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Q9Y243 | AKT3_HUMAN | RAC-gamma serine/threonine-protein kinase (AKT3)

3D structures mapped by conservation among orthologs

[ Domain: "PH domain-like" // PH ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -1300.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804340 cell-based format
CHEMBL4441825 OBDepict HO H N H H H N H O F O F Cl N Cl CH 3 N IC50 = 0.12 nM 499.35 Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl Homo sapiens CHEMBL4407365 single protein format
CHEMBL1099276 OBDepict NH 2 O H N N N CH 3 OH H 3 C H 3 C N O H 2 N N IC50 = 1.0 nM 447.5 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(O[C@@H](CN)c3ccccc3)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL482536 OBDepict H 2 N N H H O S Br F F F N N H IC50 = 1.0 nM 523.38 NC[C@H](Cc1cccc(C(F)(F)F)c1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL2177387 OBDepict CH 2 H N N N N O H HN CH 3 H 3 C Cl IC50 = 1.0 nM 454.02 C=C[C@@H]1CCc2ncnc(N3CCN(C(=O)[C@H](CNC(C)C)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL593374 OBDepict NH 2 N O H 3 C O H 2 N H N CH 3 N N H H IC50 = 1.0 nM 492.58 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2[nH]nc(C)c2c1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL594072 OBDepict NH 2 N O N CH 3 O NH 2 H N N H 3 C N N H O NH 2 H IC50 = 1.0 nM 537.58 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c(C(N)=O)[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL593490 OBDepict H N N H 3 C N O O NH 2 H N H IC50 = 1.0 nM 463.54 Cc1[nH]nc2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 Homo sapiens CHEMBL1069943 single protein format
CHEMBL605410 OBDepict N N H NH 2 H O NH 2 N N N CH 3 O N H 3 C N H IC50 = 1.0 nM 519.57 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c(C#N)[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL594933 OBDepict H N H 2 N H O N N O N CH 3 N H IC50 = 1.0 nM 464.53 Cc1n[nH]c2cnc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 Homo sapiens CHEMBL1069943 single protein format
CHEMBL3137336 OBDepict H 2 N N H H O O F Cl F N Cl H 3 C N IC50 = 1.3 nM 429.25 Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2ccc(F)c(F)c2)oc1Cl Homo sapiens CHEMBL4407365 single protein format
CHEMBL4440965 OBDepict H 3 C NH O H HN H H NH O F O F Cl N Cl CH 3 N IC50 = 1.7 nM 526.37 CNC(=O)C[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 Homo sapiens CHEMBL4407365 single protein format
CHEMBL524998 OBDepict H 2 N N H H O S Br O H 3 C N N H IC50 = 2.0 nM 485.41 COc1ccc(C[C@@H](CN)NC(=O)c2cc(Br)c(-c3ccnc4[nH]ccc34)s2)cc1 Homo sapiens CHEMBL959246 single protein format
CHEMBL593813 OBDepict NH 2 N O N H 3 C O H 2 N H N N CH 3 N Cl N H H IC50 = 2.0 nM 529.0 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c(Cl)[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL593375 OBDepict NH 2 N O H 3 C O H 2 N H N N CH 3 N N H H IC50 = 2.0 nM 493.57 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2c1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL2178598 OBDepict OH HN CH 3 CH 3 H N O F N F F F N N H H 3 C H OH IC50 = 2.0 nM 539.57 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC(C)(C)CO)c4ccc(C(F)(F)F)c(F)c4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL498052 OBDepict NH 2 N H H O F S Br N N H IC50 = 2.0 nM 473.37 NC[C@H](Cc1ccccc1F)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL2177361 OBDepict O N H N H N F N F F F N H CH 3 H HO IC50 = 2.0 nM 521.56 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC4CC4)c4ccc(C(F)(F)F)c(F)c4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL520788 