 3 NH H 3 C N N HN N N H IC50 = 180.0 nM 320.4 CC(C)Nc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3965780 OBDepict OH O N H N N N NH N H F F ClH IC50 = 180.0 nM 438.87 Cl.OCCOCCNc1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3899865 OBDepict OH N H N N N NH N H IC50 = 190.0 nM 364.45 OCCCCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3927512 OBDepict OH O N H N N N H N NH F ClH IC50 = 210.0 nM 420.88 Cl.OCCOCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3941035 OBDepict CH 3 NH H 3 C N N N H N HN F ClH IC50 = 220.0 nM 374.85 CC(C)Nc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3911132 OBDepict OH O N H N N N NH N H ClH IC50 = 240.0 nM 402.89 Cl.OCCOCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3986145 OBDepict CH 3 NH H 3 C N N HN N N H F F ClH IC50 = 240.0 nM 392.84 CC(C)Nc1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3933339 OBDepict CH 3 O N H N N NH N N H F F ClH IC50 = 240.0 nM 408.84 COCCNc1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3894011 OBDepict CH 3 N H N N NH N N H N F F ClH IC50 = 240.0 nM 455.9 Cc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(F)cc3)n2)cc1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3984483 OBDepict CH 3 O N H N N N H N NH F ClH IC50 = 250.0 nM 390.85 COCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3912562 OBDepict CH 3 O N H N N NH N N H N F F ClH IC50 = 250.0 nM 471.9 COc1cccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(F)cc3)n2)c1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3914321 OBDepict OH N H N N N NH N H F F ClH IC50 = 260.0 nM 436.89 Cl.OCCCCCNc1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3903792 OBDepict F N H N N NH N N H ClH IC50 = 290.0 nM 422.9 Cl.Fc1ccc(CNc2nc(Nc3ccccc3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3949366 OBDepict H 3 C O NH N N NH N N H CH 3 H 3 C ClH IC50 = 290.0 nM 386.89 COc1ccc(Nc2nc(Nc3ccccc3)nc(NC(C)C)n2)cc1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3960967 OBDepict NH N N N H N NH N IC50 = 290.0 nM 383.46 c1ccc(Nc2nc(NCCc3ccncc3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3906562 OBDepict CH 3 O HN N N N H N HN IC50 = 290.0 nM 336.4 COCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3963515 OBDepict HN N N N H N N H O IC50 = 320.0 nM 362.44 c1ccc(Nc2nc(NCC3CCCO3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3892216 OBDepict H 3 C NH H HO N N NH N HN F ClH IC50 = 340.0 nM 404.88 CC[C@@H](CO)Nc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3918211 OBDepict F N H N N NH N N H F F ClH IC50 = 350.0 nM 458.88 Cl.Fc1ccc(CNc2nc(Nc3ccc(F)cc3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3906656 OBDepict CH HN N N N H N HN ClH IC50 = 360.0 nM 352.83 C#CCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3972923 OBDepict F N H N N NH N N H F ClH IC50 = 390.0 nM 440.89 Cl.Fc1ccc(Nc2nc(NCc3ccccc3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3906537 OBDepict N H N N N NH N H ClH IC50 = 390.0 nM 404.91 Cl.c1ccc(CNc2nc(Nc3ccccc3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3981009 OBDepict CH 3 NH N N N NH N H IC50 = 390.0 nM 348.45 CCCCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3960018 OBDepict CH 3 NH H 3 C N N HN N N H + N + N O _ O O _ O ClH IC50 = 400.0 nM 446.86 CC(C)Nc1nc(Nc2ccc([N+](=O)[O-])cc2)nc(Nc2ccc([N+](=O)[O-])cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3959807 OBDepict CH 3 O N H N N N H N NH O H 3 C ClH IC50 = 420.0 nM 402.89 COCCNc1nc(Nc2ccccc2)nc(Nc2ccc(OC)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3891041 OBDepict HN N N N H N N H S ClH IC50 = 430.0 nM 410.93 Cl.c1ccc(Nc2nc(NCc3cccs3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3979725 OBDepict HO NH H 3 C H N N NH N HN F ClH IC50 = 450.0 nM 390.85 C[C@@H](CO)Nc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3928828 OBDepict F NH N N N H N N H O F ClH IC50 = 480.0 nM 434.88 Cl.Fc1ccc(Nc2nc(NCC3CCCO3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3913799 OBDepict O O N H N N N H N NH ClH IC50 = 480.0 nM 412.88 Cl.O=C1OCCC1CNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3986519 OBDepict CH 3 NH N N N H N HN CH 3 CH 3 ClH IC50 = 490.0 nM 370.89 Cc1cccc(Nc2nc(Nc3ccccc3)nc(NC(C)C)n2)c1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3943719 OBDepict CH 3 NH H 3 C N N N H N HN Cl ClH IC50 = 490.0 nM 391.31 CC(C)Nc1nc(Nc2ccccc2)nc(Nc2ccc(Cl)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3979376 OBDepict F NH N N N H N N H S F ClH IC50 = 490.0 nM 446.91 Cl.Fc1ccc(Nc2nc(NCc3cccs3)nc(Nc3ccc(F)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3968944 OBDepict O N H N N N HN N H ClH IC50 = 520.0 nM 412.93 Cl.c1ccc(Nc2nc(NCC3CCOCC3)nc(Nc3ccccc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3937315 OBDepict OH N H N N N H N NH F ClH IC50 = 550.0 nM 390.85 Cl.OCCCNc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3921020 OBDepict OH N H N N NH N N H ClH IC50 = 590.0 nM 372.86 Cl.OCCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2)n1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3895938 OBDepict CH 3 O N H N N NH N N H H 3 C CH 3 O H 3 C ClH IC50 = 630.0 nM 416.91 COc1cccc(Nc2nc(Nc3cccc(OC)c3)nc(NC(C)C)n2)c1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3922308 OBDepict F N H N N NH N N H N F Cl ClH IC50 = 650.0 nM 476.32 Cl.Fc1ccc(Nc2nc(NCc3ccnc(F)c3)nc(Nc3ccc(Cl)cc3)n2)cc1 Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3966002 OBDepict CH 3 O N H N N NH N N H H 3 C CH 3 O H 3 C ClH IC50 = 660.0 nM 416.91 COc1ccc(Nc2nc(Nc3ccc(OC)cc3)nc(NC(C)C)n2)cc1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3987203 OBDepict HO NH H 3 C H N N NH N HN F ClH IC50 = 700.0 nM 390.85 C[C@H](CO)Nc1nc(Nc2ccccc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3963496 OBDepict H 3 C HN CH 3 N N N H N NH CH 3 ClH IC50 = 720.0 nM 370.89 Cc1ccc(Nc2nc(Nc3ccccc3)nc(NC(C)C)n2)cc1.Cl Homo sapiens CHEMBL3879996 cell-based format
CHEMBL3974649 OBDepict CH 3 NH N N NH N N H F F ClH IC50 = 970.0 nM 420.89 CCCCCNc1nc(Nc2ccc(F)cc2)nc(Nc2ccc(F)cc2)n1.Cl Homo sapiens CHEMBL3879996 cell-based format