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Q9UPP1 | PHF8_HUMAN | Histone lysine demethylase PHF8 (PHF8)

3D structures mapped by conservation among orthologs

[ Domain: "FYVE/PHD zinc finger" // PHD ]

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[ Domain: "C-terminal helical domain in Jumonji domain-containing histone demethylases" // KOG1633 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4283711 OBDepict H N N N N N N F F F IC50 = 100.0 nM 384.37 FC(F)(F)c1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4281556 OBDepict H 3 C O F N CH 3 N N N N N H IC50 = 100.0 nM 350.36 COc1cc(-c2c(-c3cc(-c4c[nH]nn4)ccn3)ncn2C)ccc1F Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4282591 OBDepict H N N N N N N IC50 = 100.0 nM 366.43 c1ccc2c(CCn3cnc(-c4cc(-c5c[nH]nn5)ccn4)c3)cccc2c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4287550 OBDepict H N N N N N N Cl F F F IC50 = 100.0 nM 404.78 FC(F)(F)c1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1Cl Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4288588 OBDepict H N N N N N N Cl Cl IC50 = 100.0 nM 371.23 Clc1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1Cl Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4288982 OBDepict Cl Cl N N N N N F N H IC50 = 100.0 nM 389.22 Fc1[nH]nnc1-c1ccnc(-c2cn(Cc3cccc(Cl)c3Cl)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4292673 OBDepict Cl Cl N N N N N I N H IC50 = 100.0 nM 497.13 Clc1cccc(Cn2cnc(-c3cc(-c4nn[nH]c4I)ccn3)c2)c1Cl Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4282637 OBDepict H N N N N N N F Cl IC50 <= 100.0 nM 354.78 Fc1c(Cl)cccc1Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4279714 OBDepict CH 3 O N N N N N N H IC50 = 100.0 nM 346.39 COc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4283877 OBDepict H N N N N N N CH 3 IC50 = 100.0 nM 316.37 CC(c1ccccc1)n1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4281254 OBDepict H 3 C N N N N N N H IC50 = 100.0 nM 226.24 Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4284883 OBDepict H N N N N N N Cl IC50 <= 100.0 nM 350.81 Clc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4280770 OBDepict H N N N N N N IC50 = 100.0 nM 356.43 c1ccc2c(c1)CCCC2Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4294188 OBDepict CH 3 O N N N N N N H IC50 = 100.0 nM 360.42 CCOc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4279343 OBDepict H N N N N N N O F F F IC50 = 100.0 nM 414.39 FC(F)(F)COc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4281520 OBDepict F N H 3 C N N N N N H IC50 = 100.0 nM 320.33 Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1-c1ccc(F)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4294926 OBDepict H N N N N N N Cl IC50 = 100.0 nM 336.79 Clc1ccccc1Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4279599 OBDepict N N H N N N N N IC50 = 100.0 nM 381.44 N#Cc1[nH]nnc1-c1ccnc(-c2cn(CC3CCCc4ccccc43)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4278569 OBDepict N N H N N N N N IC50 = 100.0 nM 391.44 N#Cc1[nH]nnc1-c1ccnc(-c2cn(CCc3cccc4ccccc34)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4292796 OBDepict H N N N N N N O IC50 = 100.0 nM 386.46 c1ccc(OCC2CC2)c(CCn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4290290 OBDepict H N N N N N Br N Cl IC50 = 100.0 nM 415.68 Clc1ccccc1Cn1cnc(-c2cc(-c3cn[nH]n3)ccn2)c1Br Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4286675 OBDepict H N N N N N N IC50 = 100.0 nM 276.3 c1ccc(Cn2cnc(-c3cc4[nH]nnc4cn3)c2)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4286546 OBDepict H N N N F N N N IC50 = 100.0 nM 384.42 Fc1[nH]nnc1-c1ccnc(-c2cn(CCc3cccc4ccccc34)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4292067 OBDepict H N N N N N N O F F F IC50 = 100.0 nM 400.36 FC(F)(F)Oc1ccccc1CCn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4287368 OBDepict H N N N N N N CH 3 H 3 C Cl IC50 = 100.0 nM 378.87 CC(C)(Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1)c1ccccc1Cl Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4293827 OBDepict H N N N N N N O IC50 <= 100.0 nM 358.41 c1ccc2c(c1)OCCC2Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4283694 OBDepict CH 3 O F N N N N N N H IC50 = 100.0 nM 350.36 COc1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1F Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4293177 OBDepict H N N N N N N F CH 3 IC50 = 100.0 nM 334.36 Cc1cccc(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)c1F Homo sapiens CHEMBL4257000 cell-based format
CHEMBL3780833 OBDepict O N H CH 3 H N H N O OH IC50 < 250.0 nM 367.45 C[C@H](c1ccccc1)N1CCC[C@@H](CNCc2cc(C(=O)O)ccn2)C1=O Homo sapiens CHEMBL3782533 single protein format