OBDepict NH 2 N H H O S F F F Br N N H IC50 = 2.0 nM 523.38 NC[C@H](Cc1ccccc1C(F)(F)F)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL496690 OBDepict NH 2 N H H O S Br F N N H IC50 = 2.0 nM 473.37 NC[C@H](Cc1ccc(F)cc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL523586 OBDepict NH 2 N H H O S F Br N N H IC50 = 2.0 nM 473.37 NC[C@H](Cc1cccc(F)c1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL470597 OBDepict NH 2 N H H O S Br N N H IC50 = 2.0 nM 455.38 NC[C@H](Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL595944 OBDepict NH 2 N O N H 3 C O H 2 N H N N CH 3 N N H H IC50 = 2.0 nM 494.56 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL1098938 OBDepict H 3 C N N N O NH 2 N O N H 2 N H OH H 3 C H 3 C IC50 = 3.0 nM 461.53 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@H](N)Cc3ccccc3)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL469590 OBDepict NH 2 N H O S Br N N H IC50 = 3.0 nM 455.38 NCC(Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL470598 OBDepict NH 2 N H H O S Br N N H IC50 = 3.0 nM 461.43 NC[C@H](CC1CCCCC1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL213618 OBDepict H 3 C NH N N S N H O H NH 2 Cl Cl IC50 = 3.0 nM 436.37 CNc1nccc(-c2ccc(C(=O)N[C@H](CN)Cc3ccc(Cl)cc3Cl)s2)n1 Homo sapiens CHEMBL868609 single protein format
CHEMBL2178597 OBDepict O N H N H N F H 3 C CH 3 H 3 C N F F F N H H 3 C H OH IC50 = 3.0 nM 523.58 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC(C)(C)C)c4ccc(C(F)(F)F)c(F)c4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL595459 OBDepict H 2 N N O N H 3 C O H 2 N H N CH 3 N N H H IC50 = 3.0 nM 493.57 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cc2c(C)n[nH]c2cn1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL482537 OBDepict NH 2 N H H O S Br F F F N N H IC50 = 3.0 nM 523.38 NC[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL2177378 OBDepict OH HN CH 3 CH 3 H N O N Cl N N H H 3 C H OH IC50 = 3.0 nM 488.03 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC(C)(C)CO)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177367 OBDepict H 3 C O H H NH H N O N Cl N N H CH 3 H HO IC50 = 4.0 nM 528.1 CO[C@H]1CC[C@H](NC[C@@H](C(=O)N2CCN(c3ncnc4c3[C@H](C)C[C@H]4O)CC2)c2ccc(Cl)cc2)CC1 Homo sapiens CHEMBL2188027 assay format
CHEMBL2325993 OBDepict CH 3 N CH 3 N H O NH 2 Cl N N N N H IC50 = 4.0 nM 470.02 CN(C)CCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2177368 OBDepict Cl H N O NH N N O N H CH 3 H HO IC50 = 4.0 nM 514.07 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC4CCOCC4)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL379507 OBDepict NH 2 N H O Cl S Cl N N N H CH 3 IC50 = 4.8 nM 436.37 CNc1nccc(-c2ccc(C(=O)NC(CN)Cc3ccc(Cl)cc3Cl)s2)n1 Homo sapiens CHEMBL868042 single protein format
CHEMBL2177374 OBDepict Cl H N O NH N N N H H 3 C H OH IC50 = 5.0 nM 470.02 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC4CC4)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177366 OBDepict Cl H N O NH N O N N H CH 3 H HO IC50 = 5.0 nM 500.04 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC4CCOCC4)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177385 OBDepict H 3 C NH CH 3 H N O N Cl N N H CH 3 IC50 = 5.0 nM 442.01 CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)CC3)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177379 OBDepict Cl H H HN N O N N N H H 3 C H OH IC50 = 5.0 nM 455.99 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCN4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177388 OBDepict F H N N N N O H HN CH 3 CH 3 Cl IC50 = 5.0 nM 460.0 CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](CF)CC3)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL594755 OBDepict H 2 N N O N H 3 C O H 2 N H N N H 3 C N H IC50 = 6.0 nM 455.52 Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2ccccc2)cc1-c1cnc2[nH]nc(C)c2n1 Homo sapiens CHEMBL1072612 single protein format
