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Q9Y210 | TRPC6_HUMAN | Short transient receptor potential channel 6 (TRPC6)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4764496 OBDepict H 3 C N N N N F H NH 2 F H F IC50 = 0.1 nM 375.4 Cc1ccc(Cn2c(N3CC[C@@H](F)[C@H](N)C3)nc3cc(F)c(F)cc32)nc1 Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4741505 OBDepict F N N N N N H H 2 N F H F IC50 = 0.2 nM 362.36 N[C@@H]1CN(c2nc3ccc(F)cc3n2Cc2ncc(F)cn2)CC[C@H]1F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4752852 OBDepict F N N N N H NH 2 F F Cl IC50 = 0.3 nM 395.82 N[C@@H]1CN(c2nc3cc(F)ccc3n2Cc2ccc(Cl)cn2)CCC1(F)F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4753871 OBDepict F N N N N N H NH 2 H F F IC50 = 0.4 nM 362.36 N[C@@H]1CN(c2nc3cc(F)ccc3n2Cc2ncc(F)cn2)CC[C@H]1F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4776935 OBDepict CH 3 O F N N N N N H NH 2 Cl H F IC50 = 0.4 nM 408.84 COc1cc(F)c2nc(N3CC[C@@H](F)[C@H](N)C3)n(Cc3ncc(Cl)cn3)c2c1 Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4746182 OBDepict F N N N N H H 2 N F H F IC50 = 0.4 nM 361.37 N[C@@H]1CN(c2nc3ccc(F)cc3n2Cc2ccc(F)cn2)CC[C@H]1F Homo sapiens CHEMBL4725099 cell-based format
CHEMBL4129456 OBDepict N O H H N CH 3 H H NH 2 F IC50 = 3.0 nM 369.48 C[C@]12CCC(F)=C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418809 OBDepict CH 3 CH 3 N O N Cl S N H F O O IC50 = 4.0 nM 411.89 CC1CCCN(C(=O)c2nc(Nc3cc4c(cc3F)OCO4)sc2Cl)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4129805 OBDepict N O H H N H H H O H H H 2 N IC50 = 8.0 nM 365.48 N#Cc1ccc(O[C@@H]2[C@H]3[C@@H]4C[C@@H](CC4=O)[C@H]3C[C@H]2N2CCC[C@@H](N)C2)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4129809 OBDepict N Cl O H H N H NH 2 IC50 = 9.5 nM 367.88 N#Cc1ccc(O[C@@H]2c3ccccc3C[C@H]2N2CCC[C@@H](N)C2)c(Cl)c1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4127600 OBDepict N O H H N CH 3 H H NH 2 O IC50 = 11.0 nM 367.49 C[C@]12CCC(=O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418811 OBDepict Cl F N H S N H 3 C N O H H 3 C H CH 3 IC50 = 16.0 nM 381.9 Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCC[C@H](C)[C@@H]1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL2418807 OBDepict CH 3 H 3 C N O N S N H O O IC50 = 16.0 nM 359.45 CC1CCCN(C(=O)c2csc(Nc3ccc4c(c3)OCO4)n2)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4126041 OBDepict N O H H N H H O H NH 2 IC50 = 22.0 nM 339.44 N#Cc1ccc(O[C@@H]2[C@@H]3CCC(=O)[C@@H]3C[C@H]2N2CCC[C@@H](N)C2)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418808 OBDepict H 3 C CH 3 N O N CH 3 S N H F O O IC50 = 25.0 nM 391.47 Cc1sc(Nc2cc3c(cc2F)OCO3)nc1C(=O)N1CCCC(C)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4128079 OBDepict N O H H N CH 3 H H NH 2 F F IC50 = 30.0 nM 389.49 C[C@]12CCC(F)(F)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418815 OBDepict O N N CH 3 CH 3 S N H O O IC50 = 32.0 nM 407.5 Cc1sc(Nc2ccc3c(c2)OCO3)nc1C(=O)N1CCc2ccccc2C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4128782 OBDepict H 3 C O N H H 3 C H O H N H H 2 N N IC50 = 33.0 nM 396.54 CO/N=C1CC[C@@]2(C)[C@@H](C1)C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4127190 OBDepict N O H H N CH 3 H H NH 2 IC50 = 37.0 nM 353.51 C[C@]12CCCC[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4125756 OBDepict N O H H N CH 3 H H NH 2 H HO IC50 = 49.0 nM 369.51 C[C@]12CC[C@@H](O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418810 OBDepict CH 3 CH 3 N O N CH 3 S N H F Cl IC50 = 50.0 nM 381.9 Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCCC(C)C1C Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4126989 