CHEMBL3780958 OBDepict CH 3 O N CH 3 H O H N H N O OH IC50 < 250.0 nM 397.48 COc1ccc([C@@H](C)N2CCC[C@@H](CNCc3cc(C(=O)O)ccn3)C2=O)cc1 Homo sapiens CHEMBL3782533 single protein format
CHEMBL3781414 OBDepict CH 3 N O HN N O OH IC50 < 250.0 nM 277.32 CCN1CCC(CNCc2cc(C(=O)O)ccn2)C1=O Homo sapiens CHEMBL3782533 single protein format
CHEMBL3780689 OBDepict O N H CH 3 H N H N O OH IC50 < 250.0 nM 367.45 C[C@H](c1ccccc1)N1CCC[C@H](CNCc2cc(C(=O)O)ccn2)C1=O Homo sapiens CHEMBL3782533 single protein format
CHEMBL3779953 OBDepict CH 3 N N N N O OH IC50 < 250.0 nM 286.33 Cc1cn2c(n1)CCN(Cc1cc(C(=O)O)ccn1)CC2 Homo sapiens CHEMBL3782533 single protein format
CHEMBL3780904 OBDepict O N H H 3 C H N H N O HO IC50 < 250.0 nM 353.42 C[C@H](c1ccccc1)N1CC[C@@H](CNCc2cc(C(=O)O)ccn2)C1=O Homo sapiens CHEMBL3782533 single protein format
CHEMBL2164246 OBDepict NH 2 NH O O OH IC50 = 480.0 nM 132.12 NNC(=O)CCC(=O)O Homo sapiens CHEMBL2167523 assay format
CHEMBL2164243 OBDepict CH 3 N N H CH 3 O O HO IC50 = 550.0 nM 160.17 CN(C)NC(=O)CCC(=O)O Homo sapiens CHEMBL2167523 assay format
CHEMBL4289929 OBDepict F O N H 3 C N N N N H N IC50 = 1000.0 nM 364.38 Cn1cnc(-c2cc3[nH]nnc3cn2)c1-c1ccc(F)cc1OCC1CC1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4286185 OBDepict F N CH 3 N N N N H N IC50 = 1000.0 nM 294.29 Cn1cnc(-c2cc3[nH]nnc3cn2)c1-c1ccc(F)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4294250 OBDepict Cl Cl N N N N N H N IC50 = 1000.0 nM 331.17 Clc1cc(Cl)cc(-n2cnc(-c3cc4[nH]nnc4cn3)c2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4283409 OBDepict Cl N N N N N H N IC50 = 1000.0 nM 296.72 Clc1cccc(-n2cnc(-c3cc4[nH]nnc4cn3)c2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4279782 OBDepict Cl N N N N N H N IC50 = 1000.0 nM 296.72 Clc1ccccc1-n1cnc(-c2cc3[nH]nnc3cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4278748 OBDepict Cl N N N N N H N IC50 = 1000.0 nM 296.72 Clc1ccc(-n2cnc(-c3cc4[nH]nnc4cn3)c2)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4280949 OBDepict Cl Cl N N N N N H N IC50 = 1000.0 nM 345.19 Clc1ccc(Cn2cnc(-c3cc4[nH]nnc4cn3)c2)cc1Cl Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4293021 OBDepict H N N N N N N O IC50 = 1000.0 nM 408.47 c1ccc(Oc2ccccc2CCn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4292860 OBDepict Cl N N N N N H N IC50 = 1000.0 nM 310.75 Clc1cccc(Cn2cnc(-c3cc4[nH]nnc4cn3)c2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4281332 OBDepict Cl N N N N N H N IC50 = 1000.0 nM 310.75 Clc1ccccc1Cn1cnc(-c2cc3[nH]nnc3cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4294067 OBDepict H N N N N N N O IC50 = 1000.0 nM 422.49 c1ccc(COc2ccccc2CCn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4282958 OBDepict H N N N N N N IC50 = 1000.0 nM 240.27 c1nc(-c2cn(CC3CC3)cn2)cc2[nH]nnc12 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4277370 OBDepict F O N CH 3 N N N N F N H IC50 = 1000.0 nM 408.41 Cn1cnc(-c2cc(-c3nn[nH]c3F)ccn2)c1-c1ccc(F)cc1OCC1CC1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4277342 OBDepict N N H N N N N N CH 3 O F IC50 = 1000.0 nM 415.43 Cn1cnc(-c2cc(-c3nn[nH]c3C#N)ccn2)c1-c1ccc(F)cc1OCC1CC1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4289641 OBDepict H N N N Cl N N N IC50 = 1000.0 nM 400.87 Clc1[nH]nnc1-c1ccnc(-c2cn(CCc3cccc4ccccc34)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4280474 OBDepict F O N CH 3 N N N N N H IC50 = 1000.0 nM 390.42 Cn1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1-c1ccc(F)cc1OCC1CC1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4291030 OBDepict H N N N N N N H 3 C IC50 = 1000.0 nM 330.4 CC(Cc1ccccc1)n1cnc(-c2cc(-c3c[nH]nn3)ccn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4292175 OBDepict H N N N N N N IC50 = 1000.0 nM 392.47 c1ccc(-c2ccccc2CCn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4289127 OBDepict H N N N N N N F O F F F IC50 = 1000.0 nM 404.33 Fc1c(Cn2cnc(-c3cc(-c4c[nH]nn4)ccn3)c2)cccc1OC(F)(F)F Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4288093 OBDepict CH 3 O F N CH 3 N N N N N H IC50 = 1000.0 nM 364.38 CCOc1cc(-c2c(-c3cc(-c4c[nH]nn4)ccn3)ncn2C)ccc1F Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4288710 OBDepict N N H N N N N N Cl IC50 = 1000.0 nM 375.82 N#Cc1[nH]nnc1-c1ccnc(-c2cn(CCc3ccccc3Cl)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4291673 OBDepict N N H N N N N N Cl Cl IC50 = 1000.0 nM 410.27 N#Cc1[nH]nnc1-c1ccnc(-c2cn(CCc3cccc(Cl)c3Cl)cn2)c1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4279899 OBDepict Cl N N N N N H N IC50 = 1000.0 nM 310.75 Clc1ccc(Cn2cnc(-c3cc4[nH]nnc4cn3)c2)cc1 Homo sapiens CHEMBL4257000 cell-based format
CHEMBL4287712 OBDepict H N N N N N N F F F IC50 = 1000.0 nM 268.2 FC(F)(F)Cn1cnc(-c2cc3[nH]nnc3cn2)c1 Homo sapiens CHEMBL4257000 cell-based format