CHEMBL2325729 OBDepict Cl N H H O N H 2 N N N N N H IC50 = 6.0 nM 496.06 NC1(C(=O)N[C@@H](CCN2CCCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2177372 OBDepict H 3 C NH CH 3 H N O F N Cl N N H CH 3 H HO IC50 = 7.0 nM 476.0 CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)c(F)c1 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177364 OBDepict Cl H N O NH N N N H CH 3 H HO IC50 = 7.0 nM 498.07 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC4CCCCC4)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2325992 OBDepict CH 3 N H 3 C N H O H 2 N Cl N N N N H IC50 = 7.0 nM 455.99 CN(C)CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2177390 OBDepict H 3 C NH CH 3 H N O N Cl N N H CH 3 H HO IC50 = 8.0 nM 458.01 CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL2325741 OBDepict HO N H H O NH 2 Cl N N N N H IC50 = 8.0 nM 428.92 NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL494089 OBDepict CH 3 N N N O O H 2 N N N H HN OH H 3 C H 3 C IC50 = 9.0 nM 425.49 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 Homo sapiens CHEMBL1028094 single protein format
CHEMBL4574111 OBDepict NH 2 N N N NH 2 N NH 2 ClH IC50 = 9.0 nM 484.01 Cl.Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 Homo sapiens CHEMBL4478655 cell-based format
CHEMBL521642 OBDepict CH 3 N N N O O H 2 N N N H HN OH H 3 C H 3 C IC50 = 9.0 nM 425.49 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@@H]3CCCNC3)c21 Homo sapiens CHEMBL1111480 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 10.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL869530 single protein format
CHEMBL2177363 OBDepict F N H N O N Cl N N H H 3 C H OH IC50 = 10.0 nM 502.03 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CN4CCC(F)CC4)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2325996 OBDepict Cl N H O NH 2 N N N N N H IC50 = 10.0 nM 510.09 NC1(C(=O)NC(CCCN2CCCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL596290 OBDepict H N H 2 N H O N N N O N CH 3 N H IC50 = 10.0 nM 465.52 Cc1n[nH]c2ncc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12 Homo sapiens CHEMBL1069943 single protein format
CHEMBL594523 OBDepict CH 3 N O O N H 2 N H N N CH 3 N N H H IC50 = 10.0 nM 479.54 Cc1nc(-c2ccoc2)c(-c2cnc3[nH]nc(C)c3n2)cc1OC[C@@H](N)Cc1c[nH]c2ccccc12 Homo sapiens CHEMBL1072612 single protein format
CHEMBL2177381 OBDepict H 3 C NH CH 3 H N O N Cl N N H CH 3 H F IC50 = 10.0 nM 460.0 CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3F)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL384964 OBDepict CH 3 HN N N S N H O H N H 3 C CH 3 Cl Cl IC50 = 11.0 nM 464.42 CNc1nccc(-c2ccc(C(=O)N[C@@H](Cc3ccc(Cl)cc3Cl)CN(C)C)s2)n1 Homo sapiens CHEMBL868042 single protein format
CHEMBL2177369 OBDepict Cl H H N H N O N N N H H 3 C H OH IC50 = 12.0 nM 470.02 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCCN4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL1171647 OBDepict H 3 C N H N N N H 2 N N H O F F IC50 = 12.0 nM 400.43 CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12 Homo sapiens CHEMBL1176583 single protein format
