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Q9UQB9 | AURKC_HUMAN | Aurora kinase C (AURKC)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2140408 OBDepict CH 3 S N N N H O N N N NH 2 IC50 = 1.0 nM 503.59 Cc1csc(-c2nnc(Nc3ccc(Oc4ncccc4-c4ccnc(N)n4)cc3)c3ccccc23)c1 Homo sapiens CHEMBL4266268 single protein format
CHEMBL1090479 OBDepict H 3 C N N N N HN H N O H 3 C CH 3 N CH 3 CH 3 Ki = 1.5 nM 507.64 CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 Homo sapiens CHEMBL1104797 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 2.42 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328315 single protein format
CHEMBL4277690 OBDepict O N H N H NH S Cl N H N N S IC50 = 3.0 nM 432.96 O=C(Nc1cccc(Cl)c1)NC1NC=C(CCNc2ncnc3sccc23)S1 Homo sapiens CHEMBL4266268 single protein format
CHEMBL3393498 OBDepict H 3 C O O N H HN H O O N N H IC50 = 3.0 nM 468.51 CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)[C@H]2c1cccc(Oc2nc3ccccc3[nH]2)c1 Homo sapiens CHEMBL3396727 single protein format
CHEMBL572878 OBDepict CH 3 N N N S N HN N N CH 3 H N H O Ki = 4.6 nM 464.6 Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 Homo sapiens CHEMBL873733 single protein format
CHEMBL1090479 OBDepict H 3 C N N N N HN H N O H 3 C CH 3 N CH 3 CH 3 IC50 = 6.5 nM 507.64 CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 Homo sapiens CHEMBL1104797 single protein format
CHEMBL1980297 OBDepict OH N N N S H 2 N N H NH O F IC50 = 7.0 nM 488.55 Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 Homo sapiens CHEMBL4671028 single protein format
CHEMBL484950 OBDepict CH 3 N H O S N N HN N H N H 3 C Ki = 11.0 nM 390.47 CC(=O)Nc1ccc(Sc2nc(Nc3cc(C)n[nH]3)c3ccccc3n2)cc1 Homo sapiens CHEMBL1031296 single protein format
CHEMBL3600873 OBDepict OH O N H O N H F N S Cl IC50 = 12.0 nM 461.95 O=C(O)[C@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](Oc2cccc(Cl)c2F)CC1 Homo sapiens CHEMBL3871600 assay format
CHEMBL215152 OBDepict OH N CH 3 O N N N H N N H N H O F Ki = 17.0 nM 507.57 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 Homo sapiens CHEMBL856429 single protein format
CHEMBL605003 OBDepict O HN N H S N O O H 3 C CH 3 IC50 = 17.0 nM 371.46 CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCCC3)C(=O)N2 Homo sapiens CHEMBL1062878 single protein format
CHEMBL415049 OBDepict CH 3 N O P O O OH OH N N N H N N H HN O F IC50 = 17.0 nM 587.55 CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O Homo sapiens CHEMBL1104797 single protein format
CHEMBL1086579 OBDepict H 3 C N N N N H N N Br N N O CH 3 IC50 = 19.0 nM 475.4 Cc1cc(CN2CCN(c3c(Br)cnc4[nH]c(N5CCN(C)CC5)nc34)CC2)no1 Homo sapiens CHEMBL1118618 assay format
CHEMBL4206831 OBDepict CH 3 NH O NH O N H N N N N CH 3 CH 3 O H 3 C IC50 = 53.0 nM 535.61 CCC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1 Homo sapiens CHEMBL4185636 assay format
CHEMBL402548 OBDepict CH 3 O H N O N N N H H O N N CH 3 IC50 = 61.0 nM 474.57 CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 Homo sapiens CHEMBL911835 single protein format
CHEMBL402548 OBDepict CH 3 O H N O N N N H H O N N CH 3 Ki = 61.0 nM 474.57 CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 Homo sapiens CHEMBL931998 single protein format
CHEMBL1258913 OBDepict O N H N N S N H N H O O H N IC50 = 62.0 nM 544.68 O=C(Nc1n[nH]c2cc(C(=O)N[C@H](CN3CCCC3)c3ccccc3)sc12)c1ccc(N2CCOCC2)cc1 Homo sapiens CHEMBL1260158 single protein format