OBDepict N O H H N CH 3 H H NH 2 H O H 3 C IC50 = 52.0 nM 383.54 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418814 OBDepict O N N CH 3 S N H O O IC50 = 63.0 nM 393.47 CC1c2ccccc2CCN1C(=O)c1csc(Nc2ccc3c(c2)OCO3)n1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL2418806 OBDepict CH 3 H 3 C N O N S N H H 3 C IC50 = 80.0 nM 329.47 Cc1ccc(Nc2nc(C(=O)N3CCCC(C)C3C)cs2)cc1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL2418813 OBDepict O N N S N H O O IC50 = 160.0 nM 379.44 O=C(c1csc(Nc2ccc3c(c2)OCO3)n1)N1CCc2ccccc2C1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4130214 OBDepict N O H H N H H O H NH 2 IC50 = 160.0 nM 325.41 N#Cc1ccc(O[C@@H]2[C@@H]3CC(=O)[C@@H]3C[C@H]2N2CCC[C@@H](N)C2)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418823 OBDepict CH 3 N O N S N H O O IC50 = 160.0 nM 345.42 CC1CCN(C(=O)c2csc(Nc3ccc4c(c3)OCO4)n2)CC1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4567792 OBDepict H 2 C HO H 3 C H H 2 C CH 3 H H O CH 3 H 3 C O H 2 N IC50 = 170.0 nM 349.52 C=C[C@](C)(O)CC[C@H]1C(=C)C[C@H](OC(N)=O)[C@H]2C(C)(C)CCC[C@]12C Homo sapiens CHEMBL4377104 cell-based format
CHEMBL4129002 OBDepict N O H H N CH 3 H H NH 2 H F F IC50 = 200.0 nM 403.52 C[C@]12CC[C@H](C(F)F)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4126938 OBDepict N O H H N H 3 C H H H 2 N CH 3 OH IC50 = 210.0 nM 383.54 CC1(O)CC[C@@]2(C)[C@H](C[C@@H](N3CCC[C@@H](N)C3)[C@@H]2Oc2ccc(C#N)cc2)C1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4458930 OBDepict CH 2 O CH 3 O H 3 C H H 2 C CH 3 H H O CH 3 H 3 C O H 2 N IC50 = 250.0 nM 391.55 C=C[C@@](C)(CC[C@H]1C(=C)C[C@H](OC(N)=O)[C@H]2C(C)(C)CCC[C@]12C)OC(C)=O Homo sapiens CHEMBL4377104 cell-based format
CHEMBL4126435 OBDepict N O H H N H 3 C H H H 2 N N O H 3 C CH 3 IC50 = 280.0 nM 436.6 CN(C)C(=O)/C=C1CC[C@@]2(C)[C@@H](C1)C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4126528 OBDepict N O H H N CH 3 H H NH 2 O IC50 = 390.0 nM 367.49 C[C@@]12CCC(=O)C[C@@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418818 OBDepict H 3 C N O N S N H CH 3 IC50 = 400.0 nM 315.44 Cc1ccc(Nc2nc(C(=O)N3CCC(C)CC3)cs2)cc1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4127992 OBDepict N O H H N CH 3 H H NH 2 H O H 3 C IC50 = 440.0 nM 383.54 CO[C@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL4129133 OBDepict N O H H N H H 2 N IC50 = 500.0 nM 285.39 N#Cc1ccc(O[C@@H]2CCC[C@H]2N2CCC[C@@H](N)C2)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL1506485 OBDepict H 3 C O N H S N N O IC50 = 500.0 nM 365.46 COc1ccc(Nc2nc(C(=O)N3CCc4ccccc4C3)cs2)cc1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4129913 OBDepict N O H H N CH 3 H H NH 2 H HO IC50 = 560.0 nM 369.51 C[C@]12CC[C@H](O)C[C@H]1C[C@@H](N1CCC[C@@H](N)C1)[C@@H]2Oc1ccc(C#N)cc1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418822 OBDepict H 3 C N O N S N H F Cl IC50 = 630.0 nM 353.85 CC1CCN(C(=O)c2csc(Nc3ccc(Cl)cc3F)n2)CC1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL2418824 OBDepict H 3 C N H S N N O H 3 C IC50 = 630.0 nM 315.44 Cc1ccc(Nc2nc(C(=O)N3CCCCC3C)cs2)cc1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL4125839 OBDepict N Cl O H H N H H 2 N IC50 = 660.0 nM 319.84 N#Cc1ccc(O[C@@H]2CCC[C@H]2N2CCC[C@@H](N)C2)c(Cl)c1 Homo sapiens CHEMBL4122824 cell-based format
CHEMBL2418820 OBDepict CH 3 O N H S N N O H 3 C IC50 = 800.0 nM 331.44 COc1ccc(Nc2nc(C(=O)N3CCC(C)CC3)cs2)cc1 Homo sapiens CHEMBL2422303 cell-based format
CHEMBL2418819 OBDepict CH 3 N O N S N H Cl IC50 = 800.0 nM 335.86 CC1CCN(C(=O)c2csc(Nc3ccc(Cl)cc3)n2)CC1 Homo sapiens CHEMBL2422303 cell-based format