CHEMBL2177362 OBDepict O N H N H N F Cl N O N H H 3 C H OH IC50 = 12.0 nM 518.03 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC4CCOCC4)c4ccc(Cl)c(F)c4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL494089 OBDepict CH 3 N N N O O H 2 N N N H HN OH H 3 C H 3 C Ki = 13.0 nM 425.49 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 Homo sapiens CHEMBL1029768 single protein format
CHEMBL2177377 OBDepict CH 3 O NH H N O N Cl N N H CH 3 H HO IC50 = 13.0 nM 474.01 COCCNC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL2325982 OBDepict CH 3 N H O NH 2 Cl N N N N H IC50 = 15.0 nM 412.93 CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL603197 OBDepict H N H 2 N H O N N N O N CH 3 N H IC50 = 15.0 nM 465.52 Cc1n[nH]c2cnc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12 Homo sapiens CHEMBL1069943 single protein format
CHEMBL2325738 OBDepict OH N H O NH 2 Cl N N N N H IC50 = 15.0 nM 428.92 NC1(C(=O)NC(CCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2325995 OBDepict Cl N H O NH 2 N N O N N N H IC50 = 15.0 nM 512.06 NC1(C(=O)NC(CCCN2CCOCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2325743 OBDepict Cl N H CH 3 H O NH 2 N N N N H IC50 = 16.0 nM 398.9 C[C@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL4523032 OBDepict NH 2 N N N N NH 2 ClH IC50 = 16.0 nM 468.99 Cl.Nc1ncccc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 Homo sapiens CHEMBL4478655 cell-based format
CHEMBL494060 OBDepict CH 3 O N H O N N N CH 3 N O H 2 N N HO H 3 C CH 3 IC50 = 16.0 nM 519.61 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCNCCc3ccc(OC)cc3)c21 Homo sapiens CHEMBL1028094 single protein format
CHEMBL1096634 OBDepict H 3 C N N N O NH 2 N O N NH 2 H OH H 3 C H 3 C IC50 = 17.0 nM 447.5 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@H](N)c3ccccc3)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL2325728 OBDepict Cl HN H O N H 2 N N N N N H IC50 = 18.0 nM 482.03 NC1(C(=O)N[C@@H](CCN2CCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL606467 OBDepict N N O O N H 2 N H N N H 3 C N N H H IC50 = 19.0 nM 490.53 Cc1n[nH]c2ncc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c(C#N)nc3-c3ccoc3)nc12 Homo sapiens CHEMBL1072612 single protein format
CHEMBL512135 OBDepict H 2 N N H O S Br N N H IC50 = 20.0 nM 441.35 NCC(NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1)c1ccccc1 Homo sapiens CHEMBL959246 single protein format
CHEMBL2177375 OBDepict F N H H N O N Cl N N H H 3 C H OH IC50 = 21.0 nM 461.97 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCCF)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL1096290 OBDepict CH 3 N N N O H 2 N N N N HO CH 3 CH 3 IC50 = 22.0 nM 395.47 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CN3CCCC3)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL4519558 OBDepict CH 3 HN O N N N NH 2 N NH 2 ClH IC50 = 22.0 nM 526.04 CC(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1.Cl Homo sapiens CHEMBL4478655 cell-based format
CHEMBL2325739 OBDepict OH N H O NH 2 Cl N N N N H IC50 = 22.0 nM 442.95 NC1(C(=O)NC(CCCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2177382 OBDepict H 3 C NH CH 3 H N O N Cl N N H CH 3 H F IC50 = 23.0 nM 460.0 CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@@H]3F)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL2325983 OBDepict Cl HN O H 2 N N N N N H IC50 = 24.0 nM 424.94 NC1(C(=O)NC(c2ccc(Cl)cc2)C2CC2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2177370 OBDepict Cl H H N H N O O N N N H H 3 C H OH IC50 = 26.0 nM 471.99 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4COCCN4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL2177371 OBDepict H 2 N H N O N F F F N N H H 3 C H OH IC50 = 27.0 nM 449.48 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CN)c4ccc(C(F)(F)F)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL385143 OBDepict NH 2 N H H O Cl S Cl N N N H H 3 C IC50 = 27.0 nM 450.4 CNc1nccc(-c2ccc(C(=O)N[C@H](CCN)Cc3ccc(Cl)cc3Cl)s2)n1 Homo sapiens CHEMBL868042 single protein format
