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Q9Y572 | RIPK3_HUMAN | Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -120800.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804483 cell-based format
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -33400.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804483 cell-based format
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -25900.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804483 cell-based format
CHEMBL4439913 OBDepict H 3 C NH O N N O O H 3 C H 3 C CH 3 IC50 = 0.3 nM 365.43 CNC(=O)c1ccc2c(c1)ncn2-c1ccc(CC(=O)OC(C)(C)C)cc1 Homo sapiens CHEMBL4425337 assay format
CHEMBL4470115 OBDepict F N O N H O F O N NH 2 N NH 2 IC50 = 0.3 nM 550.53 Nc1ccc(C#Cc2c(Oc3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)ccnc2N)nc1 Homo sapiens CHEMBL4344880 cell-based format
CHEMBL1171837 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 1.6 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4378731 cell-based format
CHEMBL4455682 OBDepict O N H N O F NH O O N F IC50 = 2.9 nM 502.48 O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4344883 single protein format
CHEMBL4476485 OBDepict O N H N O CH 3 HN O O N F IC50 = 8.0 nM 498.51 Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 Homo sapiens CHEMBL4344883 single protein format
CHEMBL4552106 OBDepict H 3 C O NH 2 N F HN O O N F IC50 = 16.0 nM 472.45 CC#Cc1c(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccnc1N Homo sapiens CHEMBL4344883 single protein format
CHEMBL3823499 OBDepict F N N H N H N S O O H 3 C CH 3 H 3 C IC50 = 16.0 nM 398.46 CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 Homo sapiens CHEMBL3825649 single protein format
CHEMBL4438939 OBDepict F N O N H O O N IC50 = 50.0 nM 451.46 O=C(Nc1ccc(Oc2ccncc2)c2ccccc12)c1cccn(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4344883 single protein format
CHEMBL4476076 OBDepict O N H N O CH 3 CH 3 HN O O N F IC50 = 88.0 nM 512.54 Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc(C)c1Oc1ccnc(NC(=O)C2CC2)c1 Homo sapiens CHEMBL4344883 single protein format
CHEMBL4551490 OBDepict O N H N O CH 3 CH 3 HN O O N F IC50 = 91.0 nM 512.54 Cc1c(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc(Oc2ccnc(NC(=O)C3CC3)c2)c1C Homo sapiens CHEMBL4344883 single protein format
CHEMBL509101 OBDepict F N O NH O F O N N H IC50 = 180.0 nM 458.42 O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4344883 single protein format
CHEMBL4434881 OBDepict F N O N H O H 3 C CH 3 O N IC50 = 180.0 nM 429.45 Cc1c(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc(Oc2ccncc2)c1C Homo sapiens CHEMBL4344883 single protein format
CHEMBL4569395 OBDepict H 3 C O O H H 3 C O H CH 3 H 3 C H HO H H H 3 C O IC50 = 200.0 nM 376.49 CC(=O)O[C@@H]1CCC(C)(C)[C@H]2C[C@@H](O)C3=C[C@@H](CCC(=O)[C@]12C)[C@H](C)C3=O Homo sapiens CHEMBL4378760 cell-based format
CHEMBL2028663 OBDepict H 2 N N N S N H 3 C H 3 C CH 3 F N H S O O F F IC50 = 250.0 nM 519.57 CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 Homo sapiens CHEMBL4378747 cell-based format
CHEMBL3735817 OBDepict CH 3 N N N N N N S IC50 = 270.0 nM 452.59 CN1CCN(c2ccc3nc(-c4cccc(-c5cccs5)c4)c(-c4ccncc4)n3n2)CC1 Homo sapiens CHEMBL3736773 cell-based format
CHEMBL4434926 OBDepict O HN O N N H CH 3 O HN IC50 = 270.0 nM 376.42 Cc1ccc(COC(=O)Nc2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 Homo sapiens CHEMBL4344880 cell-based format
CHEMBL3735315 OBDepict CH 3 N N N N N N S IC50 = 300.0 nM 452.59 CN1CCN(c2ccc3nc(-c4cccc(-c5ccsc5)c4)c(-c4ccncc4)n3n2)CC1 Homo sapiens CHEMBL3736773 cell-based format
CHEMBL4542026 OBDepict F N O N H O CH 3 CH 3 O N IC50 = 320.0 nM 429.45 Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc(C)c1Oc1ccncc1 Homo sapiens CHEMBL4344883 single protein format
CHEMBL4572309 OBDepict F N O N H O F O N IC50 = 400.0 nM 419.39 O=C(Nc1ccc(Oc2ccncc2)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4344883 single protein format
CHEMBL3736408 OBDepict CH 3 N N N N N N IC50 = 450.0 nM 446.56 CN1CCN(c2ccc3nc(-c4cccc(-c5ccccc5)c4)c(-c4ccncc4)n3n2)CC1 Homo sapiens CHEMBL3736773 cell-based format
CHEMBL3735482 OBDepict CH 3 N N N N N N IC50 = 880.0 nM 420.52 CN1CCN(c2ccc3nc(-c4cccc5ccccc45)c(-c4ccncc4)n3n2)CC1 Homo sapiens CHEMBL3736773 cell-based format