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Q9UQD0 | SCN8A_HUMAN | Sodium channel protein type 8 subunit alpha (SCN8A)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3617063 OBDepict Cl O N F N F H H 2 N S HN O O N S N IC50 = 0.8 nM 534.96 Nc1nc2cc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)ccc2[nH]1 Homo sapiens CHEMBL3806747 cell-based format
CHEMBL501134 OBDepict HN N H HN H N H NH OH HO O NH O H 2 N IC50 = 1.1 nM 299.29 N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 Homo sapiens CHEMBL4321996 cell-based format
CHEMBL507974 OBDepict HO OH H O H O H OH H OH N H H OH N H OH H 2 N IC50 = 2.3 nM 319.27 NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO Homo sapiens CHEMBL4321996 cell-based format
CHEMBL3341983 OBDepict Cl O F O NH 2 N F S NH O O N S N IC50 = 11.0 nM 535.94 Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 Homo sapiens CHEMBL3806747 cell-based format
CHEMBL3662190 OBDepict O N H S F O O O H 3 C IC50 = 38.0 nM 435.56 CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 Homo sapiens CHEMBL4321996 cell-based format
CHEMBL4290579 OBDepict O S N H O N N N O IC50 = 92.0 nM 442.59 O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12)C1CC1 Homo sapiens CHEMBL4256592 cell-based format
CHEMBL2325014 OBDepict Cl O N NH 2 N H Cl F S NH O O N S IC50 = 160.0 nM 500.36 Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl Homo sapiens CHEMBL4321996 cell-based format
CHEMBL3707218 OBDepict O N O O O O F F F IC50 = 170.0 nM 429.35 O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@]12COc1cc3c(cc12)OCO3 Homo sapiens CHEMBL4321996 cell-based format
CHEMBL4279238 OBDepict H 3 C S HN O O N N N O IC50 = 190.0 nM 416.55 CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12 Homo sapiens CHEMBL4256592 cell-based format
CHEMBL4854735 OBDepict F N HN S O O F F O H H N F F F F F IC50 = 230.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 Homo sapiens CHEMBL4813116 single protein format
CHEMBL3657855 OBDepict F O N H O S N O O IC50 = 480.0 nM 462.59 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL4321996 cell-based format
CHEMBL698 OBDepict H 3 C NH O O N CH 3 H 3 C IC50 = 520.0 nM 264.37 CCCCNc1ccc(C(=O)OCCN(C)C)cc1 Homo sapiens CHEMBL3800779 cell-based format
CHEMBL3979498 OBDepict H 3 C O N O F F F S NH O O N N IC50 = 650.0 nM 552.53 COc1cc(-c2cccc(C(F)(F)F)c2)ccc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ncccn3)ccc21 Homo sapiens CHEMBL4012362 cell-based format
CHEMBL512079 OBDepict NH 2 N N O N N IC50 = 660.0 nM 305.34 NCc1noc(-c2nn(Cc3ccccc3)c3ccccc23)n1 Homo sapiens CHEMBL971451 cell-based format