CHEMBL3969370 OBDepict CH 2 NH O NH O N H N N N N CH 3 CH 3 O H 3 C IC50 = 63.0 nM 533.59 C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1 Homo sapiens CHEMBL4185636 assay format
CHEMBL482967 OBDepict NH 2 N S H 3 C N N N H N O IC50 = 65.0 nM 368.47 Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 Homo sapiens CHEMBL993742 single protein format
CHEMBL3322563 OBDepict O N H N H O N H O F N H IC50 = 67.2 nM 404.4 O=C(CC(=O)Nc1ccc2c(c1)NC(=O)/C2=Cc1ccc[nH]1)Nc1ccc(F)cc1 Homo sapiens CHEMBL3362103 single protein format
CHEMBL572878 OBDepict CH 3 N N N S N HN N N CH 3 H N H O IC50 = 70.0 nM 464.6 Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 Homo sapiens CHEMBL1051321 single protein format
CHEMBL363160 OBDepict CH 3 N H N O H 3 C N HN N H O N N H 3 C IC50 = 120.0 nM 501.64 CCc1cccc(CC)c1NC(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1 Homo sapiens CHEMBL831067 single protein format
CHEMBL3322565 OBDepict CH 3 O N H O N H O N H O N H 3 C H CH 3 O OH IC50 = 153.5 nM 488.5 COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2[nH]c(C)c(C(=O)O)c2C)cc1 Homo sapiens CHEMBL3362103 single protein format
CHEMBL409450 OBDepict HO N N H O HN Br IC50 = 200.0 nM 356.18 O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=NO Homo sapiens CHEMBL894339 single protein format
CHEMBL274654 OBDepict OH O CH 3 N H 3 C H O N H IC50 = 210.0 nM 310.35 Cc1[nH]c(/C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O Homo sapiens CHEMBL1062878 single protein format
CHEMBL392525 OBDepict O NH N N S N Cl N N N H N CH 3 H 3 C IC50 = 227.0 nM 497.03 CN(C)c1ccc(-c2nc3c(N4CCN(CC(=O)Nc5nccs5)CC4)c(Cl)cnc3[nH]2)cc1 Homo sapiens CHEMBL899965 single protein format
CHEMBL3133821 OBDepict HO N H N N H IC50 = 259.0 nM 275.31 Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 Homo sapiens CHEMBL3134649 single protein format
CHEMBL2436978 OBDepict CH 3 N N N N H N H IC50 = 290.0 nM 421.55 CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 Homo sapiens CHEMBL2439769 single protein format
CHEMBL126077 OBDepict O N N H OH N H IC50 = 300.0 nM 277.28 O=Nc1c(-c2c(O)[nH]c3ccccc23)[nH]c2ccccc12 Homo sapiens CHEMBL894339 single protein format
CHEMBL188343 OBDepict H N N N N H N N H N O IC50 = 400.0 nM 393.5 c1nc2c(NC3CCCCC3)nc(Nc3ccc(N4CCOCC4)cc3)nc2[nH]1 Homo sapiens CHEMBL4610951 assay format
CHEMBL211243 OBDepict H 3 C O N N OH N H IC50 = 400.0 nM 291.31 CO/N=C1C(c2c(O)[nH]c3ccccc23)=Nc2ccccc21 Homo sapiens CHEMBL894339 single protein format
CHEMBL209648 OBDepict O N N H HO N H I IC50 = 600.0 nM 403.18 O=Nc1c(-c2c(O)[nH]c3c(I)cccc23)[nH]c2ccccc12 Homo sapiens CHEMBL894339 single protein format
CHEMBL373834 OBDepict O N N H HO N H Br IC50 = 700.0 nM 356.18 O=Nc1c(-c2c(O)[nH]c3c(Br)cccc23)[nH]c2ccccc12 Homo sapiens CHEMBL894339 single protein format
CHEMBL209849 OBDepict H 3 C O O N N HO N H IC50 = 700.0 nM 319.32 CC(=O)O/N=C1C(c2c(O)[nH]c3ccccc23)=Nc2ccccc21 Homo sapiens CHEMBL894339 single protein format
CHEMBL213650 OBDepict O N N H HO N H Cl IC50 = 900.0 nM 311.73 O=Nc1c(-c2c(O)[nH]c3c(Cl)cccc23)[nH]c2ccccc12 Homo sapiens CHEMBL894339 single protein format
CHEMBL212174 OBDepict O N N H HO N H F IC50 = 1000.0 nM 295.27 O=Nc1c(-c2c(O)[nH]c3c(F)cccc23)[nH]c2ccccc12 Homo sapiens CHEMBL894339 single protein format
CHEMBL243985 OBDepict H 3 C O O N N H O NH F IC50 = 1000.0 nM 337.31 CC(=O)O/N=C1C(=C2C(=O)Nc3c(F)cccc32)Nc2ccccc21 Homo sapiens CHEMBL894339 single protein format