CHEMBL2177365 OBDepict H 3 C N H 3 C CH 3 H N O N Cl N N H CH 3 H HO IC50 = 28.0 nM 472.03 CC(C)N(C)C[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2188027 assay format
CHEMBL4556790 OBDepict O N H F H NH H N CH 3 N F F ClH IC50 = 28.0 nM 450.89 Cl.Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c(F)c1 Homo sapiens CHEMBL4830035 single protein format
CHEMBL2325736 OBDepict Cl N H O N H NH 2 S O O CH 3 N N N N H IC50 = 30.0 nM 506.03 CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL2325997 OBDepict Cl N H CH 3 O NH 2 N N N N H IC50 = 30.0 nM 398.9 CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL1097974 OBDepict H 2 N N N N CH 3 OH H 3 C H 3 C N O H 2 N N IC50 = 30.0 nM 369.43 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CCCN)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL383264 OBDepict H N NH 2 H O N N IC50 = 35.0 nM 394.48 N[C@H](COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 Homo sapiens CHEMBL862615 single protein format
CHEMBL2325994 OBDepict Cl N H O NH 2 N N N N N H IC50 = 36.0 nM 496.06 NC1(C(=O)NC(CCCN2CCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL207544 OBDepict CH N O H 2 N H N N H IC50 = 39.0 nM 418.5 C#Cc1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2cnccc2c1 Homo sapiens CHEMBL861322 single protein format
CHEMBL1794065 OBDepict OH O F F F H 3 C N N N O O H 2 N N N OH H 3 C H 3 C NH IC50 = 40.0 nM 539.52 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCC3CCNCC3)c21.O=C(O)C(F)(F)F Homo sapiens CHEMBL1028094 single protein format
CHEMBL2325737 OBDepict OH N H O NH 2 Cl N N N N H IC50 = 40.0 nM 414.9 NC1(C(=O)NC(CO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format
CHEMBL513728 OBDepict NH 2 N H H O S Br N N H IC50 = 40.0 nM 455.38 NC[C@@H](Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 Homo sapiens CHEMBL959246 single protein format
CHEMBL1096291 OBDepict H 2 N O N N N CH 3 OH H 3 C H 3 C N O H 2 N N IC50 = 43.0 nM 371.4 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OCCN)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL4745768 OBDepict Cl N O NH N N N S IC50 = 45.0 nM 524.13 O=C(C(CNC1CCCCC1)c1ccc(Cl)cc1)N1CCN(c2ncnc3sc4c(c23)CCC4)CC1 Homo sapiens CHEMBL4685029 single protein format
CHEMBL2177373 OBDepict NH 2 H N O N Cl N N H CH 3 H HO IC50 = 45.0 nM 415.93 C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CN)c4ccc(Cl)cc4)CC3)c21 Homo sapiens CHEMBL2188027 assay format
CHEMBL1096626 OBDepict H 3 C N N N O NH 2 N O N NH 2 H OH H 3 C H 3 C IC50 = 49.0 nM 447.5 CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@@H](N)c3ccccc3)cc21 Homo sapiens CHEMBL1109954 single protein format
CHEMBL3544960 OBDepict H 2 N OH Cl N N H IC50 = 50.0 nM 313.79 NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(-c2cn[nH]c2)cc1 Homo sapiens CHEMBL4022197 assay format
CHEMBL379300 OBDepict H N H 2 N H O N N CH 3 N H IC50 = 51.0 nM 397.48 Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12 Homo sapiens CHEMBL1252175 cell-based format
CHEMBL598194 OBDepict Cl N H O H 2 N N N N N H IC50 = 57.0 nM 384.87 NC1(C(=O)NCc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL2330884 single protein format